Joint modelling with competing risks of dropout for longitudinal analysis of health-related quality of life in cancer clinical trials

2021 ◽  
Author(s):  
Benjamin Cuer ◽  
Thierry Conroy ◽  
Beata Juzyna ◽  
Sophie Gourgou ◽  
Caroline Mollevi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Competing Risks ◽  
Longitudinal Analysis ◽  
Cancer Clinical Trials ◽  
Health Related Quality ◽  
Joint Modelling ◽  
Related Quality ◽  
Health Related

International Perspective on Health-Related Quality-of-Life Research in Cancer Clinical Trials: The European Organisation for Research and Treatment of Cancer Experience

2007 ◽  
Vol 25 (32) ◽  
pp. 5082-5086 ◽  
Author(s):  
Andrew Bottomley ◽  
Neil K. Aaronson
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Clinical Trials ◽  
Phase Iii ◽  
Cancer Clinical Trials ◽  
Health Related Quality ◽  
European Organisation ◽  
Related Quality ◽  
Health Related

Over recent decades, health-related quality of life (HRQOL) research has been increasingly integrated into cancer clinical trials. The purpose of this review is to examine the overall approach taken towards clinical trial–based HRQOL investigations within the European Organisation for Research and Treatment of Cancer (EORTC). This article reports a literature review of clinical trial–based HRQOL investigations and provides selective examples of HRQOL studies in phase III clinical trials in various disease sites. The findings of this review highlight that, historically, assessing HRQOL was a challenge. However, as EORTC has become more experienced in the assessment of HRQOL and has developed a portfolio of appropriate tools, HRQOL has become a more accepted end point in large-scale trials. The trials reviewed in this article show that, in general, HRQOL data do provide information that can both inform clinicians about the effectiveness of the treatments and also serve as an invaluable source of information for patients to make informed decisions regarding the treatment choice.

Health related quality of life outcomes in cancer clinical trials

2005 ◽  
Vol 41 (12) ◽  
pp. 1697-1709 ◽  
Author(s):  
A. Bottomley ◽  
H. Flechtner ◽  
F. Efficace ◽  
V. Vanvoorden ◽  
C. Coens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Cancer Clinical Trials ◽  
Health Related Quality ◽  
Life Outcomes ◽  
Quality Of Life Outcomes ◽  
Related Quality ◽  
Health Related

Statistical Challenges in the Analysis of Health-Related Quality of Life in Cancer Clinical Trials

2016 ◽  
Vol 34 (16) ◽  
pp. 1953-1956 ◽  
Author(s):  
Franck Bonnetain ◽  
Frédéric Fiteni ◽  
Fabio Efficace ◽  
Amélie Anota
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Cancer Clinical Trials ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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