Visualization of microaneurysms in macular telangiectasia type 1 on optical coherence tomography angiography before and after photocoagulation

Abstract Purpose To evaluate changes in the visualization of microaneurysms (MAs) in cases of macular telangiectasia (Mac Tel) type 1 on optical coherence tomography angiography (OCTA) before and after treatment with direct photocoagulation and to evaluate their relationship with treatment efficacy. Methods The study included 12 eyes from 12 patients (8 men, 4 women; mean age 72.1 years) with Mac Tel type 1 accompanied by cystoid macular edema. OCTA for the evaluation of MAs was performed before and 15 min and 6, 12, and 24 weeks after photocoagulation. The best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were also evaluated. Results A total of 73 MAs were detected within the areas of macular edema on OCTA, and 39 of these underwent photocoagulation. At 15 min after treatment, 17 MAs were no longer visible on OCTA. At 6 weeks, two MAs had reappeared, whereas five additional MAs were no longer visible. The CRT in eyes with resolved MA was significantly less than that in eyes with persistent MAs (p = 0.016). At 24 weeks, seven eyes had no visible MAs, and the BCVA was not significantly different from baseline. Conclusion OCTA can monitor changes in the visualization of MAs associated with Mac Tel type 1 after direct photocoagulation. Eyes in which MAs disappeared after treatment could recover from cystoid macular edema.

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Optical coherence tomography angiography of macular telangiectasia type 1: Comparison with mild diabetic macular edema

Lasers in Surgery and Medicine ◽

10.1002/lsm.22645 ◽

2017 ◽

Vol 49 (3) ◽

pp. 225-232 ◽

Cited By ~ 9

Author(s):

Lei Mao ◽

Si-si Weng ◽

Yuan-yuan Gong ◽

Su-qin Yu

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Macular Telangiectasia

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ACUTE PSEUDOPHAKIC CYSTOID MACULAR EDEMA IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Retina ◽

10.1097/iae.0000000000001829 ◽

2018 ◽

Vol 38 (10) ◽

pp. 2073-2080 ◽

Cited By ~ 8

Author(s):

Mardoche Chetrit ◽

Sophie Bonnin ◽

Valérie Mané ◽

Ali Erginay ◽

Ramin Tadayoni ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence

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Effect of Hemodialysis on Retinal Thickness in Patients with Diabetic Retinopathy, with and without Macular Edema, Using Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2014/709862 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Nur Azem ◽

Oriel Spierer ◽

Meital Shaked ◽

Meira Neudorfer

Keyword(s):

Blood Pressure ◽

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Macular Edema ◽

Retinal Thickness ◽

Optical Coherence ◽

Before And After ◽

Stage Renal Disease ◽

End Stage ◽

Esrd Patients

Background.Effects of hemodialysis (HD) treatment on retinal thickness and macular edema are unclear.Objective.To evaluate changes in retinal thickness using optical coherence tomography (OCT) in end stage renal disease (ESRD) patients with diabetic retinopathy (DR), with and without diabetic macular edema (DME), undergoing HD.Methods.Nonrandomized prospective study. Forty eyes of DR patients with ESRD treated with HD were divided into two groups: patients with macular edema and patients without macular edema. Both eyes were analyzed. Patients underwent an ophthalmic examination including OCT measurements of retinal thickness, blood albumin and hemoglobin A1C levels, blood pressure, and body weight, 30 minutes before and after HD.Results.We found no significant effects of HD on retinal thickness among patients both with and without DME. The former showed a trend towards reduction in retinal thickness in foveal area following HD, while the latter showed an increase. There was no correlation between retinal thickness and mean blood pressure, weight, kinetic model value—Kt/V, glycemic hemoglobin, or albumin levels before and after HD.Conclusions.HD has no significant effect on retinal thickness among patients with or without DME. Further studies on larger cohorts and repeated OCT examinations are needed to confirm the preliminary findings in this study.

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Microvascular Changes In The Recurrent Cystoid Macular Edema Secondary to Posterior Noninfectious Uveitis on Optical Coherence Tomography Angiography

10.21203/rs.3.rs-790122/v1 ◽

2021 ◽

Author(s):

Valeria Albano ◽

Silvana Guerriero ◽

Claudio Furino ◽

Giancarlo Sborgia ◽

Alessandra Sborgia ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Optical Coherence Tomography Angiography ◽

Posterior Uveitis ◽

Foveal Avascular Zone ◽

Optical Coherence ◽

Microvascular Changes ◽

Capillary Rarefaction ◽

Deep Layers

Abstract BACKGROUND: Posterior uveitis represents the second most frequent type of uveitis (15-30% of all uveitis). Non-infectious posterior uveitis complicated with secondary cystoid macular edema (CME) negatively affected the visual prognosis.The objective of the current study is to determine possible microvascular changes that can cause a relapsing uveitis-CME through optical coherence tomography angiography (OCTA).METHODS: This is a case-control study, an evaluation of patients with secondary CME noninfectious posterior uveitis-related undergoing dexamethasone (DEX) implant. The visits following the DEX-implant were carried out after 1 month, 2-months, 4-months, 6-months, and for up 1-year. A total of 76 eyes of 38 consecutive patients with noninfectious posterior uveitis were enrolled (consecutive sample). Complicated noninfectious posterior uveitis with secondary CME was diagnosed in 56 eyes of uveitis patients (24.3%) reviewed. RESULTS: Our investigation showed a reduction in superficial vessel plexus (SVP) measurements already within 2-month (84%), reaching 96.4% for up 1-year, however displaying an irregular profile in 69.6% of cases, persisting for up 1-year; the relapsing uveitis-CME eyes with irregular superficial foveal avascular zone (FAZ) profile were in 51%, while the SVP measurements reestablished in 100% of cases. Conversely, the deep vascular plexus (DVP) parameters restored occurred in a lower number of eyes within the 2-month (39.3%), remaining abnormal in 46.4% of cases for up 1-year; despite DVP restored in 53.6% of cases for up 1 year, a capillary rarefaction ring around the FAZ appeared in 80.4% of cases; the relapsing uveitis-CME eyes with abnormal DVP parameters were in 41% of cases, of which 92.1% showed a rarefaction ring had abnormal DVP.CONCLUSIONS: The use of OCTA allows to evaluate the retinal microvascular features, which could be the cause of the recurrence of CME in uveitis patients, despite the DEX-implant treatment. We suggested that the possibility of the recurrence of the uveitis-CME depends on the persistence of modifications of the superficial and deep layers, which we therefore consider appropriate to investigate. With this purpose it would be useful to introduce OCTA into the current imaging armamentarium in follow-up of patients with noninfectious uveitis-CME.

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