6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis

2021 ◽  
Author(s):  
Xiaofang Zhu ◽  
Hao Yuan ◽  
Ouyang Ningjuan ◽  
Carroll Ann Trotman ◽  
Thomas E. Van Dyke ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Signaling Axis

The role of osteocytes in bone resorption during orthodontic tooth movement

2014 ◽  
Vol 73 (4) ◽  
pp. 112-113
Author(s):  
Tsutomu Matsumoto ◽  
Tadahiro Iimura ◽  
Kenji Ogura ◽  
Keiji Moriyama ◽  
Akira Yamaguchi
Keyword(s):  
Bone Resorption ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement

The Role of Osteocytes in Bone Resorption during Orthodontic Tooth Movement

2013 ◽  
Vol 92 (4) ◽  
pp. 340-345 ◽  
Author(s):  
T. Matsumoto ◽  
T. Iimura ◽  
K. Ogura ◽  
K. Moriyama ◽  
A. Yamaguchi
Keyword(s):  
Bone Resorption ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement

scholarly journals Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Liviu Feller ◽  
Razia A. G. Khammissa ◽  
George Thomadakis ◽  
Jeanine Fourie ◽  
Johan Lemmer
Keyword(s):  
Bone Resorption ◽  
Periodontal Ligament ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Precursor Cells ◽  
Signalling Pathways ◽  
Mechanical Forces ◽  
Complex Interactions ◽  
External Root Resorption

Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions between signalling pathways activated by various biological agents. Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root resorption there is repair by cellular cementum, but factors mediating the transition from resorption to repair are not clear. In this paper we review some of the biological events associated with orthodontically induced external root resorption.

scholarly journals TGF-β1 Stimulates Bone Resorption during Orthodontic Tooth Movement

2020 ◽  
Vol 19 (3) ◽  
pp. 193-199
Author(s):  
Jun Kikuta ◽  
Michiko Tsukada ◽  
Katsuma Takagi ◽  
Mami Shimizu ◽  
Takuji Hikida ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement

Effects of Prostaglandin E2 on Alveolar Bone Resorption during Orthodontic Tooth Movement

1988 ◽  
Vol 132 (4) ◽  
pp. 304-309 ◽  
Author(s):  
Chung-Fu Chao ◽  
Chung Shih ◽  
Teen-Meei Wang ◽  
Tai-Hua Lo
Keyword(s):  
Bone Resorption ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Prostaglandin E

scholarly journals Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats

2016 ◽  
pp. cjw038 ◽  
Author(s):  
Takeshi Kurohama ◽  
Hitoshi Hotokezaka ◽  
Megumi Hashimoto ◽  
Takako Tajima ◽  
Kotaro Arita ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement

scholarly journals Wnt5a Stimulates Bone Resorption during Orthodontic Tooth Movement

2019 ◽  
Vol 17 (3-4) ◽  
pp. 62-68
Author(s):  
Jun Kikuta ◽  
Hitomi Saito-Goto ◽  
Takehiro Iwane ◽  
Mami Shimizu ◽  
Takuji Hikida ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement

The role of HIF-1α in nicotine-induced root and bone resorption during orthodontic tooth movement

2020 ◽  
Author(s):  
Niklas Ullrich ◽  
Agnes Schröder ◽  
Maria Bauer ◽  
Gerrit Spanier ◽  
Jonathan Jantsch ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Alternative Mechanism ◽  
Periodontal Ligament Fibroblasts ◽  
Expression Ratio ◽  
Trabecular Thickness ◽  
Study Results

Summary Background In orthodontic tooth movement (OTM), pseudo-inflammatory processes occur that are similar to those of nicotine-induced periodontitis. Previous studies have shown that nicotine accelerates OTM, but induces periodontal bone loss and dental root resorption via synergistically increased osteoclastogenesis. This study aimed to investigate the role of hypoxia-inducible factor 1 alpha (HIF-1α) in nicotine-induced osteoclastogenesis during OTM. Materials/Methods Male Fischer-344 rats were treated with l-Nicotine (1.89 mg/kg/day s.c., N = 10) or NaCl solution (N = 10). After a week of premedication, a NiTi spring was inserted to mesialize the first upper left molar. The extent of dental root resorption, osteoclastogenesis, and HIF-1α protein expression was determined by (immuno)histology, as well as bone volume (BV/TV) and trabecular thickness (TbTh) using µCT. Receptor activator of nuclear factor of activated B-cells ligand (RANK-L), osteoprotegerin (OPG), and HIF-1α expression were examined at the protein level in periodontal ligament fibroblasts (PDLF) exposed to pressure, nicotine and/or hypoxia, as well as PDLF-induced osteoclastogenesis in co-culture experiments with osteoclast progenitor cells. Results Nicotine favoured dental root resorptions and osteoclastogenesis during OTM, while BV/TV and TbTh were only influenced by force. This nicotine-induced increase does not appear to be mediated by HIF-1α, since HIF-1α was stabilized by force application and hypoxia, but not by nicotine. The in vitro data showed that the hypoxia-induced increase in RANK-L/OPG expression ratio and PDLF-mediated osteoclastogenesis was less pronounced than the nicotine-induced increase. Conclusions Study results indicate that the nicotine-induced increase in osteoclastogenesis and periodontal bone resorption during OTM may not be mediated by hypoxic effects or HIF-1α stabilization in the context of nicotine-induced vasoconstriction, but rather by an alternative mechanism.

Periodontal Ligament Remodeling and Alveolar Bone Resorption During Orthodontic Tooth Movement in Rats with Diabetes

2010 ◽  
Vol 12 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Xin Li ◽  
Lin Zhang ◽  
Na Wang ◽  
Xiaohong Feng ◽  
Liangjia Bi
Keyword(s):  
Bone Resorption ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement
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