Cervical Cancer
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2021 ◽  
Vol 153 ◽  
pp. 106831
Céline Audiger ◽  
Thomas Bovagnet ◽  
Michel Deghaye ◽  
Aldis Kaufmanis ◽  
Caroline Pelisson ◽  

2021 ◽  
Vol 15 (6) ◽  
Zhiyuan Xu ◽  
Li Yang ◽  
Lingyu Ma ◽  
Qin Liu ◽  
Amy Chang ◽  

2021 ◽  
Bernardo Vega ◽  
Vivian Alejandra Neira ◽  
José Ortíz ◽  
Ruth Maldonado – Rengel ◽  
Diana López ◽  

Abstract Background: Cervical cancer screening has demonstrated high effectiveness reducing cervical cancer mortality worldwide, however there is still a high rate of under screened women. Pap smear technique is often considered an uncomfortable examination technique that can reduce uptake of the examination. This study explores the perceptions of self sampling and urine sampling versus traditional pap smear in rural settings of Cuenca Ecuador.Methods A qualitative study with a phenomenological approach was performed. Focus groups were conducted in El Valle parish of Azuay province of Cuenca Ecuador. Women natives of this rural area were included in this research. Results A total of 45 women, have participated in 7 focus groups, all participants live in rural area. Pap smear technique is considered a painful, intrusive and embarrassing method, however participants believe that is more reliable, compared with self sampling methods, due a direct visualization of the cervix and because other problems could be detected during the examination. Advantages of self-sampling include that it is perceived as comfortable, less painful, participation rate, time-saving, because it can be done at home, and can be made widely available for example through pharmacies or with help of traditional healers . Barriers are related with doubts of the quality of the sample and lack of capability to perform it. Conclusions This study shows that women consider self sampling methods as a possible solution to overcome barriers that could reduce the uptake of cervical cancer screening; privacy, comfortability and accessibility are major advantages of those methods. Self examination at home reduces waiting times in health centers, with high demand of attention or during Covid pandemic. Barriers are mainly related with doubts in the self proficiency to perform the test and the accuracy of the results. Those doubts are understandable, because self sampling methods are never used before in Ecuador, and could be solved with an adequate training and information for the patients. Further studies that measure acceptability and sensitivity in real application are required to address the utility of self sampling methods in a rural context.

2021 ◽  
Vol 4 (10) ◽  
pp. e2128806
Ana Patricia Ortiz ◽  
Axel Gierbolini-Bermúdez ◽  
Jeslie M. Ramos-Cartagena ◽  
Vivian Colón-López ◽  
Kalyani Sonawane ◽  

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Guokun Liu ◽  
Xuan Du ◽  
Li Xiao ◽  
Qing Zeng ◽  
QianLing Liu

Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator in malignancies. Up to now, the detailed function of FGD5-AS1 in cervical cancer and its underlying molecular mechanisms remain uninvestigated. Bone marrow stromal cell antigen 2 (BST2) can play critical roles in immune response, and the roles of BST2 in cervical cancer was explored currently. The level of FGD5-AS1 and BST2 was detected by qRT-PCR in cervical cancer cells. FGD5-AS1 and BST2 expression was significantly upregulated in cervical cancer cells. Then, the decrease of FGD5-AS1 greatly repressed cervical cancer cell growth in vitro. In addition, FGD5-AS1 silencing repressed BST2 expression and suppressed M2 macrophage polarization. Mechanistically, we confirmed that FGD5-AS1 sponged miR-129-5p to reduce its inhibition on BST2. Furthermore, lack of BST2 depressed cervical cancer cell growth, while inducing apoptosis. Loss of BST2 induced M1 macrophage polarization while blocking M2 macrophage polarization. For another, we demonstrated that FGD5-AS1-triggered M2 macrophage polarization was remarkably reversed by miR-129-5p via suppressing BST2. In conclusion, FGD5-AS1 induced M2 macrophage polarization via sponging miR-129-5p and modulating BST2, thus contributing to cervical cancer development. Our findings revealed FGD5-AS1/miR-129-5p/BST2 as a new potential target for cervical cancer.

