Effect of whole-body hypothermia on myocardial blood flow and infarct salvage during coronary artery occlusion in dogs

1984 ◽  
Vol 107 (5) ◽  
pp. 945-949 ◽  
Author(s):  
William D. Voorhees ◽  
Dana R. Abendschein ◽  
Willis A. Tacker
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Whole Body

Effect of hyperoxia on regional blood flow after coronary occlusion in awake dogs

1980 ◽  
Vol 238 (2) ◽  
pp. H244-H248 ◽  
Author(s):  
F. Rivas ◽  
J. C. Rembert ◽  
R. J. Bache ◽  
F. R. Cobb ◽  
J. C. Greenfield
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Regional Blood Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Regional Myocardial Blood Flow ◽  
Circumflex Coronary Artery ◽  
Left Circumflex Coronary Artery ◽  
Oxygen Inhalation

The effect of 100% oxygen inhalation on regional transmural myocardial blood flow following 45 s of actue total left circumflex coronary artery occlusion was studied in six awake dogs chronically instrumented with a coronary occluder and catheters in the aorta and left atrium. After inhalation of either room air or 100% oxygen for at least 30 min and following the 45-s occlusion, transmural myocardial blood flow was determined with radioactive microspheres (7--10 micrometers). Each dog underwent two occlusions of the left circumflex coronary artery; one during inhalation of rrom air and the other during 100% oxygen. During room air inhalation, mean regional myocardial blood flow to nonischemic, intermediate, and ischemic regions was 0.92 +/- 0.05, 0.51 +/- 0.08, and 0.10 +/- 0.02 ml . min-1 . g-1, respectively. During 100% oxygen administration, flow was significantly diminished in each region to 0.75 +/- 0.04, 0.41 +/- 0.07, and 0.06 +/- 0.01 ml . min-1 . g-1, respectively. Transmural blood flow to each layer was uniformly reduced in all regions. These data indicate that 100% oxygen further reduces myocardial blood flow to ischemic regions.

Effect of alpha 1-adrenergic blockade on myocardial blood flow during exercise after myocardial infarction

1991 ◽  
Vol 261 (2) ◽  
pp. H280-H286 ◽  
Author(s):  
C. A. Herzog ◽  
X. Z. Dai ◽  
R. J. Bache
Keyword(s):  
Myocardial Infarction ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Adrenergic Blockade ◽  
Flow Ratio ◽  
External Work ◽  
Comparable Rate

The effect of alpha 1-adrenergic blockade with prazosin on myocardial blood flow at rest and during two levels of treadmill exercise was assessed in 16 chronically instrumented dogs 9-14 days after myocardial infarction had been produced by occlusion of the left circumflex coronary artery. During resting conditions prazosin did not alter mean myocardial blood flow or the subendocardial-to-subepicardial flow ratio in either normally perfused or collateral-dependent myocardium. However, during exercise at comparable external work loads and comparable rate-pressure products, prazosin significantly increased blood flow to normally perfused (27% increase at the second level of exercise, P less than 0.001) and collateral-dependent myocardium (35% increase at the second level of exercise, P less than 0.001) compared with control. In addition, prazosin caused a small but significant decrease in the subendocardial-to-subepicardial flow ratio in both normal (1.27 +/- 0.04 to 1.19 +/- 0.04; P less than 0.01) and collateral-dependent myocardium (0.57 +/- 0.11 to 0.52 +/- 0.11; P less than 0.01) compared with control, reflecting a disproportionally greater increase in subepicardial flow in response to alpha 1-adrenergic blockade. These data demonstrate that alpha 1-adrenergic vasoconstriction inhibits coronary vasodilation during exercise, even in areas of collateral-dependent myocardium relatively early after coronary artery occlusion.

scholarly journals Changes in myocardial blood flow and S-T segment elevation following coronary artery occlusion in dogs.

1975 ◽  
Vol 36 (6) ◽  
pp. 697-705 ◽  
Author(s):  
H J Smith ◽  
B N Singh ◽  
R M Norris ◽  
M B John ◽  
P J Hurley
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion
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