Introduction. Allogeneic stem-cell transplantation is only potentially
curative therapy for variety of hematology malignancies, such as acute and
chronic leukemia, myelodisplastic syndrome and aplastic anemia, but also
promising treatment option for other disorders. If we know that only 25% of
patients have an human leukocyte antigen identical sibling donor, it is
obvious that matched unrelated donor hematopoietic stem cell transplantation
is an alternative for the rest of the patients. Material and Methods. Since
2013, matched unrelated donor hematopoietic stem cell transplantation has
been performed routinely in the Military Medical Academy. Results. We hereby
present the outcome after 77 procedures in 75 patients. Considering primary
diseases, 35 patients had acute myeloid leukemia, 25 patients had acute
lymphoid leukemia, 5 patients had chronic myeloid leukemia, 9 patients had
myelodisplastic syndrome and we performed the transplant on 1 patient with
chronic lymphocyte leukemia, 1 patient with aplastic anemia and 1 patient
with T lymphoblastic lymphoma. Conclusion. It is difficult to make clear
conclusions based on this heterogeneous group of patients, but it seems that
these results are encouraging. Future research will be performed to evaluate
matched unrelated donor and identical sibling hematopoietic stem cell
transplantation in the homogenous groups with respect to primary diseases.
Matched unrelated donor hematopoietic stem cell transplantation - our results
