Pituitary sex steroid receptors: Localization and function

1997 ◽  
Vol 8 (2) ◽  
pp. 91-108 ◽  
Author(s):  
Lucia Stefaneanu
Keyword(s):  
Steroid Receptors ◽  
Sex Steroid ◽  
Sex Steroid Receptors ◽  
And Function

scholarly journals DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors

2012 ◽  
Vol 23 (1) ◽  
pp. 188-199 ◽  
Author(s):  
Ali Pedram ◽  
Mahnaz Razandi ◽  
Robert J. Deschenes ◽  
Ellis R Levin
Keyword(s):  
Membrane Trafficking ◽  
Steroid Receptors ◽  
Protein S ◽  
Steroid Receptor ◽  
Sex Steroid ◽  
Target Cells ◽  
Sex Steroid Receptors ◽  
Receptor Localization ◽  
And Function ◽  
Pat Protein

Classical estrogen, progesterone, and androgen receptors (ERs, PRs, and ARs) localize outside the nucleus at the plasma membrane of target cells. From the membrane, the receptors signal to activate kinase cascades that are essential for the modulation of transcription and nongenomic functions in many target cells. ER, PR, and AR trafficking to the membrane requires receptor palmitoylation by palmitoylacyltransferase (PAT) protein(s). However, the identity of the steroid receptor PAT(s) is unknown. We identified the DHHC-7 and -21 proteins as conserved PATs for the sex steroid receptors. From DHHC-7 and -21 knockdown studies, the PATs are required for endogenous ER, PR, and AR palmitoylation, membrane trafficking, and rapid signal transduction in cancer cells. Thus the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function.

Antagonism by Progesterone of Diethylstilbestrol-lnduced Pituitary Tumorigenesis in Fischer 344 Rats: Effects on Sex Steroid Receptors and Tyrosine Hydroxylase mRNA

1996 ◽  
Vol 63 (6) ◽  
pp. 530-539 ◽  
Author(s):  
Gerardo G. Piroli ◽  
Claudia A. Grillo ◽  
Monica G. Ferrini ◽  
Victoria Lux-Lantos ◽  
Alejandro F. De Nicola
Keyword(s):  
Tyrosine Hydroxylase ◽  
Steroid Receptors ◽  
Sex Steroid ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Sex Steroid Receptors ◽  
Pituitary Tumorigenesis

484 Sex steroid receptors in 53 human CNS neuroepithelial tumors

1983 ◽  
Vol 19 ◽  
pp. 166
Author(s):  
J. Hassoun ◽  
P.M. Martin ◽  
R.P. Vigouroux ◽  
M. Toga ◽  
M. Moguilewsky ◽  
...  
Keyword(s):  
Steroid Receptors ◽  
Sex Steroid ◽  
Neuroepithelial Tumors ◽  
Sex Steroid Receptors

scholarly journals Role of sex steroid receptors in pathobiology of hepatocellular carcinoma

2008 ◽  
Vol 14 (39) ◽  
pp. 5945 ◽  
Author(s):  
Mamta Kalra ◽  
Jary Mayes ◽  
Senait Assefa ◽  
Anil K Kaul ◽  
Rashmi Kaul
Keyword(s):  
Hepatocellular Carcinoma ◽  
Steroid Receptors ◽  
Sex Steroid ◽  
Sex Steroid Receptors
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