A Pharmacological Batch of Mongersen that Downregulates Smad7 is Effective as Induction Therapy in Active Crohn’s Disease: A Phase II, Open-Label Study

Irene Marafini; Carmine Stolfi; Edoardo Troncone; Elisabetta Lolli; Sara Onali; Omero Alessandro Paoluzi; Massimo C. Fantini; Livia Biancone; Emma Calabrese; Antonio Di Grazia; Ivan Monteleone; Marco Vincenzo Lenti; Antonio Di Sabatino; Giovanni Monteleone

doi:10.1007/s40259-021-00482-x

A Pharmacological Batch of Mongersen that Downregulates Smad7 is Effective as Induction Therapy in Active Crohn’s Disease: A Phase II, Open-Label Study

BioDrugs ◽

10.1007/s40259-021-00482-x ◽

2021 ◽

Vol 35 (3) ◽

pp. 325-336

Author(s):

Irene Marafini ◽

Carmine Stolfi ◽

Edoardo Troncone ◽

Elisabetta Lolli ◽

Sara Onali ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Phase Ii ◽

Induction Therapy ◽

Open Label ◽

Open Label Study ◽

Label Study

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Adalimumab maintenance therapy for Crohn’s disease with intolerance or lost response to infliximab: an open-label study

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2007.03254.x ◽

2007 ◽

Vol 25 (6) ◽

pp. 675-680 ◽

Cited By ~ 46

Author(s):

L. PEYRIN-BIROULET ◽

C. LACLOTTE ◽

M.-A. BIGARD

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Maintenance Therapy ◽

Open Label ◽

Open Label Study ◽

Label Study

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Mo1268 The Investigation of the Factors for Confirming the Patency by Novel Tag-Less Agile Patency Capsule-J for Patients With Crohn's Disease and the Other Intestinal Diseases, Prospective, Open-Label Study

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2012.03.974 ◽

2012 ◽

Vol 75 (4) ◽

pp. AB371 ◽

Cited By ~ 2

Author(s):

Kenji Watanabe ◽

Naoki Ohmiya ◽

Masanao Nakamura ◽

Yasuhiro Fujiwara ◽

Hidemi Goto ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

The Other ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Intestinal Diseases ◽

Patency Capsule

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A phase IIa, open label study of visilizumab for the treatment of perianal fistulas in patients with Crohn's disease

http://isrctn.org/> ◽

10.1186/isrctn65243779 ◽

2012 ◽

Author(s):

Daniel Hommes

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Perianal Fistulas

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P157 The clinical efficacy of novel tag-less Agile Patency Capsule (Agile-J) for Crohn's disease patients with suspected or known intestinal stricture prior to capsule endoscopy procedure a prospective open-label study

Journal of Crohn s and Colitis ◽

10.1016/s1873-9946(12)60177-9 ◽

2012 ◽

Vol 6 ◽

pp. S72

Author(s):

K. Watanabe ◽

K. Morimoto ◽

N. Ohmiya ◽

M. Nakamura ◽

H. Goto ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Clinical Efficacy ◽

Capsule Endoscopy ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Patency Capsule ◽

Intestinal Stricture

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Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/00005176-200010000-00024 ◽

2000 ◽

Vol 31 (4) ◽

pp. 453-457 ◽

Cited By ~ 251

Author(s):

Puneet Gupta ◽

Haikaeli Andrew ◽

Barbara S. Kirschner ◽

Stefano Guandalini

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Lactobacillus Gg

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An Open-Label Study of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Prior Loss of Response or Intolerance to Infliximab for Crohn's Disease

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2004.40462.x ◽

2004 ◽

Vol 99 (10) ◽

pp. 1984-1989 ◽

Cited By ~ 181

Author(s):

William J. Sandborn ◽

Stephen Hanauer ◽

Edward V. Loftus ◽

William J. Tremaine ◽

Sunanda Kane ◽

...

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Loss Of Response

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P441 Thalidomide induces clinical remission and mucosal healing in adults with active Crohn's disease: a prospective open-label study

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjx002.566 ◽

2017 ◽

Vol 11 (suppl_1) ◽

pp. S300-S301

Author(s):

R. Mao ◽

Y. He ◽

S. Ben-Horin ◽

M.-h. Chen

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Clinical Remission ◽

Mucosal Healing ◽

Open Label ◽

Open Label Study ◽

Label Study

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An open-label study of thalidomide for maintenance therapy in responders to infliximab in chronically active and fistulizing refractory Crohn's disease

Alimentary Pharmacology & Therapeutics ◽

10.1046/j.1365-2036.2002.01273.x ◽

2002 ◽

Vol 16 (6) ◽

pp. 1117-1124 ◽

Cited By ~ 51

Author(s):

J. M. Sabate ◽

J. Villarejo ◽

M. Lemann ◽

J. Bonnet ◽

M. Allez ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Maintenance Therapy ◽

Open Label ◽

Open Label Study ◽

Label Study

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Faculty of 1000 evaluation for Survival data from a phase II, open-label study of pazopanib or lapatinib monotherapy in patients with advanced and recurrent cervical cancer.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.717998895.793474496 ◽

2013 ◽

Author(s):

David Kushner

Keyword(s):

Cervical Cancer ◽

Phase Ii ◽

Survival Data ◽

Open Label ◽

Recurrent Cervical Cancer ◽

Open Label Study ◽

Label Study

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FIR: Efficacy, Safety, and Biomarker Analysis of a Phase II Open-Label Study of Atezolizumab in PD-L1–Selected Patients With NSCLC

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.05.004 ◽

2018 ◽

Vol 13 (11) ◽

pp. 1733-1742 ◽

Cited By ~ 39

Author(s):

David R. Spigel ◽

Jamie E. Chaft ◽

Scott Gettinger ◽

Bo H. Chao ◽

Luc Dirix ◽

...

Keyword(s):

Phase Ii ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Biomarker Analysis

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