Therapeutic effect of tirilazad mesylate (U-74006F), mannitol, and their combination on experimental ischemia

2000 ◽  
Vol 199 (4) ◽  
pp. 231-242 ◽  
Author(s):  
I. Suat Öktem ◽  
Ahmet Menkü ◽  
Hidayet Akdemir ◽  
Olgun Kontaş ◽  
Ali Kurtsoy ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Tirilazad Mesylate

Improvement of SSPE after carbamazepine: natural course or therapeutic effect?

2010 ◽  
Vol 41 (02) ◽  
Author(s):  
M Schimmel ◽  
J Penzien
Keyword(s):  
Therapeutic Effect ◽  
Natural Course

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

1994 ◽  
Vol 71 (06) ◽  
pp. 768-772 ◽  
Author(s):  
Gerhard Dickneite ◽  
Jörg Czech
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Organ Failure ◽  
Therapeutic Effect ◽  
Disseminated Intravascular Coagulation ◽  
Post Infection ◽  
Thrombin Inhibitor ◽  
Bolus Administration ◽  
Bacterial Burden ◽  
Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

MR imaging of intracranial tuberculosis: Emphasis on development of lesions and therapeutic effect

1993 ◽  
Vol 29 (6) ◽  
pp. 1121
Author(s):  
Kook Sang Han ◽  
Chang Hyo Sol ◽  
Young Joon Lee ◽  
Chang Ho Choi ◽  
Sang Ook Kim ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Therapeutic Effect

Percutaneous Ethanol Ablation of Hepatic and Renal Cyst: Therapeutic Effect and Follow-Up Study

1994 ◽  
Vol 30 (2) ◽  
pp. 253 ◽  
Author(s):  
Seog Hee Park ◽  
Kyung Sub Shinn ◽  
Ki Tae Kim ◽  
Seong Tae Hahn ◽  
Choon Yul Kim ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Renal Cyst ◽  
Ethanol Ablation ◽  
Follow Up Study

Therapeutic Effect of Epidural Steroid Injection in Patients Suspected of having an Internal Disc Disruption: A Prospective Case Study

2007 ◽  
Vol 57 (3) ◽  
pp. 281
Author(s):  
Na Ra Kim ◽  
Joon Woo Lee ◽  
Sang-Ki Chung ◽  
Ki-Jeong Kim ◽  
Hyun-Jib Kim ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Steroid Injection ◽  
Epidural Steroid Injection ◽  
Epidural Steroid

Clinical and microbiological aspects of vaginal microbiota at pregnant with threat of late miscarriages during treatment with vaginal gestagens forms

2017 ◽  
pp. 68-73
Author(s):  
I.P. Polishchuk ◽  
Keyword(s):  
Pregnant Women ◽  
Therapeutic Effect ◽  
Local Treatment ◽  
Vaginal Microbiota ◽  
Control Group ◽  
Before And After ◽  
Low Efficiency ◽  
Late Miscarriage ◽  
Microbiological Aspects ◽  
Micronized Progesterone

The objective: was to examine the effectiveness of treatment of late miscarriage threat by micronized form of progesterone for 100 mg – 3 times a day in the form of gelatin pills and vaginal tablets with lactose. Patients and methods. Under our supervision there were 70 pregnant women with normocenosis of vagina (NCV) without extragenital pathology, which were not performed systemic or local treatment with antibacterial drugs in the last 4 weeks. Among them 25 pregnant women with TLSM treated by gelatin tablets of micronized progesterone (GTP) (group 1); 25 pregnant women with TLSM, treated by vaginal micronized progesterone tablets (VPT) (2nd group) and 20 healthy women with physiological pregnancy – PV (control group). The distribution of women in the group adhered to the principles of randomization. The age of examined women ranged from 19 to 32 years, most pregnant women were aged under 30 years (89.02%). General clinical examination was carried out according to the standard scheme according to the Order MH of Ukraine № 620. Results. During the research we have determined the colpocytologcal dynamics and state of vaginal microbiota in pregnant women with threatened late miscarriage with initial vaginal normocenosis before and after treatment whit vaginal forms of progesterone. Conclusion. The received results showed low efficiency of micronized progesterone gelatin dragee at threat of the late miscarriage that at small therapeutic effect has led to the development of vaginal dysbiosis in all surveyed. In contrast, the use of micronized progesterone vaginal tablets – the maximally rapid therapeutic effect without disturbance of vaginal normocenosis. Key words: the threat of a late miscarriage, vaginal micronized forms of progesterone.

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