Effects of prazosin and labetalol on blood pressure control and blood lipid levels in patients with mild-to-moderate essential hypertension

1989 ◽  
Vol 86 (1) ◽  
pp. 41-44 ◽  
Author(s):  
John P. Farry ◽  
Stephen J. Fischl ◽  
Michael J. Tighe ◽  
Mark J. Krell
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Control ◽  
Blood Lipid ◽  
Pressure Control ◽  
Moderate Essential Hypertension ◽  
Lipid Levels ◽  
Blood Lipid Levels

ABPM Comparison of the Anti-Hypertensive Profiles of Telmisartan and Enalapril in Patients with Mild-to-Moderate Essential Hypertension

2002 ◽  
Vol 30 (6) ◽  
pp. 543-552 ◽  
Author(s):  
J Amerena ◽  
S Pappas ◽  
J-P Ouellet ◽  
L Williams ◽  
D O'Shaughnessy
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Monitoring ◽  
Study Drug ◽  
Pressure Control ◽  
Moderate Essential Hypertension ◽  
Open Label ◽  
Night Time ◽  
Once Daily

In this multicentre, prospective, randomized, open-label, blinded-endpoint (PROBE) study, the efficacy of 12 weeks' treatment with once-daily telmisartan 40–80 mg and enalapril 10–20 mg was evaluated using ambulatory blood pressure monitoring (ABPM) in 522 patients with mild-to-moderate essential hypertension. Patients were titrated to the higher dose of study drug at week 6 if mean seated diastolic blood pressure (DBP) was ≥ 90 mmHg. The primary endpoint was the change from baseline in ambulatory DBP in the last 6 h of the 24-h dosing interval after 12 weeks' treatment. Telmisartan and enalapril produced similar reductions from baseline in DBP and systolic blood pressure (SBP) over all ABPM periods evaluated (last 6 h, 24-h, daytime and night-time). Telmisartan produced a significantly greater reduction in mean seated trough DBP, measured unblinded with an automated ABPM device in the clinic, amounting to a difference of −2.02 mmHg ( P < 0.01). A significantly greater proportion of patients achieved a seated diastolic response with telmisartan than enalapril (59% versus 50%; P < 0.05), also measured with the same ABPM device. Both treatments were well tolerated. Compared with telmisartan, enalapril was associated with a higher incidence of cough (8.9% versus 0.8%) and hypotension (3.9% versus 1.1%). Therefore, telmisartan may provide better long-term compliance and, consequently, better blood pressure control than enalapril.

Chronotherapy With Valsartan/Hydrochlorothiazide Combination in Essential Hypertension: Improved Sleep-Time Blood Pressure Control With Bedtime Dosing

2011 ◽  
Vol 28 (7) ◽  
pp. 601-610 ◽  
Author(s):  
Ramón C. Hermida ◽  
Diana E. Ayala ◽  
Artemio Mojón ◽  
María J. Fontao ◽  
José R. Fernández
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Sleep Time

Age and Race Determine Vasopressin Participation in Upright Blood Pressure Control in Essential Hypertension

1993 ◽  
Vol 689 (1 The Neurohypo) ◽  
pp. 534-536 ◽  
Author(s):  
ROGERIO B. PAULA ◽  
FRIDA L. PLAVNIK ◽  
CIBELE I. S. RODRIGUES ◽  
FRANCISCO A ROCHA NEVES ◽  
OSVALDO KOHLMANN ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Control ◽  
Pressure Control
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