Preliminary Results
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2021 ◽  
Vol 8 ◽  
Poornima Oruganti ◽  
Rehmat Awan ◽  
Xianzhong Ding ◽  
Michael Wesolowski ◽  
Ayokunle T. Abegunde

Microscopic colitis (MC) is a common cause of chronic diarrhea with limited long-term data. We searched the pathology records at our institution from 2008 to 2018 to identify cases of MC. Total sample included patients with either a diagnosis of MC or incomplete MC (MCi).Chart review was performed and data were summarized for descriptive statistics. Logistic regression was used to estimate the unadjusted effects of predictors on MC. A total of 216 patients (88.32% white, 80.56% females, mean age 67.12 +/– 15.79) were studied; 50.00% had CC, 40.28% had LC and 9.72% had MCi. Majority (52.31%) were smokers and 21.84% of females were using some form of hormonal therapy. The odds of LC in reference to CC were significantly higher for those using tricyclic antidepressants (TCAs) (OR: 3.23, 95% C.I: 1.18–8.80, p = 0.02). The odds of smoking, statins, aspirin and beta-blocker use were decreased in MCi in reference to CC (all p < 0.05), 29 (74.35%) patients with unresolved symptoms underwent repeat colonoscopies with biopsies. One case of MCi resolved, 8 (72.73%) out of 11 cases of LC resolved, 2 (18.18%) continued to be LC and 1 (9.09%) transformed to CC, 8 (47.06%) out of 17 cases of CC resolved, 8 (47.06%) continued to be CC and 1 (5.88%) transformed to LC. Majority of patients had CC. TCA use resulted in increased odds of LC in reference to CC. Biopsies from repeat colonoscopies in some patients revealed changes in the pathological diagnoses raising the question of interchangeability of MC (CC to LC and vice versa).

Crystals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1140
Sylvain Le Tonquesse ◽  
Yoshitaka Matsushita ◽  
Priyanka Jood ◽  
Michihiro Ohta ◽  
Takao Mori ◽  

CrSi2 is a promising thermoelectric material constituted of non-toxic and earth abundant elements that offer good perspectives for the mass production of inexpensive and reliable thermoelectric modules for waste heat recovery. Realization of robust metallic contacts with low electrical and thermal resistances on thermoelectric materials is crucial to maximize the conversion efficiency of such a device. In this article, the metallization of an undoped CrSi2 with Ti and Nb using a conventional Spark Plasma Sintering process is explored and discussed. These contact metals were selected because they have compatible thermal expansion coefficients with those of CrSi2, which were determined in this study by X-ray Diffraction in the temperature range 299–899 K. Ti was found to be a promising contact metal offering both strong adhesion on CrSi2 and negligible electrical contact resistance (<1 μΩ cm2). However, metallization with Nb resulted in the formation of cracks caused by large internal stress inside the sample during the fabrication process and the diffusion of Si in the metallic layer. A maximum conversion efficiency of 0.3% was measured for a sandwiched Ti/CrSi2/Ti thermoelectric leg placed inside a thermal gradient of 427 K. The preliminary results obtained and discussed in this article on a relatively simple case study aim to initiate the development of more reliable and efficient CrSi2 thermoelectric legs with an optimized design.

Energies ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5929
Magdalena Kapłan ◽  
Kamila Klimek ◽  
Serhiy Syrotyuk ◽  
Ryszard Konieczny ◽  
Bartłomiej Jura ◽  

The article reviews selected methods and techniques of agricultural biogas desulphurization. Presented is the current state of technological and measurement systems as well as raw biogas purification methods in terms of control and measurement-socio-economic aspects were also pointed out. On the example of a pilot agricultural biogas with the use of pig slurry, the required technical and technological criteria for the production and processing of agricultural biogas were indicated. The article presents the preliminary results of experimental studies on the course of changes in the volumetric composition of biogas on the basis of the average daily production of agricultural biogas. The amount of H2S in raw and purified biogas was analyzed with the proprietary biogas desulphurization method in terms of the process parameters. A novelty is the use of a developed carbon mixture (activated carbon) with turf ore (iron compounds), which allows for 100% desulfurization of raw agricultural biogas under process conditions for mesophilic fermentation. The measurement results show a clear influence of desulphurization using the proprietary adsorption-absorption technique-agricultural biogas.

