scholarly journals Last issue of journal of chemical biology

2017 ◽  
Vol 10 (4) ◽  
pp. 157-157
Author(s):  
Rudiger Woscholski ◽  
Banafshe Larijani
Keyword(s):  
Chemical Biology

Correction: Graduate Education in Chemical Biology at the University of Michigan

2006 ◽  
Vol 1 (9) ◽  
pp. 601
Author(s):  
Tonia J. Buchholz ◽  
Bruce Palfey ◽  
Anna K. Mapp ◽  
Gary D. Glick
Keyword(s):  
Graduate Education ◽  
Chemical Biology ◽  
University Of Michigan ◽  
The University

Chemical biology: A natural painkiller

Nature China ◽  
2014 ◽  
Author(s):  
Felix Cheung
Keyword(s):  
Chemical Biology

Chemical biology: On neutral ground

Nature China ◽  
2009 ◽  
Author(s):  
Felix Cheung
Keyword(s):  
Chemical Biology ◽  
Neutral Ground

Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination

2020 ◽  
Author(s):  
Bapurao Bhoge ◽  
Ishu Saraogi
Keyword(s):  
Organic Chemistry ◽  
Chemical Biology ◽  
Reductive Amination ◽  
The Other ◽  
Dna Oligomers ◽  
Site Specific ◽  
Wide Applicability ◽  
Dna Oligonucleotides ◽  
Selective Functionalization

Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N<sup>2</sup>-amine of guanine/2’-deoxyguanine monophosphate. This method specifically modifies guanine in several tested DNA oligonucleotides, while leaving the other bases unaffected. Using this approach, we have successfully incorporated desired handles chemoselectively into DNA oligomers.

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