scholarly journals Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants

2021 ◽  
Author(s):  
Jiawen Yang ◽  
Wenjin Zhao ◽  
Yu Li
Keyword(s):  
Health Risk ◽  
Human Health ◽  
Endocrine Disruption ◽  
Flame Retardants ◽  
Human Health Risk ◽  
Reproductive Toxicity ◽  
Special Populations ◽  
Risk Regulation ◽  
Organophosphorus Flame Retardants

scholarly journals Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants

2021 ◽  
Author(s):  
Jiawen Yang ◽  
Wenjin Zhao ◽  
Yu Li
Keyword(s):  
Health Risk ◽  
Pregnant Women ◽  
Endocrine Disruption ◽  
Density Functional ◽  
Flame Retardants ◽  
Human Health Risk ◽  
Reproductive Toxicity ◽  
Joint Toxicity ◽  
Risk Regulation ◽  
Organophosphorus Flame Retardants

Abstract In this study, the joint toxicological characteristics of reproductive toxicity, neurotoxicity, and endocrine disruption (ED) by organophosphorus flame retardants (OPFRs) were regulated by process control. Molecular docking technology, molecular dynamics (MD), 2D-QSAR model, and density functional theory (DFT) were used to develop a health risk regulation scheme for special population such as pregnant women exposed to OPFRs. It was found that MD simulations confirmed the effectiveness of the recommended complementary food scheme (CFS) for the pregnant women with low health risk. When β-lactoglobulin, α-lactoalbumin, milk fat globule membrane (MFGM) protein, ovalbumin (OVA), ovotransferrin (OVT), vitamin, plant pigment, apple polyphenols, and malic acid were present in the CFS, the joint toxicity of OPFRs in pregnant women were significantly decreased by 91.18%. The reproductive toxicity played a dominant role in the joint toxicity and could be reduced by 82.48% under the recommended CFS. There was a competitive relationship between the nutrients in the recommended CFS and OPFRs binding to the joint toxic receptor (JTR). The former could easily occupy the target binding spot of the JTR protein, which reduced or prevented the binding of OPFRs to the JTR. In addition, simulation of OPFRs molecular metabolic pathways in pregnant women under the recommended CFS showed that the binding affinity between OPFRs and six metabolic kinases in pregnant women was significantly decreased (–28.85% -–87.54%), indicating that the inhibition effect of OPFRs on normal biochemical reactions in the human body was significantly reduced, which to a certain extent verified the effectiveness of the recommended CFS.

Organophosphorus flame retardants in the European eel in Flanders, Belgium: Occurrence, fate and human health risk

2015 ◽  
Vol 140 ◽  
pp. 604-610 ◽  
Author(s):  
Govindan Malarvannan ◽  
Claude Belpaire ◽  
Caroline Geeraerts ◽  
Igor Eulaers ◽  
Hugo Neels ◽  
...  
Keyword(s):  
Health Risk ◽  
Human Health ◽  
Flame Retardants ◽  
Human Health Risk ◽  
European Eel ◽  
Organophosphorus Flame Retardants

Human health risk associated with brominated flame-retardants (BFRs)

2015 ◽  
Vol 74 ◽  
pp. 170-180 ◽  
Author(s):  
Jan L. Lyche ◽  
Carola Rosseland ◽  
Gunnar Berge ◽  
Anuschka Polder
Keyword(s):  
Health Risk ◽  
Human Health ◽  
Flame Retardants ◽  
Human Health Risk ◽  
Brominated Flame Retardants

Human health risk assessment: application of the NORISC-HRA and ROME models at two test sites

2006 ◽  
Vol 14 (2) ◽  
pp. 559-570 ◽  
Author(s):  
F. Quercia ◽  
A. Vecchio ◽  
M. Falconi ◽  
L. Togni ◽  
E. Wcislo ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
Human Health Risk ◽  
Human Health Risk Assessment
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