scholarly journals Decreased hypothalamic prostaglandin D2 and prostaglandin E2 contents during isoflurane anaesthesia in rats

1995 ◽  
Vol 42 (11) ◽  
pp. 1031-1034 ◽  
Author(s):  
Tetsumi Sato ◽  
Isao Araki ◽  
Tetsuya Kushikata ◽  
Hirobumi Ohkawa ◽  
Hironori Ishihara ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Prostaglandin D2 ◽  
Isoflurane Anaesthesia

Activated human dendritic cells express inducible cyclo‐oxygenase and synthesize prostaglandin E2 but not prostaglandin D2

2004 ◽  
Vol 82 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Mirjana Fogel‐Petrovic ◽  
Julie A Long ◽  
Darryl A Knight ◽  
Philip J Thompson ◽  
John W Upham
Keyword(s):  
Dendritic Cells ◽  
Prostaglandin E2 ◽  
Prostaglandin D2 ◽  
Human Dendritic Cells

scholarly journals Mechanism of prostaglandin biosynthesis in rabbit kidney medulla. A rate-limiting step and the differential stimulatory actions of L-adrenaline and glutathione

1976 ◽  
Vol 160 (3) ◽  
pp. 577-581 ◽  
Author(s):  
H H Tai
Keyword(s):  
Prostaglandin E2 ◽  
Microsomal Fraction ◽  
Reduced Glutathione ◽  
Prostaglandin F2α ◽  
Rabbit Kidney ◽  
Prostaglandin D2 ◽  
Kidney Medulla ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
Rate Limiting

Microsomal prostaglandin synthase (EC 1.14.99.1) from rabbit kidney medulla was assayed with [5,6,8,9,11,12,14,15-3H]-and [1-14C]-arachidonic acid as the substrate. The ratios of prostaglandin F2α to prostaglandin E2 and to prostaglandin D2 were determined by both 3H and 14C labelling. When 3H was used as a label the ratios were much higher than with 14C labelling indicating that the removal of hydrogen at C-9 or C-11 was the rate-limiting step in the biosynthesis of prostaglandin E2 or prostaglandin D2. This finding shows that the octatritiated arachidonic acid is not the appropriate substrate marker for studying the regulation of the synthesis of different prostaglandins by various agents. When the enzyme assay was carried out in the presence of SnCl2, which was capable of accumulating exclusively prostaglandin F2α at the expenses of prostaglandin E2 and prostaglandin D2, the addition of L-adrenaline to the microsomal fraction either alone or with reduced glutathione equally stimulated the formation of prostaglandin F2α, whereas the addition of reduced glutathione to the microsomal fraction either alone or with L-adrenaline produced no additional effect. These results suggest that endoperoxide is formed as the common intermediate for the biosynthesis of three different prostaglandins in rabbit kidney medulla, and that L-adrenaline stimulates the synthesis of endoperoxide, whereas reduced glutathione facilitates the formation of prostaglandins from endoperoxide.

Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice

2005 ◽  
Vol 518 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Yusuke Honma ◽  
Iwao Arai ◽  
Yuki Hashimoto ◽  
Nobuko Futaki ◽  
Masanori Sugimoto ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Prostaglandin D2 ◽  
Barrier Disruption

Prostaglandin D2 sustains the pyrogenic effect of prostaglandin E2

2009 ◽  
Vol 608 (1-3) ◽  
pp. 28-31 ◽  
Author(s):  
Wei Gao ◽  
Achim Schmidtko ◽  
Ruirui Lu ◽  
Christian Brenneis ◽  
Carlo Angioni ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Prostaglandin D2
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