Efficacy of the dual-action GA-KR12 peptide for remineralising initial enamel caries: an in vitro study

2021 ◽  
Author(s):  
John Yun Niu ◽  
Iris Xiaoxue Yin ◽  
William Ka Kei Wu ◽  
Quan-Li Li ◽  
May Lei Mei ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Enamel Caries ◽  
Dual Action

Remineralization of early enamel caries lesions using different bioactive elements containing toothpastes: An in vitro study

2016 ◽  
Vol 24 (5) ◽  
pp. 701-711 ◽  
Author(s):  
Yu Wang ◽  
Li Mei ◽  
Lin Gong ◽  
Jialing Li ◽  
Shaowei He ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Enamel Caries ◽  
Caries Lesions

scholarly journals Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

2004 ◽  
Vol 48 (10) ◽  
pp. 4006-4008 ◽  
Author(s):  
Jim Zhen Wu ◽  
Gary Larson ◽  
Zhi Hong
Keyword(s):  
Hepatitis C ◽  
Viral Infection ◽  
Nucleoside Analogue ◽  
In Vitro Study ◽  
Vitro Study ◽  
Action Mechanism ◽  
Nucleoside Phosphorylase ◽  
Dual Action

ABSTRACT An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to ribavirin for the treatment of hepatitis C viral infection. We have reported that viramidine mainly functions as a prodrug of ribavirin that is enriched in the liver. This in vitro study further explores viramidine's activity against nucleoside phosphorylase, a host enzyme that is responsible for phosphorolysis of ribavirin in vivo. Our experiments show that viramidine inhibits ribavirin phosphorolysis with a Ki of 2.5 μM. This result suggests that viramidine may act through a dual-action mechanism by serving as a prodrug of ribavirin and concomitantly as an inhibitor for nucleoside phosphorylase catabolism of ribavirin.

Monitoring enamel caries on resin-treated occlusal surfaces using quantitative light-induced fluorescence: an in vitro study

2020 ◽  
Vol 35 (7) ◽  
pp. 1629-1636 ◽  
Author(s):  
Florense Gabriela Silva ◽  
Patricia Moreira Freitas ◽  
Fausto Medeiros Mendes ◽  
Tatiane Fernandes de Novaes ◽  
Michele Baffi Diniz ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Enamel Caries ◽  
Occlusal Surfaces

scholarly journals Role of Candida species from HIV infected children in enamel caries lesions: an in vitro study

2017 ◽  
Vol 25 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Senda CHARONE ◽  
◽  
Maristela Barbosa PORTELA ◽  
Karol de Oliveira MARTINS ◽  
Rosangela Maria SOARES ◽  
...  
Keyword(s):  
Candida Species ◽  
In Vitro Study ◽  
Vitro Study ◽  
Enamel Caries ◽  
Caries Lesions
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