Chelsea Salyer ◽  
Jaehoon Lee ◽  
Jennifer Lorvick ◽  
Megan Comfort ◽  
Karen Cropsey ◽  

2021 ◽  
Dimitra Charatsi ◽  
Polyxeni Vanakara ◽  
Michail Nikolaou ◽  
Aikaterini Evaggelopoulou ◽  
Dimitrios Korfias ◽  

Background: Since continuing advances in radiotherapy technology broaden the role of radiotherapy in the treatment of gynaecologic malignancies, the use of vaginal dilators has been introduced in order to mitigate the risk of vaginal stenosis. The main aims of this study were to investigate the vaginal dilator use efficacy in the treatment of radiation-induced vaginal stenosis and the vaginal dilator effect on sexual quality of life. Methods: We studied fifty-three patients with endometrial or cervical cancer. The participants were treated with radical or adjuvant external beam radiotherapy and/or brachytherapy. They were routinely examined at four time points post-radiotherapy when also they were asked to fill in a validated sexual function-vaginal changes questionnaire. A p-value less than 0.05 was considered statistically significant. Results: The vaginal stenosis grading score was decreased and the size of the vaginal dilator comfortably insertable was gradually increased throughout the year of vaginal dilator use while radiation-induced vaginal and sexual symptoms were improved throughout the year of VD use. All patients with initial grade 3 showed vaginal stenosis of grade 2 after 12 months of vaginal dilator use and 65.8% of the patients with grade 2 initial vaginal stenosis demonstrated final vaginal stenosis grade 1 while 77.8% of the participants with initial 1st size of vaginal dilators reached the 3rd vaginal dilator size after 12 months. Starting time of dilator therapy <= 3 months after the end of radiotherapy was associated with a significant decrease in vaginal stenosis. Additionally, there was an overall upward trend regarding patients’ satisfaction with their sexual life. Conclusion: Endometrial and cervical cancer survivors should be encouraged to use vaginal dilators for the treatment of vaginal stenosis and sexual rehabilitation after radiotherapy.

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258599
Elnaz Abbasifarid ◽  
Azam Bolhassani ◽  
Shiva Irani ◽  
Fattah Sotoodehnejadnematalahi

Cervical cancer is the most common malignant tumor in females worldwide. Human papillomavirus (HPV) infection is associated with the occurrence of cervical cancer. Thus, developing an effective and low-cost vaccine against HPV infection, especially in developing countries is an important issue. In this study, a novel HPV L1-E7 fusion multiepitope construct designed by immunoinformatics tools was expressed in bacterial system. HEK-293T cells-derived exosomes were generated and characterized to use as a carrier for crocin and curcumin compounds. The exosomes loaded with crocin and curcumin compounds as a chemotherapeutic agent (ExoCrocin and ExoCurcumin) were used along with the L1-E7 polypeptide for evaluation of immunological and anti-tumor effects in C57BL/6 mouse model. In vitro studies showed that ExoCrocin and ExoCurcumin were not cytotoxic at a certain dose, and they could enter tumor cells. In vivo studies indicated that combination of the L1-E7 polypeptide with ExoCrocin or ExoCurcumin could produce a significant level of immunity directed toward Th1 response and CTL activity. These regimens showed the protective and therapeutic effects against tumor cells (the percentage of tumor-free mice: ~100%). In addition, both ExoCrocin and ExoCurcumin represented similar immunological and anti-tumor effects. Generally, the use of exosomal crocin or curcumin forms along with the L1-E7 polypeptide could significantly induce T-cell immune responses and eradicate tumor cells.

2021 ◽  
Vol 11 ◽  
Lijun Wang ◽  
Jing Li ◽  
Rongli Wang ◽  
He Chen ◽  
Ruiqi Wang ◽  

Nerve growth factor (NGF) is increasingly implicated in cervical cancer progression, but its mechanism in cervical cancer is unclear. Here, studies demonstrate that NGF inhibits the Hippo signaling pathway and activates Yes-associated protein (YAP) to induce cervical cancer cell proliferation and migration. Our results suggested that stimulation of NGF promoted cell growth and migration and activated YAP in HeLa and C-33A cell lines. The expression of YAP target genes (CTGF and ANKRD1) was upregulated after NGF treatment. The NGF inhibitor Ro 08-2750 and siRNA-mediated NGF receptor gene silencing suppressed HeLa and C-33A cells proliferation and migration, activated large suppressor kinase 1 (LATS1) kinase activity, and suppressed YAP function. In addition, the expression of YAP target genes (CTGF and ANKRD1) was suppressed by Ro 08-2750 treatment in HeLa and C-33A cells. Interestingly, proliferation was significantly higher in NGF-treated cells than in control cells, and this effect was completely reversed by the YAP small molecule inhibitor-verteporfin. Furthermore, the mouse xenograft model shows that NGF regulates YAP oncogenic activity in vivo. Mechanistically, NGF stimulation inactivates LATS1 and activates YAP, and NGF inhibition was found to induce large suppressor kinase 1 (LATS1) phosphorylation. Taken together, these data provide the first direct evidence of crosstalk between the NGF signaling and Hippo cancer pathways, an interaction that affects cervical cancer progression. Our study indicates that combined targeting of the NGF signaling and the Hippo pathway represents a novel therapeutic strategy for treatment of cervical cancer.

2021 ◽  
Vol 24 (6) ◽  
Lei Dou ◽  
Xinxin Zhang

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