Mesh fixation using novel bio-adhesive coating compared to tack fixation for IPOM hernia repair: in vivo evaluation in a porcine model

We present an animal model used to evaluate the in vivo performance of electrochemical amperometric continuous lactate sensors compared to blood gas instruments. Electrochemical lactate sensors were fabricated, placed into 5 Fr central venous catheters (CVCs), and paired with wireless potentiostat devices. Following in vivo evaluation and calibration, sensors were placed within the jugular and femoral veins of a porcine subject as a preliminary assessment of in vivo measurement accuracy. The mobile electronic circuit potentiostat devices supplied the operational voltage for the sensors, measured the resultant steady-state current, and recorded the sensor response values in internal memory storages. An in vivo time trace of implanted intravenous (IV) sensors demonstrated lactate values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. Currents measured continuously from the implanted lactate sensors over 10 h were converted into lactate concentration values through use of a two-point in vivo calibration. Study shows that intravenously implanted sensors had more accurate readings, faster peak-reaching rates, and shorter peak-detection times compared to subcutaneously placed sensors. IV implanted and subcutaneously placed sensors closer to the upper body (in this case neck) showed faster response rates and more accurate measurements compared to those implanted in the lower portion of the porcine model. This study represents an important milestone not only towards continuous lactate monitoring for early diagnosis and intervention in neonatal patients with congenital heart disease undergoing cardiopulmonary bypass surgeries, but also in the intervention of critical ill patients in the Intensive Care Units or during complex surgical procedures.

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In vivo evaluation of a new composite mesh (10% polypropylene/90% poly-l-lactic acid) for hernia repair

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-006-0090-1 ◽

2007 ◽

Vol 18 (6) ◽

pp. 991-999 ◽

Cited By ~ 14

Author(s):

Keitaro Tanaka ◽

Didier Mutter ◽

Harutaka Inoue ◽

Véronique Lindner ◽

George Bouras ◽

...

Keyword(s):

Lactic Acid ◽

Hernia Repair ◽

Composite Mesh ◽

In Vivo Evaluation

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Abstract 2241: Direct Visualization Of The Fossa Ovalis For Transeptal Puncture: In Vivo Evaluation Of The IRIS Catheter In A Porcine Model

Circulation ◽

10.1161/circ.116.suppl_16.ii_488-a ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Aravinda Thiagalingam ◽

Andre d’Avila ◽

Lori Foley ◽

David Miller ◽

Chris Rothe ◽

...

Keyword(s):

Porcine Model ◽

De Novo ◽

Interatrial Septum ◽

Intracardiac Echocardiography ◽

Atrial Septum ◽

Post Mortem ◽

Direct Visualization ◽

Atrial Wall ◽

In Vivo Evaluation

Introduction: Transeptal puncture is required for many interventional procedures but has a serious complication rate of ~1%. The primary risk of the procedure is related to mis-identification of the interatrial septum resulting in inadvertant puncture of the aorta or the atrial wall into the pericardium. We have investigated the utility of a catheter that allows direct visualization of the fossa ovalis to correctly position the transseptal needle at the interatrial septum. Methods: This study included 6 swine. The IRIS catheter (Voyage Medical, Campbell, CA) enables direct visualization using a cone-shaped hood into which saline is infused to exclude blood. In 4/6 animals, intracardiac echocardiography was used to visualize, but not guide, the transeptal puncture; there was no visible tenting of the septum. After transeptal puncture was performed the IRIS catheter was used to directly visualize and cannulate the puncture sites. Results: In 5 animals, transeptal puncture was successfully performed repeatedly (2–4 punctures/animal), and a .035 guidwire passed into the left atrium. IRIS could also guide cannulation of previous puncture in these animals. In 1 animal, visualization could not be performed because the atrial septum was lacerated during an attempt at left atrial visualization via a patent foramen ovale. Pericardial effusion was only observed in this latter animal on post-mortem exam. IRIS visualization of the atrial septum correlated well with the pathological specimen (see Figure ). Conclusion: The IRIS catheter allows direct in vivo visualization of the interatrial septum to guide de novo transeptal puncture or cannulation of previous punctures. Top: A cascade of in vivo IRIS images of transeptal puncture holes (arrows) and a PFO Bottom: Corresponding post mortem speciman

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In vivo evaluation of argon plasma coagulation in a porcine model

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2006.09.005 ◽

2007 ◽

Vol 65 (3) ◽

pp. 457-462 ◽

Cited By ~ 24

Author(s):

Christopher J. Goulet ◽

James A. DiSario ◽

Lyska Emerson ◽

Kristen Hilden ◽

Richard Holubkov ◽

...

