Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor

Jeanne Mendell; Hamim Zahir; Nobuko Matsushima; Robert Noveck; Frank Lee; Shuquan Chen; George Zhang; Minggao Shi

doi:10.1007/s40256-013-0029-0

Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor

American Journal of Cardiovascular Drugs ◽

10.1007/s40256-013-0029-0 ◽

2013 ◽

Vol 13 (5) ◽

pp. 331-342 ◽

Cited By ~ 122

Author(s):

Jeanne Mendell ◽

Hamim Zahir ◽

Nobuko Matsushima ◽

Robert Noveck ◽

Frank Lee ◽

...

Keyword(s):

Drug Interaction ◽

Factor Xa ◽

Cardiovascular Drugs ◽

Factor Xa Inhibitor ◽

Efflux Transporter ◽

P Glycoprotein ◽

Interaction Studies ◽

Drug Drug Interaction

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DRUG-DRUG INTERACTION STUDIES OF CARDIOVASCULAR DRUGS (AMIODARONE, DIGOXIN, QUINIDINE, ATORVASTATIN AND VERAPAMIL) INVOLVING P-GLYCOPROTEIN (P-GP), AN EFFLUX TRANSPORTER, ON THE PHARMACOKINETICS (PK) AND PHARMACODYNAMICS (PD) OF EDOXABAN, AN ORAL FACTOR XA INHIBITOR

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(11)61510-6 ◽

2011 ◽

Vol 57 (14) ◽

pp. E1510 ◽

Cited By ~ 6

Author(s):

Jeanne Mendell ◽

Halim Zahir ◽

Graham Ridout ◽

Robert Noveck ◽

Frank Lee ◽

...

Keyword(s):

Drug Interaction ◽

Factor Xa ◽

Cardiovascular Drugs ◽

Factor Xa Inhibitor ◽

Efflux Transporter ◽

Glycoprotein P ◽

P Glycoprotein ◽

Interaction Studies ◽

Drug Drug Interaction

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Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug–Drug Interaction Studies

Clinical Pharmacokinetics ◽

10.1007/s40262-020-00867-1 ◽

2020 ◽

Vol 59 (6) ◽

pp. 699-714 ◽

Cited By ~ 11

Author(s):

Mohamed Elmeliegy ◽

Manoli Vourvahis ◽

Cen Guo ◽

Diane D. Wang

Keyword(s):

Drug Interaction ◽

Glycoprotein P ◽

P Glycoprotein ◽

Interaction Studies ◽

Drug Drug Interaction ◽

Clinical Drug

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Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects

Clinical Drug Investigation ◽

10.1007/s40261-020-00902-w ◽

2020 ◽

Vol 40 (6) ◽

pp. 529-540

Author(s):

Kazuya Fukumura ◽

Nao Kawaguchi ◽

Toru Ishibashi ◽

Ryuji Kubota ◽

Yukio Tada ◽

...

Keyword(s):

Drug Interaction ◽

Healthy Subjects ◽

P Glycoprotein ◽

Interaction Studies ◽

Drug Drug Interaction ◽

Clinical Drug

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Faculty Opinions recommendation of Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718043074.793480891 ◽

2013 ◽

Author(s):

Bruno Stieger

Keyword(s):

Risk Assessment ◽

Drug Interaction ◽

Decision Criteria ◽

Inhibitory Potency ◽

Experimental Systems ◽

P Glycoprotein ◽

Drug Drug Interaction

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Lurasidone drug-drug interaction studies: a comprehensive review

Drug Metabolism and Drug Interactions ◽

10.1515/dmdi-2014-0005 ◽

2014 ◽

Vol 29 (3) ◽

Cited By ~ 14

Author(s):

Yu-Yuan Chiu ◽

Larry Ereshefsky ◽

Sheldon H. Preskorn ◽

Nagaraju Poola ◽

Antony Loebel

Keyword(s):

Drug Interaction ◽

Comprehensive Review ◽

Interaction Studies ◽

Drug Drug Interaction

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Is It Time to Use Modeling of Cellular Transporter Homeostasis to Inform Drug-Drug Interaction Studies: Theoretical Considerations

The AAPS Journal ◽

10.1208/s12248-021-00635-4 ◽

2021 ◽

Vol 23 (5) ◽

Author(s):

Roberto A. Abbiati ◽

M. Guillaume Wientjes ◽

Jessie L.-S. Au

Keyword(s):

Drug Interaction ◽

Interaction Studies ◽

Drug Drug Interaction ◽

Theoretical Considerations

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Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Ana

The Journal of Clinical Pharmacology ◽

10.1002/jcph.988 ◽

2017 ◽

Vol 58 (2) ◽

pp. 180-192 ◽

Cited By ~ 20

Author(s):

Neeraj Gupta ◽

Michael J. Hanley ◽

Karthik Venkatakrishnan ◽

Alberto Bessudo ◽

Drew W. Rasco ◽

...

Keyword(s):

Drug Interaction ◽

Solid Tumors ◽

Proteasome Inhibitor ◽

Advanced Solid Tumors ◽

Physiologically Based Pharmacokinetic ◽

Interaction Studies ◽

Physiologically Based ◽

Drug Drug Interaction

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