HOW TO CHOOSE A LOCAL ANESTHETIC FOR PERIPHERAL NERVE BLOCK

InPharma ◽  
1980 ◽  
Vol 262 (1) ◽  
pp. 5-5
2009 ◽  
Vol 34 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Urs Eichenberger ◽  
Stefan Stöckli ◽  
Peter Marhofer ◽  
Gudrun Huber ◽  
Patrick Willimann ◽  
...  

Author(s):  
Diego Tavoletti ◽  
Elisabetta Rosanò ◽  
Elisabetta Cerutti ◽  
Luca Pecora

Introduction: Brugada syndrome is a rare arrhythmic disorder associated to ventricular fibrillation and sudden cardiac death. General recommendations in Brugada syndrome patient are focused on avoiding increases in vagal tone and precipitating agents such as electrolyte disorders, hypo/hyperthermia and drugs. Anesthetic management in Brugada syndrome patient has been described in many case reports, however it is still unknown which anesthesia is the safest. Local anesthetic may have a theoretical arrhythmogenic risk, but currently there is no clear evidence and their risk is still debated. Peripheral nerve block avoids autonomic nervous system changes that occur with other anesthetic techniques and it is associated to a lower level in the plasma concentration of the local anesthetic compared with neuraxial anesthesia. Case Report: We report a case of a 38-year-old man patient with Brugada syndrome who underwent urgent orthopedic surgery which was managed with a combined femoral and sciatic nerve blocks using levobupivacaine without any complications. Conclusions: Peripheral nerve block with levobupivacaine provided good analgesia, hemodynamic and cardiac stability in Brugada syndrome patient. Keywords: Brugada syndrome, Anesthesia, Levobupivacaine, Peripheral nerve block, Regional anesthesia


Author(s):  
Iyabo Muse ◽  
Nii Amon Robertson

Peripheral nerve block is an excellent alternative to general anesthesia for optimal anesthesia and analgesia for shoulder arthroscopy. Interscalene brachial plexus block provides good coverage of the shoulder. Peripheral nerve block can be used as a primary anesthetic for various types of orthopedic surgery such as rotator cuff repair, humerus fracture, and total shoulder arthroplasty. Some of the benefits of using this technique include the decrease in pulmonary complications, surgical bleeding, and postoperative nausea and vomiting. However, there are absolute contraindications to performing a nerve block such as patient refusal and infection at the site of injection. There are also complications of local anesthetic injection that may occur, of which local anesthetic toxicity and neuronal injuries are the most detrimental. Even with the potential for complications, peripheral nerve block is still an excellent technique for use in certain cases in the hands of a skilled and well-trained regional anesthesiologist.


PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137312 ◽  
Author(s):  
Meghan A. Kirksey ◽  
Stephen C. Haskins ◽  
Jennifer Cheng ◽  
Spencer S. Liu

1995 ◽  
Vol 83 (3) ◽  
pp. 583-592. ◽  
Author(s):  
F. A. Popitz-Bergez ◽  
S. Leeson ◽  
G. R. Strichartz ◽  
J. G. Thalhammer

Background During peripheral nerve block, local anesthetic (LA) penetrates within and along the nerve to produce the observed functional deficits. Although much is known about the kinetics and steady-state relation for LA inhibition of impulse activity in vitro in isolated nerve, little is known about the relation between functional loss and intraneural LA content in vivo. This study was undertaken to investigate the relation of functional change to intraneural LA. Methods A sciatic nerve block was performed in rats with 0.1 ml 1% lidocaine radiolabeled with 14C. The total intraneural uptake of LA was determined at different times after injection, and the distribution of lidocaine along the nerve was assayed at different stages of functional block. Drug content was also compared with equilibrium lidocaine uptake in the isolated rat sciatic nerve. Results Total intraneural lidocaine in vivo increased to near steady-state in about 3 min, stabilizing at approximately 14.3 nmol/mg wet tissue for about 12 min before decreasing to zero at 70 min after injection. Although intraneural lidocaine was 1.6% of the injected dose during full block, only 0.3% was left when deep pain sensation returned and 0.065% was still detected when functions fully recovered. Despite these large differences in total lidocaine content, the longitudinal distribution remained constant. Intraneural lidocaine concentrations obtained at full block and partial recovery could be achieved in vitro by equilibration in 0.7-0.9 and 0.2-0.3 mM lidocaine, respectively. Conclusions During peripheral nerve block only a small amount of injected LA penetrates into the nerve. The intraneural content of LA correlates with the depth of functional block.


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