Relationship between Factor XII deficiency and thrombosis: the debate is still open?

2009 ◽  
Vol 27 (4) ◽  
pp. 456-457 ◽  
Author(s):  
Gianfranco Lessiani ◽  
Angela Falco ◽  
Elvira Nicolucci ◽  
Giancarlo Rolandi ◽  
Giovanni Davì
Keyword(s):  
Factor Xii ◽  
Factor Xii Deficiency

A Case of Bladder Tamponade with Factor XII Deficiency in a Cat

2014 ◽  
Vol 45 (1) ◽  
pp. 13-18
Author(s):  
Harumichi ITOH ◽  
Tomoya HARAGUCHI ◽  
Kazuhito ITAMOTO ◽  
Kinya TAMURA ◽  
Satoshi KANBAYASHI ◽  
...  
Keyword(s):  
Factor Xii ◽  
Factor Xii Deficiency

A rare case of not-so-benign factor XII deficiency

2019 ◽  
pp. 1-4
Author(s):  
Adeel Arshad ◽  
Nazia Mohamed ◽  
Absia Jabbar ◽  
Makiko Ban-hoefen
Keyword(s):  
Rare Case ◽  
Factor Xii ◽  
Factor Xii Deficiency

Huge left atrial thrombus with mitral stenosis in congenital factor XII deficiency

2002 ◽  
Vol 73 (1) ◽  
pp. 286-288 ◽  
Author(s):  
Tomomi Hasegawa ◽  
Masahisa Uematsu ◽  
Takuro Tsukube ◽  
Yukihiro Takemura ◽  
Yutaka Okita
Keyword(s):  
Mitral Stenosis ◽  
Left Atrial ◽  
Factor Xii ◽  
Left Atrial Thrombus ◽  
Atrial Thrombus ◽  
Factor Xii Deficiency ◽  
Congenital Factor

Transient lupus anticoagulant associated with hypoprothrombinemia and Factor XII deficiency following adenovirus infection

1993 ◽  
Vol 67 (2) ◽  
pp. 95-99 ◽  
Author(s):  
U. Jaeger ◽  
S. Kapiotis ◽  
I. Pabinger ◽  
E. Puchhammer ◽  
P. A. Kyrle ◽  
...  
Keyword(s):  
Lupus Anticoagulant ◽  
Factor Xii ◽  
Adenovirus Infection ◽  
Factor Xii Deficiency

Genetic analysis of a novel missense mutation (Gly542Ser) with factor XII deficiency in a Chinese patient of consanguineous marriage

2018 ◽  
Vol 107 (4) ◽  
pp. 436-441 ◽  
Author(s):  
Anqing Zou ◽  
Mingshan Wang ◽  
Yanhui Jin ◽  
Xiaoli Cheng ◽  
Kankan Su ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Missense Mutation ◽  
Consanguineous Marriage ◽  
Chinese Patient ◽  
Factor Xii ◽  
Factor Xii Deficiency

scholarly journals Donor-to-recipient transmission of factor XII deficiency by orthotopic liver transplantation

2019 ◽  
Vol 32 (4) ◽  
pp. 596-598
Author(s):  
Hussien Elsiesy ◽  
Mohamed Shawakat ◽  
Waleed Alhamoudi ◽  
Mohamed Alsebayel ◽  
John Renz ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Factor Xii ◽  
Factor Xii Deficiency

A family with factor XII deficiency: a family study suggesting that factor XII levels are determined by the presence of 3 codominant alleles with variable penetrance

1981 ◽  
Author(s):  
D Roberts ◽  
O Hayne ◽  
E Fraser
Keyword(s):  
General Population ◽  
Family Study ◽  
Controlling Factor ◽  
Factor Xii ◽  
Factor Xii Deficiency ◽  
The Family ◽  
Variable Penetrance

We studied 15 members, in 3 generations of a family in whom the propositus had complete factor XII deficiency. The parents had factor XII levels of 59% and 62%. Three of the siblings had factor XII levels of less than 1%. Three more had factor XII levels of (30±5%). In 3 the levels ranged from (60-87%) and the remaining 2 siblings had levels exceeding 100%. The propositus with a level of less than 1% gave rise to an offspring with a level of 48%.We propose that the gene controlling factor XII production consists of 3 separate alleles expressed codominantly: A - normal, B - low, O - absent. Members of the family with 100% factor XII activity have genotype AA; those with less than 1% activity have genotype OO; subjects with levels of 30% have genotype BO, and those with levels of 60% have genotype AO. We feel our study sheds new light on the inheritance of factor XII and the wide variation of levels in the general population.

scholarly journals Factor XII-Deficient Chicken Plasma as a Useful Target for Screening of Pro- and Anticoagulant Animal Venom Toxins

Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 79
Author(s):  
Benedito C. Prezoto ◽  
Nancy Oguiura
Keyword(s):  
High Sensitivity ◽  
Factor Xii ◽  
Dependent Manner ◽  
Clotting Time ◽  
Natural Factor ◽  
Rotational Thromboelastometry ◽  
Factor Xii Deficiency ◽  
Dose Dependent ◽  
Recalcification Time ◽  
Coagulation Pathway

The sensitivity of vertebrate citrated plasma to pro- and anticoagulant venom or toxins occurs on a microscale level (micrograms). Although it improves responses to agonists, recalcification triggers a relatively fast thrombin formation process in mammalian plasma. As it has a natural factor XII deficiency, the recalcification time (RT) of chicken plasma (CP) is comparatively long [≥ 1800 seconds (s)]. Our objective was to compare the ability of bee venom phospholipase A2 (bvPLA2) to neutralize clot formation induced by an activator of coagulation (the aPTT clot) in recalcified human and chicken plasmas, through rotational thromboelastometry. The strategy used in this study was to find doses of bvPLA2 that were sufficient enough to prolong the clotting time (CT) of these activated plasmas to values within their normal RT range. The CT of CP was prolonged in a dose-dependent manner by bvPLA2, with 17 ± 2.8 ng (n = 6) being sufficient to displace the CT values of the activated samples to ≥ 1800 s. Only amounts up to 380 ± 41 ng (n = 6) of bvPLA2 induced the same effect in activated human plasma samples. In conclusion, the high sensitivity of CP to agonists and rotational thromboelastometry could be useful. For example, during screening procedures for assaying the effects of toxins in several stages of the coagulation pathway, such as clot initiation, formation, stability, strength, or dissolution.

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