Investigation of retinal nerve fiber layer thickness and ganglion cell layer-inner plexiform layer thickness in patients with optic pathway gliomas

2018 ◽  
Vol 256 (9) ◽  
pp. 1757-1765 ◽  
Author(s):  
Mustafa Hepokur ◽  
Ahmet Murat Sarici
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Optic Pathway ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Optic Pathway Gliomas

Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly

2016 ◽  
Vol 37 (3) ◽  
pp. 591-598 ◽  
Author(s):  
Muhammed Şahin ◽  
Alparslan Şahin ◽  
Faruk Kılınç ◽  
Harun Yüksel ◽  
Zeynep Gürsel Özkurt ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retina Ganglion Cell

scholarly journals Investigation of the pathophysiology of the retina and choroid in Parkinson's disease by optical coherence tomography

2021 ◽  
Author(s):  
Yasuaki Kamata ◽  
Naoto Hara ◽  
Tsukasa Satou ◽  
Takahiro Niida ◽  
Kazuo Mukuno
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Luminal Area

Abstract Purpose The pathology of Parkinson's disease (PD) is suspected to affect the retina and choroid. We investigated changes in the retina and choroid of patients with PD using optical coherence tomography. Methods We examined 14 patients with PD and 22 patients without PD. Patients without PD had no ophthalmic disease other than cataracts. In addition, it was also confirmed that there was no neurodegenerative disease. The retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and choroidal thickness were compared between both groups. Additionally, the choroidal image was divided into the choroid area, luminal area, and interstitial area using the binarization method, and the area of each region and the percentage of luminal area in the choroid area were analyzed. Results Patients with PD had a significantly thinner ganglion cell layer + inner plexiform layer compared to those without PD. The choroid area, luminal area, and interstitial area were significantly decreased in patients with PD compared to those without PD. Seven patients with PD who were successfully followed up showed decreased retinal nerve fiber layer and interstitial area after 3 years. Conclusion Autonomic nervous disorders and neurodegeneration in PD can cause thinning of the retina and choroid, as well as a reduction in the choroid area.

scholarly journals Retinal Sensitivity and Ganglion Cell-Related Retinal Layer Thickness in the Normal Aging Process 

2021 ◽  
Author(s):  
Makoto Araie ◽  
Makoto Fujii ◽  
Yuko Ohno ◽  
Yuki Tanaka ◽  
Tsutomu Kikawa ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Plexiform Layer ◽  
Retinal Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Ocular Media

Abstract Aging-associated changes in visual field (VF) sensitivity were compared prospectively and longitudinally with the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell-inner plexiform layer thickness (GCIPLT) changes in the corresponding retinal areas of the same eyes (72 eyes of 37 normal Japanese subjects; mean age, 51.3 years). The Humphrey Field Analyzer 24-2 test (HFA 24-2) and spectral-domain optical coherence tomography (SD-OCT) measurements of the cpRNFLT and GCIPLT in a 0.6-mm-diameter circle corresponding to the four central points of HFA 24-2 adjusted for retinal ganglion cell displacement (GCIPLT4TestPoints) were performed every 3 months for 3 years. The tiem changes of the mean sensitivity over the entire field (VFmean) and the four central points (VF4TestPoints), cpRNFLT, and GCIPLT4TestPoints were analyzed using a linear mixed model. The aging-associated decline rates of VFmean and VF4TestPoins were 0.12 and 0.19 decibels/year (p<0.001), which significantly accelerated with increased subjects’ age (0.009 and 0.010 decibels/year, p<0.001, respectively) without changes in the ocular media. Those of the CpRNFLT and GCIPLT4TestPoints were not significant in both (p>0.114), but significantly accelerated with increased subjects’ age (0.021 and 0.010 mm/year, p=0.001 and 0.004, respectively). These results have implications in studying physiological aging- or desease-related changes in these parameters.

Investigation of the Pathophysiology of the Retina and Choroid in Parkinson's Disease by Optical Coherence Tomography

2021 ◽  
Author(s):  
Yasuaki Kamata ◽  
Naoto Hara ◽  
Tsukasa Satou ◽  
Takahiro Niida ◽  
Kazuo Mukuno
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Luminal Area

Abstract PurposeThe pathology of Parkinson's disease (PD) is suspected to affect the retina and choroid. We investigated changes in the retina and choroid of patients with PD using optical coherence tomography (OCT).MethodsWe examined 14 patients with PD and 22 patients without PD. Patients without PD had no ophthalmic pathology other than cataracts and neurodegenerative disorders. The retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and choroidal thickness were compared between both groups. Additionally, the choroidal image was divided into the choroid area, luminal area, and interstitial area using the binarization method, and the area of each region and the percentage of luminal area in the choroid area was analyzed. ResultsPatients with PD had a significantly thinner ganglion cell layer + inner plexiform layer compared to those without PD. The choroid area, luminal area, and interstitial area were significantly decreased in patients with PD compared to those without PD. Seven patients with PD who were successfully followed-up for 3 years showed decreased retinal nerve fiber layer and interstitial area after 3 years.ConclusionAutonomic nervous disorders and neurodegeneration in PD can cause thinning of the retina and choroid, as well as a reduction of the choroid area.

Decreases in ganglion cell layer and inner plexiform layer volumes correlate better with disease severity in schizophrenia patients than retinal nerve fiber layer thickness: Findings from spectral optic coherence tomography

2016 ◽  
Vol 32 ◽  
pp. 9-15 ◽  
Author(s):  
M. Celik ◽  
A. Kalenderoglu ◽  
A. Sevgi Karadag ◽  
O. Bekir Egilmez ◽  
B. Han-Almis ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Disease Severity ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Plexiform Layer ◽  
Optic Coherence Tomography ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Treatment Refractory

AbstractBackgroundOptic coherence tomography (OCT) is a new, contactless and fast neuroimaging method. Previous studies have observed thinning of the retinal nerve fibre layer (RNFL) in many neurodegenerative diseases, and researchers have suggested that correlations exist between the thinning of the RNFL and the neurodegeneration detected with other imaging methods or the severity of illness. More recently, OCT has been used in patients with schizophrenia. RNFL thinning has also been detected in these patients. With more sophisticated devices, segmentation of the retina and measurements of the ganglion cell layer (GCL) and internal plexiform layer (IPL) can be performed.MethodsWe measured the RNFL thickness and the GCL and IPL volumes in 40 treatment refractory patients with schizophrenia, 41 treatment responsive refractory patients and 41 controls using spectral-OCT, and we evaluated the correlations between the disease severity and OCT measurements.ResultsThe global RNFL thickness and GCL and IPL volumes were decreased in the patients with schizophrenia compared with the controls. In addition, the GCL and IPL volumes were lower in the treatment refractory patients with schizophrenia compared to the treatment responsive patients. Using parameters such as the Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) scores, the disease duration and number of hospitalizations, correlations between the GCL and IPL volumes and disease severity were stronger than the correlations between the RNFL and the disease parameters.ConclusionOur findings suggest that OCT can be used to detect neurodegeneration in schizophrenia and that the GCL and IPL volumes can also be used to monitor the progression of neurodegeneration.

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