Vascular complications of diabetes: natural history and corresponding risks of dementia in a national cohort of adults with diabetes

2021 ◽  
Author(s):  
Po-Yin Chang ◽  
I.-T.ing Wang ◽  
Chern-En Chiang ◽  
Chen-Huan Chen ◽  
Wan-Yu Yeh ◽  
...  
Keyword(s):  
Natural History ◽  
Vascular Complications ◽  
Complications Of Diabetes ◽  
National Cohort

L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes

2020 ◽  
Vol 27 (11) ◽  
pp. 1744-1763 ◽  
Author(s):  
Stefano Menini ◽  
Carla Iacobini ◽  
Claudia Blasetti Fantauzzi ◽  
Giuseppe Pugliese
Keyword(s):  
Diabetic Nephropathy ◽  
Life Quality ◽  
Vascular Complications ◽  
Carbonyl Stress ◽  
Complications Of Diabetes ◽  
Diabetic Vascular Complications ◽  
Reactive Carbonyl Species ◽  
Stage Renal Disease ◽  
Stress Dependent ◽  
End Stage

Vascular complications are among the most serious manifestations of diabetes. Atherosclerosis is the main cause of reduced life quality and expectancy in diabetics, whereas diabetic nephropathy and retinopathy are the most common causes of end-stage renal disease and blindness. An effective therapeutic approach to prevent vascular complications should counteract the mechanisms of injury. Among them, the toxic effects of Advanced Glycation (AGEs) and Lipoxidation (ALEs) end-products are well-recognized contributors to these sequelae. L-carnosine (β-alanyl-Lhistidine) acts as a quencher of the AGE/ALE precursors Reactive Carbonyl Species (RCS), which are highly reactive aldehydes derived from oxidative and non-oxidative modifications of sugars and lipids. Consistently, L-carnosine was found to be effective in several disease models in which glyco/lipoxidation plays a central pathogenic role. Unfortunately, in humans, L-carnosine is rapidly inactivated by serum carnosinase. Therefore, the search for carnosinase-resistant derivatives of Lcarnosine represents a suitable strategy against carbonyl stress-dependent disorders, particularly diabetic vascular complications. In this review, we present and discuss available data on the efficacy of L-carnosine and its derivatives in preventing vascular complications in rodent models of diabetes and metabolic syndrome. We also discuss genetic findings providing evidence for the involvement of the carnosinase/L-carnosine system in the risk of developing diabetic nephropathy and for preferring the use of carnosinase-resistant compounds in human disease. The availability of therapeutic strategies capable to prevent both long-term glucose toxicity, resulting from insufficient glucoselowering therapy, and lipotoxicity may help reduce the clinical and economic burden of vascular complications of diabetes and related metabolic disorders.

Vascular complications of diabetes mellitus: what role for phospholipid-binding antibodies?

Lupus ◽  
1998 ◽  
Vol 7 (7) ◽  
pp. 469-474 ◽  
Author(s):  
F Galtier-Dereure ◽  
C Biron ◽  
M Vies ◽  
V Bourgeois ◽  
J-F Schved ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Complications ◽  
Complications Of Diabetes ◽  
Phospholipid Binding

scholarly journals Vascular Complications of Diabetes- Retinal and Renal Changes in Diabetic Foot

2020 ◽  
Vol 7 (6) ◽  
pp. 275-279
Author(s):  
Prajeesh Thiru Chaithanya ◽  
Sreejayan Meethala Parambil ◽  
Rajan Puthiadath
Keyword(s):  
Diabetic Foot ◽  
Vascular Complications ◽  
Complications Of Diabetes ◽  
Renal Changes

Endothelial Progenitor Cell Dysfunction in the Pathogenesis of Vascular Complications of Diabetes

2017 ◽  
pp. 159-208
Author(s):  
Nicoleta Alexandru ◽  
Irina Titorencu ◽  
Sabina Frunzã ◽  
Emma Weiss ◽  
Elisabeta Bãdilã ◽  
...  
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Vascular Complications ◽  
Endothelial Progenitor ◽  
Complications Of Diabetes ◽  
Cell Dysfunction
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