Thermally controlled microfluidic back pressure regulator

By using the temperature dependence of viscosity, we introduce a novel type of microfluidic lab-on-a-chip back pressure regulator (BPR) that can be integrated into a micro-total-analysis-system. A BPR is an important component used to gain pressure control and maintain elevated pressures in e.g. chemical extractions, synthesis, and analyses. Such applications have been limited in microfluidics, since the back pressure regularly has been attained by passive restrictors or external large-scale BPRs. Herein, an active microfluidic BPR is presented, consisting of a glass chip with integrated thin-film heaters and thermal sensors. It has no moving parts but a fluid restrictor where the flow resistance is controlled by the change of viscosity with temperature. Performance was evaluated by regulating the upstream pressure of methanol or water using a PID controller. The developed BPR has the smallest reported dead volume of 3 nL and the thermal actuation has time constants of a few seconds. The pressure regulation were reproducible with a precision in the millibar range, limited by the pressure sensor. The time constant of the pressure changes was evaluated and its dependence of the total upstream volume and the compressibility of the liquids is introduced.

Primary Hyperaldosteronism: When to Suspect It and How to Confirm Its Diagnosis

The definition of primary hyperaldosteronism (PA) has shifted, as progress has been made in understanding the disease. PA can be produced by unilateral or bilateral cortical adrenal hyperproduction of aldosterone, due to hyperplasia, aldosterone-secreting cell clusters, aldosterone-producing macro or micro adenoma/s, and combinations of the above, or by an aldosterone-producing carcinoma. PA is a highly prevalent disease, affecting close to 10% of the hypertensive population. However, PA is clearly underdiagnosed. The purpose of this review is to address current knowledge of PA’s clinical manifestations, as well as current methods of diagnosis. PA is associated with a higher cardiovascular morbidity and mortality than essential hypertension with similar blood pressure control. Young hypertensive patients, those with a first-degree relative with PA or ictus, and/or those with apnea/hypopnea syndrome, moderate/severe/resistant hypertension, adrenal incidentaloma, and/or hypokalemia should be screened for PA. PA can induce atrial fibrillation (AF), and those patients should also be screened for PA. We propose the use of the Captopril challenge test (CCT), oral salt loading, or intravenous salt loading for PA diagnosis, given their availability in the majority of hospital centers. CCT could be first-line, since it is safe and easy to perform.

DESIGN IMPLEMENTATION ANDON FOR PRODUCTION MONITORING SYSTEM BASED ON INTERNET OF THINGS

Each production requires a system monitoring, so efficiency that the desired and productivity can be achieved and monitored in real time. This system is needed in the type of press machine production which is mainly influenced by based production lead time. The monitoring process is one of the factors that influences the time of production and manufacturing. Conventionally, the system is monitoring carried out manually by the operator on a piece of paper. This method tends to create errors and quite a long time. This paper aims to overcome the problems that occur by creating a system that is able to record and monitor the machine automatically. The solution is made by utilizing a sensor limit switch, infrared, pressure transmitter and Wi-Fi network based on Web Interface that is connected to the Firebase real time database. Equipped with PID control using the Ziegler Nichols 1 method to stabilize wind pressure on the system. Monitoring devices can be accessed on PCs, laptops, smartphones, connected to the internet, equipped with user-level operators, management, or engineers so that they can be used easily. All production data for each press is collected in a database. The data will be processed by the system to produce a value OEE machine. All data will be displayed on the Web Interface in real-time. The system output is the actual production, value OEE and wind pressure control. The test results show the system is running well, with 2s delay time and data accuracy of ± 0.2%.

Experimental Validation of a Hydrostatic Transmission for Community Wind Turbines

Hydrostatic transmissions are commonly used in heavy-duty equipment for their design flexibility and superior power density. Compared to a conventional wind turbine transmission, a hydrostatic transmission (HST) is a lighter, more reliable, cheaper, continuously variable alternative for a wind turbine. In this paper, for the first time, a validated dynamical model and controlled experiment have been used to analyze the performance of a hydrostatic transmission with a fixed-displacement pump and a variable-displacement motor for community wind turbines. From the dynamics of the HST, a pressure control strategy is designed to maximize the power capture. A hardware-in-the-loop simulation is developed to experimentally validate the performance and efficiency of the HST drive train control in a 60 kW virtual wind turbine environment. The HST turbine is extensively evaluated under steady and time-varying wind on a state-of-the-art power regenerative hydrostatic dynamometer. The proposed controller tracks the optimal tip-speed ratio to maximize power capture.

