Intratumoral injection of dendritic and irradiated glioma cells induces anti-tumor effects in a mouse brain tumor model

2002 ◽  
Vol 51 (8) ◽  
pp. 424-430 ◽  
Author(s):  
Tetsuro Kikuchi ◽  
Yasuharu Akasaki ◽  
Toshiaki Abe ◽  
Tsuneya Ohno
Keyword(s):  
Brain Tumor ◽  
Mouse Brain ◽  
Glioma Cells ◽  
Tumor Model ◽  
Intratumoral Injection ◽  
Brain Tumor Model

Antitumor Effect of Immunizations With Fusions of Dendritic and Glioma Cells in a Mouse Brain Tumor Model

2001 ◽  
Vol 24 (2) ◽  
pp. 106-113 ◽  
Author(s):  
Yasuharu Akasaki ◽  
Tetsuro Kikuchi ◽  
Sadamu Homma ◽  
Toshiaki Abe ◽  
Donald Kofe ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Mouse Brain ◽  
Antitumor Effect ◽  
Glioma Cells ◽  
Tumor Model ◽  
Brain Tumor Model

scholarly journals Examination of blood–brain barrier (BBB) integrity in a mouse brain tumor model

2012 ◽  
Vol 111 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Ngoc H. On ◽  
Ryan Mitchell ◽  
Sanjot D. Savant ◽  
Corbin. J. Bachmeier ◽  
Grant M. Hatch ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Blood Brain Barrier ◽  
Mouse Brain ◽  
Tumor Model ◽  
Brain Barrier ◽  
Blood Brain ◽  
Brain Tumor Model

scholarly journals Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro

2012 ◽  
Vol 3 ◽  
pp. 166-174 ◽  
Author(s):  
Emanuela Binello ◽  
Zulekha A. Qadeer ◽  
Harini P. Kothari ◽  
Luni Emdad ◽  
Isabelle M. Germano
Keyword(s):  
Brain Tumor ◽  
Mouse Brain ◽  
Tumor Model ◽  
Immunocompetent Mouse ◽  
Brain Tumor Model

SU-F-500-10: Targeted Delivery of Microbeam Irradiation and Initial Mouse Brain Tumor Model Studies Using a Table Top MRT System

2013 ◽  
Vol 40 (6Part23) ◽  
pp. 384-385
Author(s):  
L Zhang ◽  
H Yuan ◽  
M Hadsell ◽  
L Burk ◽  
C Inscoe ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Mouse Brain ◽  
Targeted Delivery ◽  
Tumor Model ◽  
Microbeam Irradiation ◽  
Model Studies ◽  
Brain Tumor Model

scholarly journals Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model

2015 ◽  
Vol 21 (15) ◽  
pp. 3462-3470 ◽  
Author(s):  
Ren-Yuan Bai ◽  
Verena Staedtke ◽  
Teresia Wanjiku ◽  
Michelle A. Rudek ◽  
Avadhut Joshi ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Mouse Brain ◽  
Tumor Model ◽  
Brain Penetration ◽  
Brain Tumor Model

scholarly journals CD9 Expression in Solid Non-neuroepithelial Tumors and Infiltrative Astrocytic Tumors

2002 ◽  
Vol 50 (9) ◽  
pp. 1195-1203 ◽  
Author(s):  
Masatou Kawashima ◽  
Katsumi Doh-ura ◽  
Eisuke Mekada ◽  
Masashi Fukui ◽  
Toru Iwaki
Keyword(s):  
Brain Tumor ◽  
Malignant Gliomas ◽  
Glioma Cells ◽  
Tumor Model ◽  
Surrounding Tissue ◽  
Low Grade ◽  
Astrocytic Tumors ◽  
Neuroepithelial Tumors ◽  
Brain Tumor Model ◽  
Murine Brain

The tetraspan membrane protein CD9 is normally expressed in the mature myelin sheath and is believed to suppress the metastatic potential of certain human tumors. In this study we identified CD9 in a variety of brain tumors by immunohistochemical (IHC) and immunoblotting analyses. We examined 96 tumor samples and three glioma cell lines in addition to a murine brain tumor model of transplanted glioma cells in CD9-deficient mice and control mice. CD9 was expressed not only in solid non-neuroepithelial tumors but also in infiltrative malignant neuroepithelial tumors. Among the neuroepithelial tumors, high-grade astrocytic tumors, including glioblastomas and anaplastic astrocytomas, showed higher immunoreactivity than low-grade cerebral astrocytomas. Thus, CD9 expression in astrocytic tumors correlated with their malignancy. In the murine brain tumor model, transplanted glioma cells were shown to grow and spread through myelinated areas irrespective of the presence or absence of CD9 expression in the recipient's brain. These results indicate that the CD9 expression of astrocytic tumors plays a significant role in the malignancy independent of CD9 expression in the surrounding tissue. This might be explained by the observation that the CD9 molecule is associated with a mitogenic factor, membrane-anchored heparin-binding epidermal growth factor, which is known to be upregulated in malignant gliomas.

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