Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors

2015 ◽  
Vol 124 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Hirokazu Takami ◽  
Shintaro Fukushima ◽  
Kohei Fukuoka ◽  
Tomonari Suzuki ◽  
Takaaki Yanagisawa ◽  
...  
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
Intracranial Germ Cell Tumors

scholarly journals Blood to cerebrospinal fluid human chorionic gonadotropin-beta ratios in intracranial germ cell tumors

1998 ◽  
Vol 5 (1) ◽  
pp. E6 ◽  
Author(s):  
Paul B. Rogers ◽  
Eliot C. Sims ◽  
Nicholas Plowman
Keyword(s):  
Cerebrospinal Fluid ◽  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
Intrathecal Administration ◽  
Pineal Region ◽  
Elevated Blood ◽  
Intracranial Germ Cell Tumors ◽  
Human Chorionic Gonadotropin Beta

Levels of human chorionic gonadotropin-beta (HCG-beta) are elevated in up to 43% of patients with intracranial germ cell tumors (GCTs) and are useful in the diagnosis of these tumors and the follow up of such patients. The ratio of blood HCG-beta to lumbar cerebrospinal fluid (CSF) HCG-beta in these patients at presentation has not been defined. Twenty-two patients with intracranial GCTs have been treated at St. Bartholomew's Hospital over the past 15 years. Two (17%) of 12 germinomas and seven (70%) of 10 nongerminomatous GCTs had elevated blood HCG-beta at presentation. Four cases of pineal region GCTs (one of 12 germinomas and three of 10 nongerminomatous GCTs) had paired, elevated, blood and lumbar CSF HCG-beta levels. The mean blood to CSF ratio was 1:10 (range 1.7-18.4), which is substantially lower than the ratio of 286:1 reported in systemic GCTs. The authors confirm the finding of a previous single report showing that ventricular CSF HCG-beta sampling via an accessible ventriculoperitoneal shunt reservoir may give a spuriously negative result, and they discuss the pathophysiology of the blood-brain barrier in the pineal region and the implications of the intrathecal administration of chemotherapy.

Serum and Cerebrospinal Fluid Human Chorionic Gonadotropin (hCG) and alpha-fetoprotein (AFP) in Intracranial Germ Cell Tumors

2002 ◽  
Vol 17 (2) ◽  
pp. 112-118 ◽  
Author(s):  
E. Seregni ◽  
M. Massimino ◽  
S. Nerini Molteni ◽  
F. Pallotti ◽  
B. van der Hiel ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
High Serum ◽  
Response To Therapy ◽  
Alpha Fetoprotein ◽  
Intracranial Germ Cell Tumors

We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) and β-human chorionic gonadotropin (βhCG) determination in a series of 30 patients bearing intracranial germ cell tumors. At diagnosis five patients had high serum and CSF AFP levels. No patient had positive serum AFP and negative CSF AFP or vice versa. Twelve of 30 patients had serum βhCG levels above 5 mIU/mL, eight had high βhCG only in CSF, and ten were completely negative. During treatment and follow-up both markers were accurate indicators of the response to therapy, decreasing rapidly and often becoming normal already after the first phase of treatment. We conclude that these two markers, and mostly βhCG, may be useful in the diagnosis and monitoring of the response to therapy of patients with intracranial germ cell tumors.

Intracranial germ-cell tumors

1984 ◽  
Vol 61 (5) ◽  
pp. 931-937 ◽  
Author(s):  
Hirofumi Naganuma ◽  
Hiroshi Inoue ◽  
Shuzo Misumi ◽  
Masaru Nakamura ◽  
Masaru Tamura
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Embryonal Carcinoma ◽  
Germ Cell Tumors ◽  
Endodermal Sinus Tumor ◽  
Content Type ◽  
First Case ◽  
Intracranial Germ Cell Tumors ◽  
Sinus Tumor

✓ Histological and immunohistochemical findings in three cases with primary intracranial germ-cell tumors are reported. Based on histological examination, they were diagnosed, respectively, as an endodermal sinus tumor with immature teratoid differentiation, teratoma and embryonal carcinoma, and choriocarcinoma and germinoma. The first case was presumed to be a combination of endodermal sinus tumor and germinoma. An immunohistochemical examination showed positive reactions to alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in the endodermal sinus tumor, and to human chorionic gonadotropin (HCG) in the choriocarcinoma, but showed no reaction in the embryonal carcinoma. Human chorionic gonadotropin was demonstrated in syncytiotrophoblastic cells and CEA in a gland-like structure. The value of measuring CEA in cases of germ-cell tumors, in addition to AFP and HCG assays, is stressed, and the characteristics of CEA-positive tissue are discussed.

Hyperthyroidism in men with germ cell tumors and high levels of beta-human chorionic gonadotropin

Cancer ◽  
2010 ◽  
Vol 69 (5) ◽  
pp. 1286-1290 ◽  
Author(s):  
Sergio A. Giralt ◽  
Francisco Dexeus ◽  
Robert Amato ◽  
Avishay Sella ◽  
Christopher Logothetis
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
Beta Human Chorionic Gonadotropin

Evaluation of neoadjuvant therapy in patients with nongerminomatous malignant germ cell tumors

2011 ◽  
Vol 7 (4) ◽  
pp. 431-438 ◽  
Author(s):  
Hideo Nakamura ◽  
Keishi Makino ◽  
Masato Kochi ◽  
Yukitaka Ushio ◽  
Jun-ichi Kuratsu
Keyword(s):  
Germ Cell ◽  
Neoadjuvant Therapy ◽  
Tumor Markers ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Tumor Recurrence ◽  
Germ Cell Tumors ◽  
Residual Tumor ◽  
The Other ◽  
Malignant Germ Cell Tumors

Object The authors evaluated the effectiveness of a neoadjuvant therapy (NAT) consisting of combined chemoand radiotherapy followed by complete resection of the residual tumor in patients with nongerminomatous malignant germ cell tumors (NGMGCTs). Methods The authors treated 14 consecutive patients in whom NGMGCTs were diagnosed based on elevated levels of the tumor markers α-fetoprotein, human chorionic gonadotropin, and the β-subunit of human chorionic gonadotropin (β-HCG). Chemotherapy and radiotherapy were performed, and after the serum tumor markers level was in the normal or near-normal range, the residual tumors were completely resected. Results Residual tumors were confirmed in 11 of the 14 patients after NAT, and total removal was successful in 10 of the 11 patients. In the other patient the residual tumor could not be completely excised because it was attached to a deep vein. The follow-up duration ranged from 1.2 to 22.2 years. The 5-year event-free and total survival rates were 86% and 93%, respectively. Although 3 patients died, 2 of tumor recurrence and 1 of a radiation-induced secondary tumor (glioblastoma), the other 11 are alive and without evidence of tumor recurrence. Conclusions The authors consider their NAT protocol for NGMGCT to be highly effective in relation to survival for the patients with NGMGCT, but there are several quality of life issues that need to be resolved.

Sign in / Sign up

Export Citation Format

Share Document