Keyword(s):

Porcine Model ◽

Argon Plasma Coagulation ◽

Argon Plasma ◽

In Vivo Evaluation ◽

Plasma Coagulation

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Validation of Single C-Arm Fluoroscopic Technique for Measuring In Vivo Abdominal Wall Deformation

Journal of Biomechanical Engineering ◽

10.1115/1.4037073 ◽

2017 ◽

Vol 139 (8) ◽

Cited By ~ 5

Author(s):

Lindsey G. Kahan ◽

Charlotte Guertler ◽

Jeffrey A. Blatnik ◽

Spencer P. Lake

Keyword(s):

Hernia Repair ◽

Abdominal Wall ◽

Test Piece ◽

Porcine Model ◽

Recurrence Rates ◽

Mesh Placement ◽

Wall Deformation ◽

Determine System ◽

System Movement

Hernia meshes significantly reduce the recurrence rates in hernia repair. It is known that they affect the abdominal wall postimplantation, yet the understanding of in vivo mechanics in the mesh placement area is lacking. We established a single C-arm biplane fluoroscopic system to study strains at the interface between the mesh and repaired abdominal tissues. We aimed to validate this system for future porcine hernia repair studies. Custom matlab programs were written to correct for pincushion distortion, and direct linear transformation (DLT) reconstructed objects in 3D. Using a custom biplane-trough setup, image sets were acquired throughout the calibrated volume to evaluate a radio-opaque test piece with known distances between adjacent beads. Distances were measured postprocessing and compared to known measurements. Repeatability testing was conducted by taking image sets of the test piece in a fixed location to determine system movement. The error in areal stretch tracking was evaluated by imaging a square plate with fixed radio-opaque beads and using matlab programs to compare the measured areal stretch to known bead positions. Minor differences between measured and known distances in the test piece were not statistically different, and the system yielded a 0.01 mm bias in the XY plane and a precision of 0.61 mm. The measured areal stretch was 0.996, which was not significantly different than the expected value of 1. In addition, preliminary stretch data for a hernia mesh in a porcine model demonstrated technique feasibility to measure in vivo porcine abdominal mechanics.

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Homogeneous biodegradable ureteral stent: In vivo evaluation in a porcine model

European Urology Supplements ◽

10.1016/s1569-9056(18)32441-2 ◽

2018 ◽

Vol 17 (4) ◽

pp. e2018

Author(s):

A. Barros ◽

C. Oliveira ◽

A. Jacinta ◽

R. Autorino ◽

R. Reis ◽

...

Keyword(s):

Porcine Model ◽

Ureteral Stent ◽

In Vivo Evaluation

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In vivo evaluation of the delivery and efficacy of a sirolimus-laden polymer gel for inhibition of hyperplasia in a porcine model of arteriovenous hemodialysis graft stenosis

Journal of Controlled Release ◽

10.1016/j.jconrel.2012.03.011 ◽

2012 ◽

Vol 160 (3) ◽

pp. 459-467 ◽

Cited By ~ 20

Author(s):

Christi M. Terry ◽

Li Li ◽

Huan Li ◽

Ilya Zhuplatov ◽

Donald K. Blumenthal ◽

...

Keyword(s):

Porcine Model ◽

Polymer Gel ◽

In Vivo Evaluation ◽

Graft Stenosis ◽

Hemodialysis Graft

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Longer 6-mm Diameter Stent Retrievers Are Effective for Achieving Higher First Pass Success with Fibrin-Rich Clots

Interventional Neurology ◽

10.1159/000499974 ◽

2019 ◽

Vol 8 (2-6) ◽

pp. 187-195 ◽

Cited By ~ 2

Author(s):

Gaurav Girdhar ◽

Evan Epstein ◽

Kevin Nguyen ◽

Chelsea Gregg ◽

Tejashri Kumar ◽

...

Keyword(s):

Porcine Model ◽

Anterior Circulation ◽

In Vivo Evaluation ◽

Vessel Occlusion ◽

In Vivo Models ◽

Guide Catheter ◽

First Pass ◽

Stent Retrievers

First pass success (FPS) can be defined as in vitro retrieval of clot in a single pass during mechanical thrombectomy (MT) for acute large vessel occlusion (LVO). Despite advancements in MT technology, retrieval of fibrin-rich clots remains a challenge. Therefore, the effect of stent retriever length on FPS for fibrin-rich clots was investigated by using SolitaireTM 6 × 40 versus 6 × 30 mm devices with a balloon guide catheter (BGC) or distal access catheter (DAC) and sheath, in an in vitro model of anterior circulation neurovascular anatomy. Additionally, vascular safety of the SolitaireTM 6 × 40 versus 6 × 30 mm devices was evaluated in a porcine model for differences in: luminal thrombus, inflammation, endothelial coverage, fibrin deposits, smooth muscle cell loss, elastic lamina and adventitia disruption, intimal hyperplasia, and lumen reduction, at 0, 30, and 90 days post-treatment. In vitro overall FPS was measured as: SolitaireTM 6 × 40 (95%) and SolitaireTM 6 × 30 (67%). FPS for clot location in middle cerebral artery was: (a) BGC (6 × 40 mm: 100%; 6 × 30 mm: 100%; n = 8); (b) DAC with 088 sheath (6 × 40 mm: 83%; 6 × 30 mm: 33%; n = 12). FPS for clot location in internal carotid artery was: (a) BGC (6 × 40 mm: 100%; 6 × 30 mm: 80%; n = 11); (b) DAC with 088 sheath (6 × 40 mm: 100%; 6 × 30 mm: 67%; n = 10). Stent length had a significant effect (Fisher’s exact test; p < 0.05) on FPS. In vivo evaluation in the porcine model showed no difference in vascular safety parameters between the SolitaireTM 6 × 40 and 6 × 30 mm devices (p > 0.05) at all time points in the study. Longer stent retrievers may be safe and effective in improving FPS for fibrin-rich clots in in vitro and in vivo models of LVO.

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