scholarly journals Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior

2018 ◽  
Vol 235 (6) ◽  
pp. 1821-1833 ◽  
Author(s):  
L. Broccoli ◽  
S. Uhrig ◽  
G. von Jonquieres ◽  
K. Schönig ◽  
D. Bartsch ◽  
...  
Keyword(s):  
Receptor Subtype ◽  
Central Amygdala ◽  
Seeking Behavior ◽  
Alcohol Seeking

scholarly journals Matrix Metalloproteinase-9 and Synaptic Plasticity in the Central Amygdala in Control of Alcohol-Seeking Behavior

2017 ◽  
Vol 81 (11) ◽  
pp. 907-917 ◽  
Author(s):  
Marzena Stefaniuk ◽  
Anna Beroun ◽  
Tomasz Lebitko ◽  
Olga Markina ◽  
Szymon Leski ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Central Amygdala ◽  
Seeking Behavior ◽  
Metalloproteinase 9 ◽  
Alcohol Seeking

scholarly journals Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1919
Author(s):  
Hannah S. Ballas ◽  
Samantha M. Wilfur ◽  
Nicole A. Freker ◽  
Kah-Chung Leong
Keyword(s):  
Male Rats ◽  
Emotional Impact ◽  
Central Amygdala ◽  
Self Administration ◽  
Concurrent Administration ◽  
Neural Structure ◽  
Oxytocin Receptors ◽  
Seeking Behavior ◽  
As Stress ◽  
Alcohol Seeking

Factors such as stress and anxiety often contribute to alcohol-dependent behavior and can trigger a relapse of alcohol addiction and use. Therefore, it is important to investigate potential pharmacological interventions that may alleviate the influence of stress on addiction-related behaviors. Previous studies have demonstrated that the neuropeptide oxytocin has promising anxiolytic potential in mammals and may offer a pharmacological target to diminish the emotional impact on reinstatement of alcohol-seeking. The purpose of the present study was to investigate the effect of oxytocin on stress-induced alcohol relapse and identify a neural structure mediating this effect through the use of an ethanol self-administration and yohimbine-induced reinstatement paradigm. While yohimbine administration resulted in the reinstatement of ethanol-seeking behavior, the concurrent administration of yohimbine and oxytocin attenuated this effect, suggesting that oxytocin may disrupt stress-induced ethanol-seeking behavior. The central amygdala (CeA) is a structure that drives emotional responses and robustly expresses oxytocin receptors. Intra-CeA oxytocin similarly attenuated the yohimbine-induced reinstatement of ethanol-seeking behavior. These results demonstrate that oxytocin has the potential to attenuate stress-induced relapse into ethanol-seeking behavior, and that this mechanism occurs specifically within the central amygdala.

Baclofen attenuates cue-induced reinstatement of alcohol-seeking behavior in Sardinian alcohol-preferring (sP) rats

2008 ◽  
Vol 95 (3) ◽  
pp. 284-287 ◽  
Author(s):  
Paola Maccioni ◽  
Przemyslaw Bienkowski ◽  
Mauro A.M. Carai ◽  
Gian Luigi Gessa ◽  
Giancarlo Colombo
Keyword(s):  
Seeking Behavior ◽  
Alcohol Seeking

scholarly journals Prefrontal Cortex K Ca 2 Channels Regulate mGlu 5 -Dependent Plasticity and Extinction of Alcohol-Seeking Behavior

2017 ◽  
Vol 37 (16) ◽  
pp. 4359-4369 ◽  
Author(s):  
Reginald Cannady ◽  
Justin T. McGonigal ◽  
Ryan J. Newsom ◽  
John J. Woodward ◽  
Patrick J. Mulholland ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dependent Plasticity ◽  
Seeking Behavior ◽  
Alcohol Seeking

Intracerebroventricular administration of galanin or galanin receptor subtype 1 agonist M617 induces c-Fos activation in central amygdala and dorsomedial hypothalamus

Peptides ◽  
2007 ◽  
Vol 28 (5) ◽  
pp. 1120-1124 ◽  
Author(s):  
Alice Blackshear ◽  
Mihoko Yamamoto ◽  
Brenda J. Anderson ◽  
Philip V. Holmes ◽  
Linda Lundström ◽  
...  
Keyword(s):  
Receptor Subtype ◽  
Intracerebroventricular Administration ◽  
Central Amygdala ◽  
Galanin Receptor ◽  
Dorsomedial Hypothalamus

The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats

2000 ◽  
Vol 150 (3) ◽  
pp. 317-324 ◽  
Author(s):  
A. D. Lê ◽  
S. Harding ◽  
W. Juzytsch ◽  
J. Watchus ◽  
U. Shalev ◽  
...  
Keyword(s):  
Corticotrophin Releasing Factor ◽  
Seeking Behavior ◽  
Alcohol Seeking
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