Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model

2012 ◽  
Vol 69 (3) ◽  
pp. 349-357 ◽  
Author(s):  
Shaofeng Pu ◽  
Yongming Xu ◽  
Dongping Du ◽  
Meirong Yang ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nmda Receptor ◽  
Mechanical Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model

Rufinamide alleviates mechanical allodynia in a mouse neuropathic pain model

2011 ◽  
Vol 28 ◽  
pp. 193
Author(s):  
M. R. Suter ◽  
G. Kirschmann ◽  
H. Abriel ◽  
I. Decosterd
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals Mechanical Allodynia Assessment in a Murine Neuropathic Pain Model

BIO-PROTOCOL ◽  
2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Serena Notartomaso ◽  
Pamela Scarselli ◽  
Paola Di Pietro ◽  
Giuseppe Battaglia ◽  
Amadeu Llebaria ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model

Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model

Pain ◽  
2004 ◽  
Vol 110 (1) ◽  
pp. 56-63 ◽  
Author(s):  
James J Lynch ◽  
Carrie L Wade ◽  
Chengmin M Zhong ◽  
Joseph P Mikusa ◽  
Prisca Honore
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model

Effects of site-directed GDNF overexpression on mechanical allodynia in a neuropathic pain model

2009 ◽  
Vol 65 ◽  
pp. S180
Author(s):  
Atsushi Sakai ◽  
Hideki Hanawa ◽  
Takashi Shimada ◽  
Hidenori Suzuki
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model

Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain

2019 ◽  
Vol 44 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Jeffrey S Kroin ◽  
Vaskar Das ◽  
Mario Moric ◽  
Asokumar Buvanendran
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Postoperative Pain ◽  
Mechanical Allodynia ◽  
Pain Syndrome ◽  
Saline Control ◽  
Pain Model ◽  
Time Period ◽  
Pain Models ◽  
Neuropathic Pain Model

Background and objectivesKetamine has been shown to reduce chronic pain; however, the adverse events associated with ketamine makes it challenging for use outside of the perioperative setting. The ketamine metabolite (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) has a therapeutic effect in mice models of depression, with minimal side effects. The objective of this study is to determine if (2R,6R)-HNK has efficacy in both acute and chronic mouse pain models.MethodsMice were tested in three pain models: nerve-injury neuropathic pain, tibia fracture complex regional pain syndrome type-1 (CRPS1) pain, and plantar incision postoperative pain. Once mechanical allodynia had developed, systemic (2R,6R)-HNK or ketamine was administered as a bolus injection and compared with saline control in relieving allodynia.ResultsIn all three models, 10 mg/kg ketamine failed to produce sustained analgesia. In the neuropathic pain model, a single intraperitoneal injection of 10 mg/kg (2R,6R)-HNK elevated von Frey thresholds over a time period of 1–24hours compared with saline (F=121.6, p<0.0001), and three daily (2R,6R)-HNK injections elevated von Frey thresholds for 3 days compared with saline (F=33.4, p=0.0002). In the CRPS1 model, three (2R,6R)-HNK injections elevated von Frey thresholds for 3 days and then an additional 4 days compared with saline (F=116.1, p<0.0001). In the postoperative pain model, three (2R,6R)-HNK injections elevated von Frey thresholds for 3 days and then an additional 5 days compared with saline (F=60.6, p<0.0001).ConclusionsThis study demonstrates that (2R,6R)-HNK is superior to ketamine in reducing mechanical allodynia in acute and chronic pain models and suggests it may be a new non-opioid drug for future therapeutic studies.

scholarly journals Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60733 ◽  
Author(s):  
Xi-Tuan Ji ◽  
Nian-Song Qian ◽  
Tao Zhang ◽  
Jin-Mao Li ◽  
Xin-Kui Li ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model
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