Heart and Vessels
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Published By Springer-Verlag

1615-2573, 0910-8327

2022 ◽  
Tetsuji Morishita ◽  
Hiroyasu Uzui ◽  
Kaori Hisazaki ◽  
Yasuhiko Mitsuke ◽  
Taketoshi Yamazaki ◽  

2022 ◽  
Jakob Ledwoch ◽  
Jana Kraxenberger ◽  
Anna Krauth ◽  
Alisa Schneider ◽  
Katharina Leidgschwendner ◽  

AbstractHigh-sensitive troponin T (hs-TnT) is increasingly used for prognostication in patients with acute heart failure (AHF). However, uncertainty exists whether hs-TnT shows comparable prognostic performance in patients with heart failure and different classes of left ventricular ejection fraction (LV-EF). The aim of the present study was to assess the prognostic value of hs-TnT for the prediction of 30-day mortality depending on the presence of HF with preserved ejection fraction (HFpEF), HF with mid-range LV-EF (HFmrEF) and HF with reduced LV-EF (HFrEF) in patients with acutely decompensated HF. Patients admitted to our institution due to AHF were retrospectively included. Clinical information was gathered from electronic and paper-based patient charts. Patients with myocardial infarction were excluded. A total of 847 patients were enrolled into the present study. A significant association was found between HF groups and hs-TnT (regression coefficient -0.018 for HFpEF vs. HFmrEF/HFrEF; p = 0.02). The area under the curve (AUC) of hs-TnT for the prediction of 30-mortality was significantly lower in patients with HFpEF (AUC 0.61) than those with HFmrEF (AUC 0.80; p = 0.01) and HFrEF (AUC 0.73; p = 0.04). Hs-TnT was not independently associated with 30-day outcome in the HFpEF group (OR 1.48 [95%-CI 0.89–2.46]; p = 0.13) in contrast to the HFmrEF group (OR 4.53 [95%-CI 1.85–11.1]; p < 0.001) and HFrEF group (OR 2.58 [95%-CI 1.57–4.23]; p < 0.001). Prognostic accuracy of hs-TnT in patients hospitalized for AHF regarding 30-day mortality is significantly lower in patients with HFpEF compared to those with HFmrEF and HFrEF.

2022 ◽  
Khlood Ahmed ◽  
Yuichiro Arima ◽  
Noriaki Tabata ◽  
Masanobu Ishii ◽  
Ryota Sato ◽  

2022 ◽  
Tetsuya Hieda ◽  
Yasushige Shingu ◽  
Satoshi Sugimoto ◽  
Hidetsugu Asai ◽  
Tomoji Yamakawa ◽  

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