In this paper we consider a class of infinite systems of linear ODEs. Each system corresponds to a process characterized by two components: the conservative one (birth-and-death process) and the proliferative one. A system of this type can describe the population of neoplastic cells divided into subpopulations characterized by different levels of cellular resistance to antineoplastic drugs. Under suitable assumptions on the "birth" (amplification) coefficients, the "death" (deamplification) coefficients and the averages of the life-spans we prove that this class of models is topologically chaotic.