Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions

2008 ◽  
Vol 23 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Li Xing ◽  
Ravi G. Kurumbail ◽  
Ronald B. Frazier ◽  
Michael S. Davies ◽  
Hideji Fujiwara ◽  
...  
Keyword(s):  
Structural Model ◽  
Prostaglandin E ◽  
Inhibitor Binding ◽  
Binding Interactions ◽  
Prostaglandin E Synthase ◽  
Substrate Inhibitor ◽  
Microsomal Prostaglandin E Synthase

scholarly journals Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors

2016 ◽  
Vol 26 (19) ◽  
pp. 4824-4828 ◽  
Author(s):  
Steven L. Kuklish ◽  
Stephen Antonysamy ◽  
Shobha N. Bhattachar ◽  
Srinivasan Chandrasekhar ◽  
Matthew J. Fisher ◽  
...  
Keyword(s):  
Prostaglandin E ◽  
Prostaglandin E Synthase ◽  
Microsomal Prostaglandin E Synthase

scholarly journals Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

2010 ◽  
Vol 285 (38) ◽  
pp. 29254-29261 ◽  
Author(s):  
Sven-Christian Pawelzik ◽  
Narasimha Rao Uda ◽  
Linda Spahiu ◽  
Caroline Jegerschöld ◽  
Patric Stenberg ◽  
...  
Keyword(s):  
Species Differences ◽  
Prostaglandin E ◽  
Inhibitor Binding ◽  
Prostaglandin E Synthase ◽  
Key Residues ◽  
Microsomal Prostaglandin E Synthase

scholarly journals Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors

2015 ◽  
Vol 59 (1) ◽  
pp. 194-205 ◽  
Author(s):  
Matthew A. Schiffler ◽  
Stephen Antonysamy ◽  
Shobha N. Bhattachar ◽  
Kristina M. Campanale ◽  
Srinivasan Chandrasekhar ◽  
...  
Keyword(s):  
Prostaglandin E ◽  
Prostaglandin E Synthase ◽  
Microsomal Prostaglandin E Synthase

scholarly journals Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

2017 ◽  
Vol 27 (6) ◽  
pp. 1478-1483 ◽  
Author(s):  
Katherine M. Partridge ◽  
Stephen Antonysamy ◽  
Shobha N. Bhattachar ◽  
Srinivasan Chandrasekhar ◽  
Matthew J. Fisher ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Prostaglandin E ◽  
Prostaglandin E Synthase ◽  
Microsomal Prostaglandin E Synthase

Purification and characterization of recombinant microsomal prostaglandin E synthase-1

2002 ◽  
Vol 26 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Marc Ouellet ◽  
Jean-Pierre Falgueyret ◽  
Po Hien Ear ◽  
Ally Pen ◽  
Joseph A Mancini ◽  
...  
Keyword(s):  
Prostaglandin E ◽  
Purification And Characterization ◽  
Prostaglandin E Synthase ◽  
Microsomal Prostaglandin E Synthase
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