Synthetic anticonvulsants, antioxidants, and inducers of the liver monooxygenase system based on amides and ureas. X. Inducers of the cytochrome-P-450-dependent monoxygenase system of the liver on the basis of dibenzazepinones, mono- and bicyclic imidazolamines and isoindolinones

1993 ◽  
Vol 27 (9) ◽  
pp. 628-630
Author(s):  
T. P. Novozheeva ◽  
R. R. Akhmedzhanov ◽  
A. S. Saratikov ◽  
A. A. Bakibaev ◽  
A. Yu. Yagovkin ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase ◽  
Cytochrome P 450

Reconstitution of liver monooxygenase system in solution from cytochrome P-450 and NADPH-specific flavoprotein monomers

1986 ◽  
Vol 139 (3) ◽  
pp. 883-888 ◽  
Author(s):  
G.I. Bachmanova ◽  
E.D. Skotselyas ◽  
I.P. Kanaeva ◽  
G.P. Kuznetsova ◽  
S.A. Gordeev ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase ◽  
Cytochrome P 450

Amide- and urea-based synthetic anticonvulsants, antihypoxics, and inducers of the hepatic monooxygenase system. VII. Effect of benzhydrylureas on the cytochrome P-450-dependent liver monooxygenase system

1993 ◽  
Vol 27 (6) ◽  
pp. 395-397 ◽  
Author(s):  
A. A. Bakibaev ◽  
R. R. Akhmedzhanov ◽  
T. P. Novozheeva ◽  
V. D. Filimono ◽  
L. G. Tignibidina ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Hepatic Monooxygenase ◽  
Liver Monooxygenase ◽  
Cytochrome P 450

IDentification of a microsomal retinoic acid synthase as a microsomal cytochrome P-450-linked monooxygenase system

1993 ◽  
Vol 25 (12) ◽  
pp. 1775-1784 ◽  
Author(s):  
Tomita Shuhei ◽  
Tsujita Maki ◽  
Matsuo Yoshinori ◽  
Yubisui Toshitsugu ◽  
Ichikawa Yoshiyuki
Keyword(s):  
Retinoic Acid ◽  
Monooxygenase System ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Synthetic anticonvulsants, antihypoxic agents, and inducers of the liver monooxygenase system. XII. The enzyme-inducing activity of N-aralkyl-N′-acylureas

1994 ◽  
Vol 28 (3) ◽  
pp. 170-172
Author(s):  
A. A. Bakibaev ◽  
R. R. Akhmedzhanov ◽  
L. G. Tignibidina ◽  
T. P. Novozheeva ◽  
V. V. Shtrykova ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase

scholarly journals Effects of Bromocriptine on Hepatic Cytochrome P-450 Monooxygenase System

1989 ◽  
Vol 49 (2) ◽  
pp. 285-291
Author(s):  
Shabbir M. MOOCHHALA ◽  
Edmund J.D. LEE ◽  
Gwendolene T.M. HU ◽  
O.S. KOH ◽  
Gordon BECKET
Keyword(s):  
Monooxygenase System ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

scholarly journals Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans.

1997 ◽  
Vol 41 (7) ◽  
pp. 1465-1467 ◽  
Author(s):  
D C Lamb ◽  
B C Baldwin ◽  
K J Kwon-Chung ◽  
S L Kelly
Keyword(s):  
Cryptococcus Neoformans ◽  
Pathogenic Fungus ◽  
Ergosterol Biosynthesis ◽  
Classical Type ◽  
Monooxygenase System ◽  
Inhibition Of Growth ◽  
Fluconazole Therapy ◽  
Specific Localization ◽  
Cytochrome P 450

We investigated the stereoselective inhibition of growth and ergosterol biosynthesis by SCH39304 in the pathogenic fungus Cryptococcus neoformans obtained from four AIDS patients who failed fluconazole therapy and compared the results to those obtained with a wild-type strain. For all strains, the MICs of the RR isomer were approximately half those of the racemate, with the SS enantiomer showing no inhibitory activity. The 50% inhibitory concentrations for in vitro ergosterol biosynthesis correlated with the MIC data, indicating stereoselective inhibition of their target P-450 enzyme, sterol 14alpha-demethylase, as the cause of this difference. The RR enantiomer produced classical type II spectra on addition to microsomal extracts of the strains, whereas the SS enantiomer showed an absence of binding. Stereo- and regio-specific localization of N-1 substituent groups of SCH39304 within the active site of the enzyme determined the unique discrimination between its two enantiomers, and the inability to bind to sterol 14alpha-demethylase is also true of other P-450 enzymes contained in the microsomal fraction. As previously observed for other antifungal azoles, isolates obtained following failure of fluconazole therapy showed resistance to SCH39304 and its RR enantiomer. This resistance could be associated with an alteration in the sensitivity of ergosterol biosynthesis in vitro. These alterations did not cause any changes allowing the SS enantiomer to bind to the P-450 mediating sterol 14alpha-demethylation.

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