Management of hypertension and renin-angiotensin-aldosterone system blockade in adults with diabetic kidney disease: Association of British Clinical Diabetologists and the Renal Association UK guideline update 2021

People with type 1 and type 2 diabetes are at risk of developing progressive chronic kidney disease (CKD) and end-stage kidney failure. Hypertension is a major, reversible risk factor in people with diabetes for development of albuminuria, impaired kidney function, end-stage kidney disease and cardiovascular disease. Blood pressure control has been shown to be beneficial in people with diabetes in slowing progression of kidney disease and reducing cardiovascular events. However, randomised controlled trial evidence differs in type 1 and type 2 diabetes and different stages of CKD in terms of target blood pressure. Activation of the renin-angiotensin-aldosterone system (RAAS) is an important mechanism for the development and progression of CKD and cardiovascular disease. Randomised trials demonstrate that RAAS blockade is effective in preventing/ slowing progression of CKD and reducing cardiovascular events in people with type 1 and type 2 diabetes, albeit differently according to the stage of CKD. Emerging therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors, non-steroidal selective mineralocorticoid antagonists and endothelin-A receptor antagonists have been shown in randomised trials to lower blood pressure and further reduce the risk of progression of CKD and cardiovascular disease in people with type 2 diabetes. This guideline reviews the current evidence and makes recommendations about blood pressure control and the use of RAAS-blocking agents in different stages of CKD in people with both type 1 and type 2 diabetes.

Faktor-Faktor yang Mempengaruhi Pengontrolan Tekanan Darah pada Penderita Hipertendi di RW 03 Kelurahan Jagakarsa Jakarta Selatan

ABSTRACT: FACTORS AFFECTING BLOOD PRESSURE CONTROL IN HYPERTENSION PATIENTS IN RW 03 KELURAHAN JAGAKARSA SOUTH JAKARTA Introduction: Blood pressure control is controlling blood pressure with systolic <140 mmHg and diastolic <90 mmHg. Controlling blood pressure in people with hypertension can be done by losing weight, exercising, adjusting a low-salt diet, improving unhealthy lifestyles, and pharmacological therapy. Blood pressure control is influenced by several factors, such as attitudes, knowledge, family support, and medication adherence.Objective: The purpose of this study was to determine the factors that influence blood pressure control in hypertension sufferers in RW 03 Jagakarsa Village, South Jakarta.Methods: The research design used was descriptive-analytic with a cross sectional approach. The number of samples involved were 42 respondents using the Z formula. The results of the study used Chi-Square statistical test analysis.Results: The results of this study obtained factors related to controlling blood pressure in patients with hypertension, namely attitude (p-value = 0.047), knowledge (p-value = 0.040), family support (p-value = 0.025), and medication. compliance (p-value = 0.040).Conclusion: Suggestions from this study are health services, especially in the community, to find out the factors that influence blood pressure control in hypertension sufferers, one of which can be overcome by developing health education programs for the community, both at the puskesmas and at the posyandu. Thus, blood pressure control can be carried out optimally for a better life. Keywords: Hypertension, Blood Pressure Control, Attitude, Knowledge INTISARI: FAKTOR-FAKTOR YANG MEMPENGARUHI PENGONTROLAN TEKANAN DARAH PADA PENDERITA HIPERTENDI DI RW 03 KELURAHAN JAGAKARSA JAKARTA SELATAN Pendahuluan: Pengontrolan tekanan darah merupakan tekanan darah yang terkontrol dengan sistole <140 mmHg dan diastole <90 mmHg. pengontrolan tekanan darah pada penderita hipertensi dapat dilakukan dengan cara penurunan berat badan, olahraga, pengaturan diet rendah garam, memperbaiki gaya hidup yang kurang sehat, dan terapi farmakologis. Pengontrolan tekanan darah dipengaruhi oleh beberapa faktor, seperti sikap, pengetahuan, dukungan keluarga dan kepatuhan pengobatan.Tujuan: Tujuan penelitian ini adalah untuk Mengetahui faktor-faktor yang mempengaruhi pengontrolan tekanan darah pada penderita hipertensi di RW 03 Kelurahan Jagakarsa Jakarta Selatan.Metode: Desain penelitian yang digunakan adalah deskriptif-analitik dengan pendekatan cross-sectional. Jumlah sampel yang dilibatkan sebanyak 42 responden dengan menggunakan rumus Z. Hasil penelitian menggunakan analisis uji statistic Chi-Square.Hasil: Hasil dari penelitian ini diperoleh faktor yang berhubungan dengan pengontrolan tekanan darah pada penderita hipertensi yaitu sikap (p-value = 0,047), pengetahuan (p-value = 0,040), dukungan keluarga (p-value = 0,025), dan kepatuhan pengobatan (p-value = 0,040).Kesimpulan: Saran dari penelitian ini adalah pelayanan kesehatan khususnya di masyarakat untuk mengetahui bahwa faktor-faktor yang mempengaruhi pengontrolan tekanan darah pada penderita hipertensi dapat diatasi salah satunya dengan mengembangkan program penyuluhan kesehatan bagi masyarakat baik di internal puskesmas maupun dilakukan di posyandu. Sehingga, pengontrolan tekanan darah dapat dilakukan secara optimal untuk menjalankan hidup yang lebih baik. