Adenosine A2A receptor and vascular response: role of soluble epoxide hydrolase, adenosine A1 receptor and angiotensin-II

2021 ◽  
Author(s):  
Ahmad Hanif ◽  
Stephanie O. Agba ◽  
Catherine Ledent ◽  
Stephen L. Tilley ◽  
Christophe Morisseau ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Adenosine A2a Receptor ◽  
Vascular Response ◽  
A2a Receptor ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Adenosine A2a

scholarly journals Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase‐null mice through cyp2j‐epoxygenases and PPARγ

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Mohammed A Nayeem ◽  
Isha Pradhan ◽  
S Jamal Mustafa ◽  
Christophe Morisseau ◽  
John R Falck ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Adenosine A2a Receptor ◽  
Vascular Response ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Disruption of soluble epoxide hydrolase modulates adenosine‐induced response: role of adenosine A2A receptor and cyp‐epoxygenases

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Mohammed A. Nayeem ◽  
Darryl C. Zeldin ◽  
Isha Pradhan ◽  
S Jamal Mustafa ◽  
John R. Falck ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Adenosine A2a Receptor ◽  
Induced Response ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Adenosine A 2A Receptor and Vascular Response: Role of Soluble Epoxide Hydrolase, Adenosine A 1 Receptor and Angiotensin‐II

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Stephanie Agba ◽  
Ahmed Hanif ◽  
Catherine Ledent ◽  
Stephen Tilley ◽  
Christophe Morisseau ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Vascular Response

scholarly journals Die adenosien A1- en A2A-reseptoraffiniteit van ’n reeks 3,4-dihidropirimidoon-analoë

2017 ◽  
Vol 36 (1) ◽  
Author(s):  
Runako M. Katsidzira ◽  
Mietha M. Van der Walt ◽  
Jacobus J. Bergh ◽  
Gisella Terre’Blanche
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Adenosine A2a Receptor ◽  
Adenosine A1 Receptor ◽  
Receptor Affinity ◽  
A2a Receptors ◽  
A2a Receptor ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Adenosine A2a

Parkinson’s disease is a complex neurodegenerative condition with current treatment only focussed on symptomatic therapy that does not slow or stop the progression of the disease. Since the discovery that adenosine A1 and A2A receptors are potential drug targets for the therapy of Parkinson’s disease, various research groups have attempted to identify adenosine antagonists. So the possibility exists that the administration of an adenosine A2A receptor antagonist may prevent further neurodegeneration. Furthermore, the antagonism of adenosine A1 receptors has the potential of treating Parkinson’s disease-associated cognitive deficits. Therefore, dual antagonism of adenosine A1 and A2A receptors would be of great benefit since this would potentially treat both the motor as well as the cognitive impairment associated with Parkinson’s disease. Based on the observation that a series of 1,4-dihydropyridine derivatives possess adenosine A1 and A2A receptor affinity, the current study investigated the potential of the structurally related 3,4-dihydropyrimidone analogues as adenosine A1 and A2A receptor antagonists. Overall, the 3,4-dihyropyrimidone analogues were found to possess weak affinity for the adenosine A2A receptor, but more promising adenosine A1 receptor affinity was found, ranging in the low micromolar range. Among the investigated compounds, the p-bromophenyl substituted dihydropyrimidone (6b) possesses the best adenosine A1 receptor affinity with a Ki value of 7.39 µM. In conclusion, this 3,4-dihydropyrimidone derivative can be used as a lead for the design of novel adenosine A1 receptor antagonists, although further structural modifications are required to enhance the adenosine A2A receptor affinity before a clinically viable candidate will be available as potential treatment of Parkinson’s disease.

Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos

2003 ◽  
Vol 18 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Marzena Karcz-Kubicha ◽  
Davide Quarta ◽  
Bruce T. Hope ◽  
Katerina Antoniou ◽  
Christa. E. Muller ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Adenosine A1 Receptors ◽  
A2a Receptor ◽  
Adenosine A1 ◽  
Adenosine A2a

Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2a receptor signaling in the neostriatum

Neuroscience ◽  
2006 ◽  
Vol 141 (1) ◽  
pp. 19-25 ◽  
Author(s):  
K. Yabuuchi ◽  
M. Kuroiwa ◽  
T. Shuto ◽  
N. Sotogaku ◽  
G.L. Snyder ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Signaling ◽  
Adenosine A1 Receptors ◽  
A2a Receptor ◽  
Adenosine A1 ◽  
Adenosine A2a
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