First in human: the effects of biventricular pacing on cardiac output in severe pulmonary arterial hypertension

2019 ◽  
Vol 35 (6) ◽  
pp. 852-858
Author(s):  
Ahmet Afşin Oktay ◽  
Stacy A. Mandras ◽  
Sangeeta Shah ◽  
Krishna Kancharla ◽  
Omar F. Shams ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Biventricular Pacing ◽  
Pulmonary Arterial ◽  
Severe Pulmonary Arterial Hypertension

scholarly journals Transition from selexipag to oral treprostinil in a patient with pulmonary arterial hypertension

2020 ◽  
Vol 10 (1) ◽  
pp. 204589401989803 ◽  
Author(s):  
Ifeoma Oriaku ◽  
Amol Patel ◽  
Zeenat Safdar
Keyword(s):  
Cardiac Output ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Maximum Dose ◽  
Mixed Venous Oxygen Saturation ◽  
Maximal Dose ◽  
Venous Oxygen Saturation ◽  
Pulmonary Arterial ◽  
Mixed Venous ◽  
Severe Pulmonary Arterial Hypertension

Prostacyclins are the mainstay treatment for patients with severe pulmonary arterial hypertension. This case highlights the transition from selexipag to oral treprostinil. Our patient improved both subjectively and objectively. Cardiac output and index, as measured by the echocardiogram, improved 12% and 7.7%, respectively. Invasive hemodynamic data revealed greater improvements: cardiac output improved by 25% and cardiac index by 28%. Mixed venous oxygen saturation improved from 65% to 71%. A possible explanation is that selexipag has a maximal dose, whereas there is no recommended maximum dose of oral treprostinil. Another theory is oral treprostinil has higher affinity to the IP receptor, though selexipag has a higher specificity. However, there are no bio-equivalency data, and data comparing pharmacodynamics of both drugs are lacking. Furthermore, no head-to-head trials comparing these agents exist.

scholarly journals Severe Pulmonary Arterial Hypertension in Patients Treated for Hepatitis C With Sofosbuvir

CHEST Journal ◽  
2016 ◽  
Vol 149 (3) ◽  
pp. e69-e73 ◽  
Author(s):  
Sébastien Renard ◽  
Patrick Borentain ◽  
Erwan Salaun ◽  
Sanaa Benhaourech ◽  
Baptiste Maille ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Arterial ◽  
Severe Pulmonary Arterial Hypertension
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