Low Dose Intratympanic Gentamicin in Ménière’s Disease

2020 ◽  
Author(s):  
Bini Faizal ◽  
Afsha Rajan
Keyword(s):  
Low Dose ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Intratympanic Gentamicin ◽  
Ménière's Disease

Is low-dose intratympanic gentamicin an effective treatment for Ménière's disease: the Birmingham experience

2015 ◽  
Vol 129 (10) ◽  
pp. 970-973 ◽  
Author(s):  
G J Watson ◽  
C Nelson ◽  
R M Irving
Keyword(s):  
Low Dose ◽  
Symptom Control ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Intratympanic Gentamicin ◽  
Ménière's Disease ◽  
Gentamicin Therapy

AbstractBackground:Since the development of intratympanic aminoglycoside in the 1950s, otologists have been able to chemically ablate the vestibule. We present the results of using low-dose intratympanic gentamicin to treat Ménière's disease.Method:A retrospective review was performed of all patients who underwent low-dose intratympanic gentamicin therapy over seven years. Data on gender, age, number of procedures, pure tone audiometry and symptom control were analysed.Results:In all, 38 patients underwent low-dose intratympanic gentamicin therapy. These comprised 25 females and 13 males, with an average age of 58.4 years. Hearing was preserved in 87.5 per cent of patients, with no significant difference before and after treatment (p = 0.744). In all, 85.7 per cent of patients had complete or substantial symptom control (classes A and B, respectively).Conclusion:Low-dose intratympanic gentamicin therapy was effective in controlling the symptoms of Ménière's disease patients, while preserving hearing.

Low-Dose Intratympanic Gentamicin and the Treatment of Meniere's Disease: Preliminary Results

1997 ◽  
Vol 107 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Colin L. W. Driscoll ◽  
Jan L. Kasperbauer ◽  
George W. Facer ◽  
Stephen G. Harner ◽  
Charles W. Beatty
Keyword(s):  
Low Dose ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Preliminary Results ◽  
Intratympanic Gentamicin ◽  
Ménière's Disease

Vestibular function at the end of intratympanic gentamicin treatment of patients with Ménière's disease

2005 ◽  
Vol 15 (1) ◽  
pp. 49-58
Author(s):  
Nicolas Perez ◽  
Julio Rama-Lopez
Keyword(s):  
Time Constant ◽  
Vestibular Function ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Bedside Examination ◽  
Intratympanic Gentamicin ◽  
Ménière's Disease

The aim of this study is to analyze the effects of intratympanic gentamicin injections on vestibular function in 33 patients with unilateral Meniere's Disease (according to AAO-HNS guidelines 1995) that had been unresponsive to medical therapy for at least one year. In such patients, the results of bedside examination of vestibular function vestibular examination is compared to those from laboratory tests. Intratympanic gentamicin injections (27 mg/ml) were performed at weekly intervals until symptoms or signs of vestibular hypofunction developed in the treated ear. Vestibular function was evaluated in two different rotatory chair tests. The parameters that were specifically considered were the time constant of the vestibulo-ocular reflex (VOR) after impulse rotation with a peak chair velocity of 100°s-1, and the phase and gain of the VOR after the sinusoidal harmonic acceleration (SHA) test with a peak chair velocity of 50°s-1. After treatment, both the time constant of the VOR after rotation towards the treated side and the gain in the SHA test were significantly reduced. These reductions were in accordance with the number of additional signs observed upon bedside examination at the end of the treatment. The changes observed in the VOR correlate well with the results of bedside examination of vestibular function, which in turn reflects the damage induced by intratympanic gentamicin injection.

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