scholarly journals Impact of Extended Access Methamphetamine, Cocaine, and MDPV Self‐administration on Recognition Memory in Rats

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Robert Seaman ◽  
Agnieszka Sulima ◽  
Kenner Rice ◽  
Gregory Collins
Keyword(s):  
Recognition Memory ◽  
Self Administration ◽  
Extended Access

scholarly journals Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akhil Sharma ◽  
Arman Harutyunyan ◽  
Bernard L. Schneider ◽  
Anna Moszczynska
Keyword(s):  
Neural Substrates ◽  
Genetically Engineered ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Self Administration ◽  
Methamphetamine Use ◽  
New Therapeutic Approaches ◽  
Extended Access ◽  
High Doses ◽  
Methamphetamine Use Disorder

AbstractThere is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target for METH use disorder. PARKIN knockout, PARKIN-overexpressing, and wild-type young adult male Long Evans rats were trained to self-administer high doses of METH using an extended-access METH self-administration paradigm. Reinforcing/rewarding properties of METH were assessed by quantifying drug-taking behavior and time spent in a METH-paired environment. PARKIN knockout rats self-administered more METH and spent more time in the METH-paired environment than wild-type rats. Wild-type rats overexpressing PARKIN self-administered less METH and spent less time in the METH-paired environment. PARKIN knockout rats overexpressing PARKIN self-administered less METH during the first half of drug self-administration days than PARKIN-deficient rats. The results indicate that rats with PARKIN excess or PARKIN deficit are useful models for studying neural substrates underlying “resilience” or vulnerability to METH use disorder and identify PARKIN as a novel potential drug target to treat heavy use of METH.

scholarly journals Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats

2011 ◽  
Vol 17 (2) ◽  
pp. 300-308 ◽  
Author(s):  
Eric P. Zorrilla ◽  
Sunmee Wee ◽  
Yu Zhao ◽  
Sheila Specio ◽  
Benjamin Boutrel ◽  
...  
Keyword(s):  
Dorsal Raphe ◽  
Corticotropin Releasing Factor ◽  
Self Administration ◽  
Extended Access ◽  
Dorsal Raphé

Drug specificity in extended access cocaine and heroin self-administration

2011 ◽  
Vol 17 (6) ◽  
pp. 964-976 ◽  
Author(s):  
Magalie Lenoir ◽  
Karyn Guillem ◽  
George F. Koob ◽  
Serge H. Ahmed
Keyword(s):  
Self Administration ◽  
Extended Access

scholarly journals Nicotine Self-administration Is Not Increased in the Methylazoxymethanol Acetate Rodent Model of Schizophrenia

2019 ◽  
Vol 22 (2) ◽  
pp. 204-212 ◽  
Author(s):  
Jillian J Weeks ◽  
Laura E Rupprecht ◽  
Anthony A Grace ◽  
Eric C Donny ◽  
Alan F Sved
Keyword(s):  
Animal Model ◽  
General Population ◽  
Gold Standard ◽  
Rodent Model ◽  
Schedules Of Reinforcement ◽  
Self Administration ◽  
Methylazoxymethanol Acetate ◽  
Valid Model ◽  
Extended Access ◽  
And Control

Abstract Introduction Patients with schizophrenia (SCZ) smoke at a rate of 4–5 times higher than the general population, contributing to negative health consequences in this group. One possible explanation for this increased smoking is that individuals with SCZ find nicotine (NIC) more reinforcing. However, data supporting this possibility are limited. Methods The present experiments examined self-administration of NIC, alone or in combination with other reinforcers, across a range of doses in the methylazoxymethanol acetate (MAM) rodent model of SCZ. Results MAM and control animals did not differ in NIC self-administration across a range of doses and schedules of reinforcement, in both standard 1-hour self-administration sessions and 23-hour extended access sessions. However, MAM animals responded less for sucrose or reinforcing visual stimuli alone or when paired with NIC. Conclusions To the extent that MAM-treated rats are a valid model of SCZ, these results suggest that increased NIC reinforcement does not account for increased smoking in SCZ patients. Implications This study is the first to utilize nicotine self-administration, the gold standard for studying nicotine reinforcement, in the methylazoxymethanol acetate model of schizophrenia, which is arguably the most comprehensive animal model of the disease currently available. Our assessment found no evidence of increased nicotine reinforcement in methylazoxymethanol acetate animals, suggesting that increased reinforcement may not perpetuate increased smoking in schizophrenia patients.

scholarly journals Extended access oxycodone self-administration and neurotransmitter receptor gene expression in the dorsal striatum of adult C57BL/6 J mice

2013 ◽  
Vol 231 (7) ◽  
pp. 1277-1287 ◽  
Author(s):  
Yong Zhang ◽  
Brandan Mayer-Blackwell ◽  
Stefan D. Schlussman ◽  
Matthew Randesi ◽  
Eduardo R. Butelman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Receptor Gene ◽  
Dorsal Striatum ◽  
Self Administration ◽  
Neurotransmitter Receptor ◽  
Extended Access ◽  
Receptor Gene Expression
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