Establishment, characterization and drug sensitivity of a new anaplastic thyroid carcinoma cell line (BHT-101)

1993 ◽  
Vol 63 (1) ◽  
pp. 263-269 ◽  
Author(s):  
István Pályi ◽  
Ilona Péter ◽  
Dóra Daubner ◽  
Borbála Vincze ◽  
István Lõrincz
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Drug Sensitivity ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

scholarly journals Therapeutic Usefulness of Wild-Typep53Gene Introduction in ap53-Null Anaplastic Thyroid Carcinoma Cell Line

1998 ◽  
Vol 83 (10) ◽  
pp. 3668-3672 ◽  
Author(s):  
Masaharu Narimatsu ◽  
Yuji Nagayama ◽  
Kozo Akino ◽  
Masako Yasuda ◽  
Toshinori Yamamoto ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

scholarly journals Clodronate alleviates cachexia and prolongs survival in nude mice xenografted with an anaplastic thyroid carcinoma cell line

2006 ◽  
Vol 190 (2) ◽  
pp. 415-423 ◽  
Author(s):  
Cheng-Hsu Wang ◽  
Yung-Chi Shen ◽  
Jia-Juan Hsieh ◽  
Kun-Yun Yeh ◽  
John Wen-Cheng Chang
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Nude Mice ◽  
Cancer Cachexia ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Dependent Manner ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

Cancer cachexia is one of the most common manifestations of advanced malignant disease and is frequently associated with decreased survival. Previously, we reported the establishment of a new anaplastic thyroid carcinoma cell line, Thena, and its mouse xenograft, Thena-Nu, which induced cachexia in athymic nude mice. Subsequent studies showed that the addition of clodronate to Thena-Nu cultures reduced cell proliferation as well as cytokine production in a dose- and time-dependent manner. Weekly administration of clodronate induced tumor cytostasis, attenuation of cachexia, as well as prolongation of survival in Thena-Nu-bearing mice. Reduced serum interleukin 6, tumor necrosis factor-α, and granulocyte colony stimulating factor levels were detected, whereas, serum leukemia inhibitory factor levels were not reduced. Liver necrosis, observed in tumor-bearing mice, was also improved following clodronate treatment. Discontinuation of clodronate treatment, however, resulted in progressive tumor growth and weight loss. Our results demonstrated that clodronate could exert therapeutic efficacy on amelioration of cancer cachexia in the hosts. Nevertheless, this study also points out that a longer period of treatment is required to maintain these effects.

scholarly journals Production of Multiple Growth Factors by a Newly Established Human Thyroid Carcinoma Cell Line

1992 ◽  
Vol 83 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Kaoru Tohyama ◽  
Yataro Yoshida ◽  
Kensaku Ohashi ◽  
Emiko Sano ◽  
Hisataka Kobayashi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Human Thyroid ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

Biosynthesis of an asparagine-linked oligosaccharide-containing calcitonin by a rat medullary thyroid carcinoma cell line

Biochemistry ◽  
1986 ◽  
Vol 25 (10) ◽  
pp. 2995-3000 ◽  
Author(s):  
Kathleen Corey Flanders ◽  
Roger S. Birnbaum ◽  
Walter C. Mahoney ◽  
Bernard A. Roos
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Medullary Thyroid Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Medullary Thyroid ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell
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