Unusual Difference in Enantioselectivity of Two Chiral Stationary Phases with Grafted Antibiotic Ristocetin A

2021 ◽  
Vol 84 (3) ◽  
pp. 307-311
Author(s):  
Margarita V. Kopchenova ◽  
Maria V. Stepanova ◽  
Leonid D. Asnin
Keyword(s):  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Ristocetin A

scholarly journals Adsorption of Binary Solvents on Chiral Stationary Phases with Grafted Macrocyclic Antibiotics

2021 ◽  
Vol 95 (11) ◽  
pp. 2304-2309
Author(s):  
Ya. A. Klimova ◽  
L. D. Asnin
Keyword(s):  
Stationary Phases ◽  
Molecular Layer ◽  
Chiral Stationary Phases ◽  
Binary Solvents ◽  
First Case ◽  
Ristocetin A ◽  
Adsorption Of Water ◽  
Macrocyclic Antibiotics ◽  
Molecular Layers ◽  
Quantitative Indicators

Abstract A study is performed of the adsorption of water–methanol and water–acetonitrile mixtures on chiral stationary phases (CSPs) Chirobiotic R, Chirobiotic T, and Nautilus-E with grafted macrocyclic antibiotics ristocetin A, teicoplanin, and eremomycin, respectively. The patterns of adsorption on the indicated CSPs are qualitatively the same, and differ only by quantitative indicators. Adsorption isotherms of excess water from binary solvents have adsorption azeotrope points and show the preferred absorption of water in the range of pure organic component to an azeotrope point in the range of 60–75 mol % for H2О–МеОН and 80–90 mol % for H2O–MeCN systems. It is shown that the thickness of the adsorption phase in the first case is less than one nominal molecular layer (0.10–0.13 nm). For H2O–MeCN, it is 3–4 molecular layers (0.88–1.05 nm). Activity coefficients are calculated for the components of solutions in surface layers. The coefficients indicate the systems deviate considerably from the properties of an ideal adsorption solution. Reasons for this behavior are discussed.

Enantioseparation of 3α-acyloxy-6β-acetoxyltropane compounds with Chiralpak AD and Chiralcel OD-H chiral stationary phases

2015 ◽  
Vol 33 (6) ◽  
pp. 647
Author(s):  
Bin CHENG ◽  
Yifan XIE ◽  
Youmin HU ◽  
Huizhong LIU ◽  
Yinyao NIU ◽  
...  
Keyword(s):  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Chiralcel Od

Original enantioseparation of illicit fentanyls with cellulose-based chiral stationary phases under polar-ionic conditions

2021 ◽  
Vol 1643 ◽  
pp. 462088
Author(s):  
Ina Varfaj ◽  
Michele Protti ◽  
Marco Cirrincione ◽  
Andrea Carotti ◽  
Laura Mercolini ◽  
...  
Keyword(s):  
Stationary Phases ◽  
Chiral Stationary Phases

Evaluation of six chiral stationary phases in LC for their selectivity towards drug enantiomers

1992 ◽  
Vol 10 (10-12) ◽  
pp. 895-908 ◽  
Author(s):  
Christel Vandenbosch ◽  
De´sire´Luc Massart ◽  
Wolfgang Lindner
Keyword(s):  
Stationary Phases ◽  
Chiral Stationary Phases
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