Transient lupus anticoagulant associated with hypoprothrombinemia and Factor XII deficiency following adenovirus infection

1993 ◽  
Vol 67 (2) ◽  
pp. 95-99 ◽  
Author(s):  
U. Jaeger ◽  
S. Kapiotis ◽  
I. Pabinger ◽  
E. Puchhammer ◽  
P. A. Kyrle ◽  
...  
Keyword(s):  
Lupus Anticoagulant ◽  
Factor Xii ◽  
Adenovirus Infection ◽  
Factor Xii Deficiency

The Discrimination of Factor XII Deficiency and Lupus Anticoagulant

1996 ◽  
Vol 75 (04) ◽  
pp. 698-699 ◽  
Author(s):  
Walter-Michael Halbmayer ◽  
Alexander Haushofer ◽  
Veronika Angerer ◽  
Michael Fischer
Keyword(s):  
Lupus Anticoagulant ◽  
Factor Xii ◽  
Factor Xii Deficiency

Factor XII Determinations in the Presence and Absence of Phospholipid Antibodies

1998 ◽  
Vol 79 (01) ◽  
pp. 87-90 ◽  
Author(s):  
D. W. Jones ◽  
M. Winter ◽  
M. J. Gallimore
Keyword(s):  
Lower Limit ◽  
Lupus Anticoagulant ◽  
Factor Xii ◽  
Chromogenic Substrate ◽  
Plasma Samples ◽  
Presence And Absence ◽  
Lower Limit Of Normal

SummaryFactor XII (FXII) levels were determined in plasma samples from 29 normal donors, 10 patients with inherited FXII deficiency (all lupus anticoagulant [LA] negative) and 67 LA positive patients, using clotting (FXIIct), chromogenic substrate (FXIIcs) and immunochemical (FXIIag) assays. Excellent correlations were obtained in the three FXII assays with the LA negative samples and between the FXIIcs and FXIIag assays in the LA positive samples. Correlations between both the FXIIcs and FXIIag with FXIIct in the LA positive patients were poor. Of 67 LA positive samples studied, 25 (37.3%) showed lower values in the FXIIct assay; 13 (19.4%) of these patients were pseudo FXII deficient with values of FXII below the lower limit of normal.These results indicate that a diagnosis of FXII deficiency can be made inappropriately in the presence of phospholipid antibodies and that such a diagnosis should not be made by FXIIct assay alone.

Synchronized Inhibition of the Phospholipid Mediated Autoactivation of Factor XII in Plasma by β2-glycoprotein I and Anti-β2-glycoprotein I

1995 ◽  
Vol 73 (05) ◽  
pp. 798-804 ◽  
Author(s):  
Inger Schousboe ◽  
Margit Søe Rasmussen
Keyword(s):  
Lupus Erythematosus ◽  
Lupus Anticoagulant ◽  
Response Curve ◽  
Inhibitory Effect ◽  
Factor Xii ◽  
High Antibody ◽  
Contact Activation ◽  
Maximal Inhibition ◽  
Lupus Anticoagulants ◽  
Glycoprotein I

SummaryLupus anticoagulants are a group of antibodies commonly found in patients with autoimmune diseases such as systemic lupus erythematosus. Lupus anticoagulants inhibit phospholipid dependent coagulation and may bind to negatively charged phospholipids. Recent studies have suggested an association between anti-β2-glycoprotein I and a lupus anticoagulant, whose activity is frequently dependent on the presence of β2-glycoprotein I. Based on these observations, the effect of anti-β2-glycoprotein I on the autoactivation of factor XII in plasma was investigated. Autoactivation initiated by the presence of negatively charged phospholipids, but not by sulfatide, was strongly inhibited by immunoaffinity purified anti-β2-glycoprotein I. The dose-response curve of anti-β2-gly coprotein I was identical with that of a precipitating antibody, showing no inhibition at low and high antibody dilutions and maximal inhibition at an intermediate dilution. At high antibody concentrations, an increased rate of factor Xlla activation was observed. This increase was of the same magnitude as the decreased rate observed in plasma supplemented with the same amount of β2-glycoprotein I as in the plasma itself. This confirms the inhibitory effect of β2-GP-I on the contact activation and shows that inhibition is effective on the autoactivation of factor XII in plasma. The inhibitory action of β2-glycoprotein I was independent of the inhibition caused by the anti- β2-glycoprotein I/β2-glycoprotein I complex suggesting a synchronized inhibition of factor XII autoactivation by β2-glycoprotein I and anti-β2-gly coprotein I. The inhibition caused by the antibody is suggested to be caused by a reduced availability of negatively charged phospholipids due to the binding of the anti-β2- GP-I/β2-GP-I complex. This complex may be a lupus anticoagulant.

A Case of Bladder Tamponade with Factor XII Deficiency in a Cat

2014 ◽  
Vol 45 (1) ◽  
pp. 13-18
Author(s):  
Harumichi ITOH ◽  
Tomoya HARAGUCHI ◽  
Kazuhito ITAMOTO ◽  
Kinya TAMURA ◽  
Satoshi KANBAYASHI ◽  
...  
Keyword(s):  
Factor Xii ◽  
Factor Xii Deficiency

A rare case of not-so-benign factor XII deficiency

2019 ◽  
pp. 1-4
Author(s):  
Adeel Arshad ◽  
Nazia Mohamed ◽  
Absia Jabbar ◽  
Makiko Ban-hoefen
Keyword(s):  
Rare Case ◽  
Factor Xii ◽  
Factor Xii Deficiency

Relationship between Factor XII deficiency and thrombosis: the debate is still open?

2009 ◽  
Vol 27 (4) ◽  
pp. 456-457 ◽  
Author(s):  
Gianfranco Lessiani ◽  
Angela Falco ◽  
Elvira Nicolucci ◽  
Giancarlo Rolandi ◽  
Giovanni Davì
Keyword(s):  
Factor Xii ◽  
Factor Xii Deficiency

Huge left atrial thrombus with mitral stenosis in congenital factor XII deficiency

2002 ◽  
Vol 73 (1) ◽  
pp. 286-288 ◽  
Author(s):  
Tomomi Hasegawa ◽  
Masahisa Uematsu ◽  
Takuro Tsukube ◽  
Yukihiro Takemura ◽  
Yutaka Okita
Keyword(s):  
Mitral Stenosis ◽  
Left Atrial ◽  
Factor Xii ◽  
Left Atrial Thrombus ◽  
Atrial Thrombus ◽  
Factor Xii Deficiency ◽  
Congenital Factor

Genetic analysis of a novel missense mutation (Gly542Ser) with factor XII deficiency in a Chinese patient of consanguineous marriage

2018 ◽  
Vol 107 (4) ◽  
pp. 436-441 ◽  
Author(s):  
Anqing Zou ◽  
Mingshan Wang ◽  
Yanhui Jin ◽  
Xiaoli Cheng ◽  
Kankan Su ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Missense Mutation ◽  
Consanguineous Marriage ◽  
Chinese Patient ◽  
Factor Xii ◽  
Factor Xii Deficiency
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