Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and urea. XV. Synthesis and biological activity of newortho-substituted benzhydrylureas: Potential synthones of quinazolines and benzodiazepines

1994 ◽  
Vol 28 (7) ◽  
pp. 452-454
Author(s):  
A. A. Bakibaev ◽  
V. K. Gorshkova ◽  
L. G. Tignibidina ◽  
V. V. Shtrykova ◽  
V. D. Filimonov ◽  
...  
Keyword(s):  
Biological Activity ◽  
Monooxygenase System ◽  
Liver Monooxygenase

Synthetic anticonvulsants, antihypoxic agents, and inducers of the liver monooxygenase system. XII. The enzyme-inducing activity of N-aralkyl-N′-acylureas

1994 ◽  
Vol 28 (3) ◽  
pp. 170-172
Author(s):  
A. A. Bakibaev ◽  
R. R. Akhmedzhanov ◽  
L. G. Tignibidina ◽  
T. P. Novozheeva ◽  
V. V. Shtrykova ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase

Synthetic anticonvulsants, antihypoxics, and liver monooxygenase system inducers based on amides and urea. V. Synthesis and anticonvulsive and antihypoxic activities of 1,3 dibenzhydrylureas

1993 ◽  
Vol 27 (4) ◽  
pp. 257-260
Author(s):  
A. A. Bakibaev ◽  
V. K. Gorshkova ◽  
V. V. Shtrykova ◽  
A. S. Saratikov ◽  
V. D. Filimonov ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase

Synthetic anticonvulsants, antihypoxic agents, and inducers of the liver monooxygenase system. XIX. The synthesis, anticonvulsive, and antihypoxic properties of benzhydrylamine carboxylates

1994 ◽  
Vol 28 (3) ◽  
pp. 163-167
Author(s):  
L. G. Tignibidina ◽  
A. A. Bakibaev ◽  
V. K. Gorshkova ◽  
A. S. Saratikov ◽  
M. P. Krauin'sh
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase

scholarly journals SUPRESSION OF MICROSOMAL OXIDATION WEAKENS HISTOCHROME’S DIURETIC EFFECT AT RATS

2013 ◽  
Vol 12 (3) ◽  
pp. 69-75 ◽  
Author(s):  
O. S. Talalaeva ◽  
A. Yu. Zharikov ◽  
Ya. F. Zverev ◽  
S. A. Fedoreyev ◽  
V. M. Bryukhanov ◽  
...  
Keyword(s):  
Initial Level ◽  
Medicinal Form ◽  
Medical Product ◽  
Control Group ◽  
Potassium Ions ◽  
Monooxygenase System ◽  
Diuretic Effect ◽  
Water Excretion ◽  
Daily Urine ◽  
Liver Monooxygenase

Histochrome is the medicinal form of echinochrome (2, 3, 5, 6, 8-pentahydroxy-7-ethyl-1,4-naphthoquinone). Arisen during clinical application of the drug questions concerning its biotransformation have predetermined the aim of this research: to study participation liver monooxygenase system in maintenance of histochrome’s pharmacological activity.Simple and informative method of the lifetime control of liver monooxygenase systems influence on a metabolism of a medical product is the estimation of changes of pharmacological effect of a r esearched preparation on a background microsomal oxidations i nhibitor. In experiments on rats chloramphenicol action on diuretic effect of histochrome, as the most convenient for screening, was i nvestigated.To control group of animals during 10 days were hypodermically entered by histochrome in a doze of 10 mg/kg (n = 15). Experimental animals preliminary oral received 50 mg/kg of chloramphenicol before three hours of histochrome introduction (n = 16). In both groups of animals measured volume daily excretion of water, creathinin, sodium and potassium ions excretions in experimental rats each two days. The initial level of parameters of excretory kidneys functions were estimated before introduction of preparations at animals.Long-term histochrome’s injection was followed by a fivefold increasing of water excretion and simultaneously creathinin growth one. Allocation of ions of sodium was statistically significantly increased by 11-th day of experiment, and potassium ions – since the ninth day of histochrome injection. In conditions preliminary chloramphenicol applications volume daily daily urine output and creathinin excretion were essentially less control parameters. Allocation with urine of ions of sodium was decreased almost twice in comparison with the values, fixed at introduction histochrome. Excretion potassium ions ware corresponded to an initial level during all period of supervision.Taking into account, that chloramphenicol is powerful inhibitor of microsomal oxidations in a liver, it was logical to assume, that excretion functions decrease of kidneys was connected to oppression of the echinochrome metabolism, and the diuretic effect of a preparation was caused not so much primary substance, how many of its metabolism products. Most likely, echinochrome metabolite raises speed glomerular filtrations, providing diuretic reaction of a preparation.

Activity of liver monooxygenase system in rats with low and high resistance to hypoxia

1996 ◽  
Vol 122 (3) ◽  
pp. 906-908
Author(s):  
V. I. Sharapov ◽  
O. R. Grek
Keyword(s):  
High Resistance ◽  
Monooxygenase System ◽  
Resistance To Hypoxia ◽  
Liver Monooxygenase

Reconstitution of liver monooxygenase system in solution from cytochrome P-450 and NADPH-specific flavoprotein monomers

1986 ◽  
Vol 139 (3) ◽  
pp. 883-888 ◽  
Author(s):  
G.I. Bachmanova ◽  
E.D. Skotselyas ◽  
I.P. Kanaeva ◽  
G.P. Kuznetsova ◽  
S.A. Gordeev ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase ◽  
Cytochrome P 450

Combined effect of fascioliasis and diethylnitrosamine carcinogenesis on the activity of the rat liver monooxygenase system

1992 ◽  
Vol 101 (3) ◽  
pp. 475-479 ◽  
Author(s):  
Nelly T. Tsocheva ◽  
Maria B. Kadiiska ◽  
Olga T. Poljakova-Krusteva ◽  
Luka P. Krustev ◽  
Stanislav S. Yanev ◽  
...  
Keyword(s):  
Rat Liver ◽  
Combined Effect ◽  
Monooxygenase System ◽  
Liver Monooxygenase

Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and ureas. XVII. Synthesis of N-benzhydryl-N′-(heteroyl)ureas and studies of their anticonvulsive activity

1994 ◽  
Vol 28 (8) ◽  
pp. 547-549 ◽  
Author(s):  
L. G. Tignibidina ◽  
A. A. Bakibaev ◽  
V. K. Gorshkova ◽  
A. S. Saratikov ◽  
L. G. Fomintseva
Keyword(s):  
Monooxygenase System ◽  
Anticonvulsive Activity ◽  
Liver Monooxygenase

Synthetic anticonvulsants, antihypoxic agents, and inducers of the liver monooxygenase system. XII. The antihypoxic properties of n-benzhydrylamines

1994 ◽  
Vol 28 (3) ◽  
pp. 168-169
Author(s):  
A. A. Bakibaev ◽  
V. K. Gorshkova ◽  
L. G. Tignibidina ◽  
V. D. Filimonov ◽  
N. B. Oleinik ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase
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