The acute treatment of bipolar depression: Historically relevant and recent controlled trials

2006 ◽  
Vol 4 (4) ◽  
pp. 151-158
Author(s):  
Philip D. Kronstein ◽  
Carlos A. Zarate
Keyword(s):  
Acute Treatment ◽  
Bipolar Depression ◽  
Controlled Trials

Double-Blind, Randomized, Placebo-Controlled Trials of Ethyl-Eicosapentanoate in the Treatment of Bipolar Depression and Rapid Cycling Bipolar Disorder

2006 ◽  
Vol 60 (9) ◽  
pp. 1020-1022 ◽  
Author(s):  
Paul E. Keck ◽  
Jim Mintz ◽  
Susan L. McElroy ◽  
Marlene P. Freeman ◽  
Trisha Suppes ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Bipolar Depression ◽  
Controlled Trials ◽  
Rapid Cycling ◽  
Double Blind

scholarly journals Neuromodulation techniques for acute and preventive migraine treatment: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Xavier Moisset ◽  
Bruno Pereira ◽  
Daniel Ciampi de Andrade ◽  
Denys Fontaine ◽  
Michel Lantéri-Minet ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Nerve Stimulation ◽  
Acute Treatment ◽  
Meta Analysis ◽  
Preventive Treatment ◽  
Migraine Treatment ◽  
Controlled Trials ◽  
Electrical Nerve Stimulation ◽  
Randomized Controlled

Abstract Background Several neuromodulation methods exists for migraine treatment. The aim of the present study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) focusing on migraine treatment using neurostimulation methods. Methods We searched Medline and Embase up to July 1, 2020 for RCTs reporting acute or preventive treatment of migraine with either non-invasive or invasive neurostimulation methods. Two researchers independently assessed the eligibility of the retrieved studies and extracted data. Outcomes for the quantitative synthesis were 2 h pain free for acute treatment and headache days per month for preventive treatment. We performed subgroup analyses by treatment (stimulation method and site of application). Estimates were pooled using random-effects meta-analysis. Results Thirty-eight articles were included in the qualitative analysis (7 acute, 31 preventive) and 34 in the quantitative evaluation (6 acute, 28 preventive). Remote electrical neuromodulation (REN) was effective for acute treatment. Data were insufficient to draw conclusions for any other techniques (single studies). Invasive occipital nerve stimulation (ONS) was effective for migraine prevention, with a large effect size but considerable heterogeneity, whereas supra-orbital transcutaneous electrical nerve stimulation (TENS), percutaneous electrical nerve stimulation (PENS), and high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) were effective, with small to medium effect sizes. Vagus-nerve stimulation, left prefrontal cortex rTMS, and cathodal transcranial direct current stimulation (tDCS) over the M1 had no significant effect and heterogeneity was high. Conclusion Several neuromodulation methods are of potential interest for migraine management, but the quality of the evidence is very poor. Future large and well-conducted studies are needed and could improve on the present results.

scholarly journals Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta‐analysis of randomized controlled trials

2020 ◽  
Vol 22 (2) ◽  
pp. 109-120 ◽  
Author(s):  
Nicolas A. Nunez ◽  
Balwinder Singh ◽  
Francisco Romo‐Nava ◽  
Boney Joseph ◽  
Marin Veldic ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Bipolar Depression ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled

Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials

2008 ◽  
Vol 10 (2) ◽  
pp. 323-333 ◽  
Author(s):  
Joseph R Calabrese ◽  
Russell F Huffman ◽  
Robin L White ◽  
Suzanne Edwards ◽  
Thomas R Thompson ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Acute Treatment ◽  
Bipolar Depression ◽  
Controlled Clinical Trials ◽  
Double Blind ◽  
Double Blind Placebo

P.3.07 Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis

2008 ◽  
Vol 18 ◽  
pp. s68-s69
Author(s):  
N. Cruz ◽  
J.M. Goikolea ◽  
J. Sanchez-Moreno ◽  
E. Vieta
Keyword(s):  
Bipolar Depression ◽  
Meta Analysis ◽  
Controlled Trials
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