scholarly journals Role of Dynamic Loading on Early Stage of Bone Fracture Healing

2018 ◽  
Vol 46 (11) ◽  
pp. 1768-1784 ◽  
Author(s):  
Smriti Ghimire ◽  
Saeed Miramini ◽  
Martin Richardson ◽  
Priyan Mendis ◽  
Lihai Zhang
Keyword(s):  
Fracture Healing ◽  
Dynamic Loading ◽  
Bone Fracture ◽  
Early Stage ◽  
Bone Fracture Healing

PREDICTION OF THE TREND OF BONE FRACTURE HEALING BASED ON THE RESULTS OF THE EARLY STAGES SIMULATIONS: A FINITE ELEMENT STUDY

2019 ◽  
Vol 19 (05) ◽  
pp. 1950021
Author(s):  
JALIL NOURISA ◽  
GHOLAMREZA ROUHI
Keyword(s):  
Finite Element ◽  
Fracture Healing ◽  
Bone Fracture ◽  
Mechanical Stability ◽  
Early Stage ◽  
Healing Process ◽  
Fibrous Tissue ◽  
Fe Model ◽  
Bone Fracture Healing ◽  
Early Stages

To date, several studies have implied the importance of early stage mechanical stability in the bone fracture healing process. This study aimed at finding a correlation between the predicted different tissue phenotypes in the early stages of healing and the ultimate healing outcome. For this purpose, the process of fracture healing was numerically simulated employing an axisymmetric bi-phasic finite element (FE) model for three initial gap sizes of 1, 3 and 6[Formula: see text]mm and four initial interfragmentary strains (IFS) of 7%, 11%, 15% and 19%. The model was validated with experimental and other numerical studies from the literature. Results of this study showed that the amount of cartilage and fibrous tissue observed in the early stage after fracture can be used to qualitatively assess the outcome of complete bone healing process. Greater amount of cartilage in early stage of healing process yielded faster callus maturation, and delayed maturation of callus was predicted in the case of high fibrous tissue production. Results of this study can be used to provide an estimation of the performance of different fixation systems by considering the amounts of cartilage and fibrous tissues observed in the early stage of healing.

Role of Platelet-Rich Plasma in Acceleration of Bone Fracture Healing

2008 ◽  
Vol 61 (3) ◽  
pp. 337-344 ◽  
Author(s):  
Richard Simman ◽  
Andrea Hoffmann ◽  
R Jordan Bohinc ◽  
Wylan C. Peterson ◽  
Andrew J. Russ
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Platelet Rich Plasma ◽  
Bone Fracture Healing

scholarly journals Role of Platelet‐Rich Plasma in Acceleration of Bone Fracture Healing

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Wylan Cornelius Peterson ◽  
Rudy Jordan Bohinc ◽  
Andrea Hoffmann ◽  
Harold F Stills ◽  
Richard Simman
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Platelet Rich Plasma ◽  
Bone Fracture Healing

scholarly journals Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation

2020 ◽  
Vol 13 (11) ◽  
pp. dmm043620 ◽  
Author(s):  
Jiang-Hua Liu ◽  
Tao Yue ◽  
Zhong-Wei Luo ◽  
Jia Cao ◽  
Zi-Qi Yan ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Systemic Inflammation ◽  
Bone Healing ◽  
Bone Fracture ◽  
Early Stage ◽  
Gut Permeability ◽  
Bone Fracture Healing ◽  
Gut Barrier ◽  
Vessel Formation ◽  
Akkermansia Muciniphila

ABSTRACTImproving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this study, fractured mice intragastrically administrated with A. muciniphila were found to display better fracture healing than mice treated with vehicle. Notably, more preosteclasts positive for platelet-derived growth factor-BB (PDGF-BB) were induced by A. muciniphila at 2 weeks post fracture, coinciding with increased formation of type H vessels, a specific vessel subtype that couples angiogenesis and osteogenesis, and can be stimulated by PDGF-BB. Moreover, A. muciniphila treatment significantly reduced gut permeability and inflammation at the early stage. Dextran sulfate sodium (DSS) was used to disrupt the gut barrier to determine its role in fracture healing and whether A. muciniphila still can stimulate bone fracture healing. As expected, A. muciniphila evidently improved gut barrier, reduced inflammation and restored the impaired bone healing and angiogenesis in DSS-treated mice. Our results suggest that A. muciniphila reduces intestinal permeability and alleviates inflammation, which probably induces more PDGF-BB+ preosteoclasts and type H vessel formation in callus, thereby promoting fracture healing. This study provides the evidence for the involvement of type H vessels in fracture healing and suggests the potential of A. muciniphila as a promising strategy for bone healing.This article has an associated First Person interview with the first author of the paper.

scholarly journals The crucial role of neutrophil granulocytes in bone fracture healing

2016 ◽  
Vol 32 ◽  
pp. 152-162 ◽  
Author(s):  
A Kovtun ◽  
◽  
S Bergdolt ◽  
R Wiegner ◽  
P Radermacher ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Crucial Role ◽  
Neutrophil Granulocytes ◽  
Bone Fracture Healing
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