Hepatic Impairment Physiologically Based Pharmacokinetic Model Development: Current Challenges

Current Pharmacology Reports ◽

10.1007/s40495-021-00266-5 ◽

2021 ◽

Author(s):

Agnes Nuo Han ◽

Beatrice Rae Han ◽

Tao Zhang ◽

Tycho Heimbach

Keyword(s):

Hepatic Impairment ◽

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

Download Full-text

Physiologically‐Based Pharmacokinetic Model for Alectinib, Ruxolitinib, and Panobinostat in The Presence of Cancer, Renal Impairment, and Hepatic Impairment

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2282 ◽

2021 ◽

Author(s):

Mo'tasem M. Alsmadi

Keyword(s):

Renal Impairment ◽

Hepatic Impairment ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

European Neuropsychopharmacology ◽

10.1016/s0924-977x(17)31940-5 ◽

2017 ◽

Vol 27 ◽

pp. S1120

Author(s):

P. Coppola ◽

F. Calisti ◽

R. Picollo ◽

A. Ke ◽

F. Garofolo ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

Download Full-text

Pediatric Physiologically Based Pharmacokinetic Model Development: Current Status and Challenges

Current Pharmacology Reports ◽

10.1007/s40495-018-0162-1 ◽

2018 ◽

Vol 4 (6) ◽

pp. 491-501

Author(s):

Wen Lin ◽

Jing-He Yan ◽

Tycho Heimbach ◽

Handan He

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Current Status ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

A Δ9-Tetrahydrocannabinol Physiologically-Based Pharmacokinetic Model Development in Humans

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-020-00617-5 ◽

2020 ◽

Vol 45 (4) ◽

pp. 495-511 ◽

Author(s):

Janthima Methaneethorn ◽

Chomkanang Poomsaidorn ◽

Kanyamas Naosang ◽

Parichart Kaewworasut ◽

Manupat Lohitnavy

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

A Physiologically Based Pharmacokinetic Model of Zidovudine (AZT) in the Mouse: Model Development and Scale-Up to Humans

Journal of Pharmaceutical Sciences ◽

10.1021/js970243y ◽

1997 ◽

Vol 86 (11) ◽

pp. 1223-1228 ◽

Author(s):

Hsiao-Hui Chow

Keyword(s):

Mouse Model ◽

Pharmacokinetic Model ◽

Scale Up ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2008.05.002 ◽

2008 ◽

Vol 51 (3) ◽

pp. 311-323 ◽

Author(s):

Lisa M. Sweeney ◽

Shakil A. Saghir ◽

Michael L. Gargas

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Ethylene Dichloride ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104667 ◽

2020 ◽

Vol 114 ◽

pp. 104667 ◽

Author(s):

Corie A. Ellison ◽

Shengde Wu

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Preliminary Physiologically Based Pharmacokinetic Model for Cocaine in the Rat: Model Development and Scale-Up to Humans

Journal of Pharmaceutical Sciences ◽

10.1021/js950437i ◽

1996 ◽

Vol 85 (8) ◽

pp. 878-883 ◽

Author(s):

Peter L. Bonatex ◽

Alan Swann ◽

Peter B. Silverman

Keyword(s):

Rat Model ◽

Pharmacokinetic Model ◽

Scale Up ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime

Environmental Research ◽

10.1016/j.envres.2021.111287 ◽

2021 ◽

pp. 111287

Author(s):

Deepika Deepika ◽

Raju Prasad Sharma ◽

Marta Schuhmacher ◽

Vikas Kumar

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Perfluorooctane Sulfonate ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Download Full-text