Chenodeoxycholic and deoxycholic acids induced positive inotropic and negative chronotropic effects on rat heart

2020 ◽  
Author(s):  
Jie Gao ◽  
Guanyin Yuan ◽  
Zhan Xu ◽  
Luyao Lan ◽  
Wenkuan Xin
Keyword(s):  
Rat Heart ◽  
Chronotropic Effects

Bitter taste receptor agonists induced chronotropic effects on rat heart

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Guanyin Yuan ◽  
Yang Jing ◽  
Ting Wang ◽  
Vitor Samuel Leite Fernandes ◽  
Wenkuan Xin
Keyword(s):  
Rat Heart ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Bitter Taste Receptor ◽  
Receptor Agonists ◽  
Chronotropic Effects

The inotropic and chronotropic effects of rheum officinale baillon on rat heart

1990 ◽  
Vol 183 (2) ◽  
pp. 358
Author(s):  
C.-F. Chiang ◽  
K.N. Barnouin ◽  
W.L. Chai ◽  
C.F. Chen
Keyword(s):  
Rat Heart ◽  
Chronotropic Effects

scholarly journals The dose-dependent effect of chronic Verapamil treatment on cardiac function in isolated rat heart with Hypertension

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
S Simovic ◽  
J Jeremic ◽  
G Davidovic ◽  
I Srejovic ◽  
V Zivkovic ◽  
...  
Keyword(s):  
Heart Rate ◽  
Rat Heart ◽  
Coronary Flow ◽  
Chronic Treatment ◽  
Low Dose ◽  
Isolated Rat Heart ◽  
High Dose ◽  
Chronotropic Effects ◽  
Dose Dependent ◽  
Isolated Rat

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Verapamil, a calcium channel blocker, is used for treatment of hypertension, paroxysmal supraventricular tachycardia  and angina pectoris. It primarily blocks L-type calcium channels preventing excessive influx of calcium into cardiomyocytes, leading to negative inotropic effect, and smooth muscle cells resulting in reduced relaxation of vasculature. With calcium antagonism it also causes negative chronotropic effect. However, there is no data on it’s dose-dependent effects on cardiac dynamic parameters and heart rate on isolated rat heart with hypertension. Purpose To investigate chronic, dose-dependent effects of Verapamil on cardiodynamic parameters in isolated rat heart with hypertension. Methods The present 4-week study was carried out on 24 spontaneously hypertensive Wistar Kyoto male rats  (6 weeks old): Control (n = 6), rats treated with 0.5 mg/kg/day of Verapamil (n = 6), rats treated with 5 mg/kg/day of Verapamil (n = 6) and rats treated with 50 mg/kg/day of Verapamil (n = 6). Isolated rat hearts were perfused on Langendorff perfusion apparatus. Results Chronic, low-dose Verapamil treatment significantly depressed function of all cardiodynamic parameters of the hypertensive heart when compared to the rats treated with higher doses of Verapamil (p < 0.001), except on the coronary flow and heart rate when compared to the Control (p= 0.137; p = 1.000, respectively). There was no significant differences between Verapamil in middle dose (5 mg/kg/day) and the Control group in inotropic (p = 0.415) and lusitropic (p = 1.000) effects, while it significantly lowered values of coronary flow (p = 0.002). It achieved significantly lower inotropic, lusitropic and chronotropic effects (p < 0.001) than high Verapamil dose and significantly better inotropic (p = 0.017), lusitropic (p < 0.001), but not chronotropic effects than low-dose Verapamil treatment (p = 0.179). High-dose, chronic treatment with Verapamil significantly intensified function of  the isolated rat heart with hypertension when compared to Control and lower doses of Verapamil (p < 0.001), without significant effects on coronary flow (p = 0.363). Conclusions Chronic treatment with Verapamil in high dose achieved better inotropic, chronotropic and lusitropic effects than treatment in low and middle doses of Verapamil, without significant effects on coronary flow. There is dose-depended effect of chronic Verapamil treatment on cardiac function of isolated rat heart with hypertension.

The inotropic and chronotropic effects of rheum officinale baillon on rat heart

1990 ◽  
Vol 183 (6) ◽  
pp. iii-iv
Author(s):  
C.-F. Chiang ◽  
K.N. Barnouin ◽  
W.L. Chai ◽  
C.F. Chen
Keyword(s):  
Rat Heart ◽  
Chronotropic Effects

The ino- and chronotropic effects of imidazoline drugs on isolated rat heart atria – are I1- imidazoline receptors involved?

2013 ◽  
Vol 65 ◽  
pp. 40-41
Author(s):  
Justyna Długokęcka ◽  
Magdalena Grudzień ◽  
Antoni Nasal ◽  
Aleksandra Radwańska ◽  
Roman Kaliszan
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Imidazoline Receptors ◽  
Chronotropic Effects ◽  
Heart Atria ◽  
Isolated Rat

Microwave-induced chronotropic effects in the isolated rat heart

1977 ◽  
Vol 5 (4) ◽  
pp. 395-409 ◽  
Author(s):  
R. G. Olsen ◽  
J. L. Lords ◽  
C. H. Durney
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Chronotropic Effects ◽  
Isolated Rat

scholarly journals Arachidonic acid-mediated chronotropic effects of CCK-8 on rat heart

1992 ◽  
Vol 58 ◽  
pp. 221
Author(s):  
Yoshinobu Komada ◽  
Mariko Nishiyama ◽  
Osamu Shinmi ◽  
Katsutoshi Goto ◽  
Sadao Kimura
Keyword(s):  
Arachidonic Acid ◽  
Rat Heart ◽  
Chronotropic Effects

Rigorous swim training impairs mitochondrial function in post-ischaemic rat heart

1997 ◽  
Vol 160 (1) ◽  
pp. 139-148
Author(s):  
S.B. LEICHTWEIS ◽  
C. LEEUWENBURGH ◽  
D. J. PARMELEE ◽  
R. FIEBIG ◽  
L. L. JI
Keyword(s):  
Mitochondrial Function ◽  
Rat Heart

459 Myocardial NOS1-derived NO production regulates basal and b-adrenergic cardial contractility in rat heart failure

2003 ◽  
Vol 2 (1) ◽  
pp. 93-94
Author(s):  
J BENDALL ◽  
P RATAJCZAK ◽  
T DAMY ◽  
E ROBIDEL ◽  
F MAROTTE ◽  
...  
Keyword(s):  
Heart Failure ◽  
Rat Heart ◽  
No Production
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