scholarly journals Extended access to amphetamine self-administration increases impulsive choice in a delay discounting task in rats

2009 ◽  
Vol 207 (3) ◽  
pp. 391-400 ◽  
Author(s):  
Cassandra D. Gipson ◽  
Michael T. Bardo
Keyword(s):  
Delay Discounting ◽  
Impulsive Choice ◽  
Self Administration ◽  
Extended Access

scholarly journals Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task.

2014 ◽  
Vol 128 (4) ◽  
pp. 419-429 ◽  
Author(s):  
Marci R. Mitchell ◽  
Virginia G. Weiss ◽  
Dominique J. Ouimet ◽  
Rita A. Fuchs ◽  
Drake Morgan ◽  
...  
Keyword(s):  
Delay Discounting ◽  
Impulsive Choice ◽  
Self Administration

scholarly journals Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akhil Sharma ◽  
Arman Harutyunyan ◽  
Bernard L. Schneider ◽  
Anna Moszczynska
Keyword(s):  
Neural Substrates ◽  
Genetically Engineered ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Self Administration ◽  
Methamphetamine Use ◽  
New Therapeutic Approaches ◽  
Extended Access ◽  
High Doses ◽  
Methamphetamine Use Disorder

AbstractThere is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target for METH use disorder. PARKIN knockout, PARKIN-overexpressing, and wild-type young adult male Long Evans rats were trained to self-administer high doses of METH using an extended-access METH self-administration paradigm. Reinforcing/rewarding properties of METH were assessed by quantifying drug-taking behavior and time spent in a METH-paired environment. PARKIN knockout rats self-administered more METH and spent more time in the METH-paired environment than wild-type rats. Wild-type rats overexpressing PARKIN self-administered less METH and spent less time in the METH-paired environment. PARKIN knockout rats overexpressing PARKIN self-administered less METH during the first half of drug self-administration days than PARKIN-deficient rats. The results indicate that rats with PARKIN excess or PARKIN deficit are useful models for studying neural substrates underlying “resilience” or vulnerability to METH use disorder and identify PARKIN as a novel potential drug target to treat heavy use of METH.

Strain differences in the dose–response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats

2010 ◽  
Vol 25 (6) ◽  
pp. 783-791 ◽  
Author(s):  
Carmen García-Lecumberri ◽  
Isabel Torres ◽  
Sonsoles Martín ◽  
José A Crespo ◽  
Miguel Miguéns ◽  
...  
Keyword(s):  
Dose Response ◽  
Strain Differences ◽  
Impulsive Choice ◽  
Fischer 344 Rats ◽  
Response Relationship ◽  
Self Administration ◽  
Dose Response Relationship ◽  
Fischer 344

scholarly journals Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats

2011 ◽  
Vol 17 (2) ◽  
pp. 300-308 ◽  
Author(s):  
Eric P. Zorrilla ◽  
Sunmee Wee ◽  
Yu Zhao ◽  
Sheila Specio ◽  
Benjamin Boutrel ◽  
...  
Keyword(s):  
Dorsal Raphe ◽  
Corticotropin Releasing Factor ◽  
Self Administration ◽  
Extended Access ◽  
Dorsal Raphé

scholarly journals Impact of Extended Access Methamphetamine, Cocaine, and MDPV Self‐administration on Recognition Memory in Rats

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Robert Seaman ◽  
Agnieszka Sulima ◽  
Kenner Rice ◽  
Gregory Collins
Keyword(s):  
Recognition Memory ◽  
Self Administration ◽  
Extended Access
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