Wesley Monroe Shrum ◽  
Jonathan Teye Yevuyibor ◽  
Shriya Thakkar

Prior research has shown that mental health in urban slums is associated with the a share number of older individuals in personal networks. This presentation will examine the extent to which that association is mediated through Internet and social media use. We conducted face to face interviews with residents (minimum 18 years) in two high density, low income areas of Accra (West Africa) and Trivandrum (Kerala, India), where local teams have conducted repeated studies of personal networks since 1994. Our preliminary results show that mobile phones are primary way in which respondents communicate with members of their core networks. Further preliminary results show that while research in high income areas has generally shown the importance of larger networks for positive mental health, our analysis of urban slums reveals a different pattern. First, there is no general association of larger networks with reduced symptoms of anxiety and depression. Second, one particular group of relationships is strongly associated with depression and anxiety: ties with older individuals. The questions we explore are: (1) To what extent are indicators of mental health related to indicators of Internet and social media usage? (2) To what extent are indicators of mental health related to indicators of social network size and composition? (3) To what extent are indicators of Internet and social media usage related to indicators of indicators of social network size and composition?

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3210
Germán Alberto Nolasco-Rosales ◽  
José Jaime Martínez-Magaña ◽  
Isela Esther Juárez-Rojop ◽  
Thelma Beatriz González-Castro ◽  
Carlos Alfonso Tovilla-Zarate ◽  

Eating disorders are psychiatric disorders characterized by disturbed eating behaviors. They have a complex etiology in which genetic and environmental factors interact. Analyzing gene-environment interactions could help us to identify the mechanisms involved in the etiology of such conditions. For example, comethylation module analysis could detect the small effects of epigenetic interactions, reflecting the influence of environmental factors. We used MethylationEPIC and Psycharray microarrays to determine DNA methylation levels and genotype from 63 teenagers with eating disorders. We identified 11 comethylation modules in WGCNA (Weighted Gene Correlation Network Analysis) and correlated them with single nucleotide polymorphisms (SNP) and clinical features in our subjects. Two comethylation modules correlated with clinical features (BMI and height) in our sample and with SNPs associated with these phenotypes. One of these comethylation modules (yellow) correlated with BMI and rs10494217 polymorphism (associated with waist-hip ratio). Another module (black) was correlated with height, rs9349206, rs11761528, and rs17726787 SNPs; these polymorphisms were associated with height in previous GWAS. Our data suggest that genetic variations could alter epigenetics, and that these perturbations could be reflected as variations in clinical features.

Riccardo Miceli McMillan

Abstract Psychedelic-assisted psychotherapy is an emerging psychiatric treatment that is attracting significant scientific, medical, and public attention. Whilst preliminary results from empirical studies are promising, the medical use of these compounds is highly controversial. Surprisingly, and despite the current controversies caused by the re-medicalisation of psychedelics, bioethicists have remained mysteriously silent. This paper aims to stimulate further bioethical reflection regarding the re-medicalisation of psychedelics. The current paper aims to do this by applying a normative phenomenological lens of analysis. Namely, this paper applies Martin Heidegger's critique of modern technology, and Fredrik Svenaeus' extension of this critique, to the re-medicalisation of psychedelics. I argue that when this critique of modern technology is applied several normative issues become apparent. Specifically, it becomes apparent that the re-medicalisation of psychedelics risks turning the ecological sources, cultural contexts, and experiences induced by psychedelics into resources to be exploited for human goals; all of which risks endangering ecosystems, appropriating traditional knowledge, and reducing the therapeutic effects of psychedelic-assisted psychotherapy. Furthermore, I suggest that preserving non-reductionist, non-instrumentalising traditional ways of understanding psychedelic compounds is essential in mitigating these consequences. More discussion by bioethicists is necessary as these consequences represent important global challenges for the psychedelic renaissance that require immediate addressing.

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5592
Antonio Monopoli ◽  
Michele Casiello ◽  
Pietro Cotugno ◽  
Antonella Milella ◽  
Fabio Palumbo ◽  

The aim of the present work is the synthesis and characterization of new perfluorinated monomers bearing, similarly to Nafion®, acidic groups for proton transport for potential and future applications in proton exchange membrane (PEM) fuel cells. To this end, we focused our attention on the synthesis of various molecules with (i) sufficient volatility to be used in vacuum polymerization techniques (e.g., PECVD)), (ii) sulfonic, phosphonic, or carboxylic acid functionalities for proton transport capacity of the resulting membrane, (iii) both aliphatic and aromatic perfluorinated tags to diversify the membrane polarity with respect to Nafion®, and (iv) a double bond to facilitate the polymerization under vacuum giving a preferential way for the chain growth of the polymer. A retrosynthetic approach persuaded us to attempt three main synthetic strategies: (a) organometallic Heck-type cross-coupling, (b) nucleophilic displacement, and (c) Wittig–Horner reaction (carbanion approach). Preliminary results on the plasma deposition of a polymeric film are also presented. The variation of plasma conditions allowed us to point out that the film prepared in the mildest settings (20 W) shows the maximum monomer retention in its structure. In this condition, plasma polymerization likely occurs mainly by rupture of the π bond in the monomer molecule.

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