Relaxant effect of the calcitonin gene-related peptide (CGRP) on the nonpregnant and pregnant rat uterus. Comparison with vascular tissue

1998 ◽  
Vol 357 (4) ◽  
pp. 446-453 ◽  
Author(s):  
Abdelmajid Anouar ◽  
Alain Schirar ◽  
G. Germain
Keyword(s):  
Vascular Tissue ◽  
Calcitonin Gene Related Peptide ◽  
Rat Uterus ◽  
Pregnant Rat ◽  
Relaxant Effect ◽  
Related Peptide ◽  
Calcitonin Gene

Cyclooxygenase Inhibitors Modify the Relaxant Effect of Vasoactive Intestinal Polypeptide and Substance P in Isolated Porcine Ophthalmic Artery

Cephalalgia ◽  
1992 ◽  
Vol 12 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Maurice B Vincent
Keyword(s):  
Substance P ◽  
Ophthalmic Artery ◽  
Calcitonin Gene Related Peptide ◽  
Cyclooxygenase Inhibitors ◽  
Plasma Extravasation ◽  
Relaxant Effect ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Ophthalmic Arteries

The absolute indomethacin effect in some unilateral headaches may, at least partially, be cyclooxygenase inhibition-independent. Aspirin and indomethacin, for example, may inhibit the neurogenically induced plasma extravasation in rat dura mater. Given the putative involvement of trigeminal neuropeptides in the pathophysiology of these conditions, the influence of cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid (ASA) and naproxen) has been studied upon substance P, calcitonin gene-related peptide and vasoactive intestinal peptide (VIP)-induced vasodilatation in PGF2a precontracted porcine ophthalmic arteries in vitro. None of the cyclooxygenase inhibitors significantly altered the effects of calcitonin gene-related peptide. The 10-10 mol/1 VIP-induced relaxation was inhibited significantly by all three cyclooxygenase inhibitors. Substance P-induced relaxation (from 10-10 to 10-8 mol/l) was enhanced by ASA and inhibited both by naproxen and, to a lesser extent, by indomethacin. The results suggest mainly that VIP-induced relaxations, particularly at lower concentrations, may be inhibited by all three cyclooxygenase inhibitors, and that naproxen, to a greater extent than aspirin or indomethacin, showed a tendency to inhibit vasodilatation induced by all peptides.

scholarly journals Regulation of Calcitonin Gene-Related Peptide Receptors in the Rat Uterus During Pregnancy and Labor and by Progesterone1

1999 ◽  
Vol 61 (4) ◽  
pp. 1023-1030 ◽  
Author(s):  
C. Yallampalli ◽  
P.R.R. Gangula ◽  
S. Kondapaka ◽  
Li Fang ◽  
S. Wimalawansa
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Peptide Receptors ◽  
Rat Uterus ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Mechanisms Involved in Calcitonin Gene-Related Peptide-Induced Relaxation in Pregnant Rat Uterine Artery1

2003 ◽  
Vol 69 (5) ◽  
pp. 1635-1641 ◽  
Author(s):  
P.R.R. Gangula ◽  
C. Thota ◽  
S.J. Wimalawansa ◽  
R.D. Bukoski ◽  
C. Yallampalli
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Pregnant Rat ◽  
Related Peptide ◽  
Calcitonin Gene
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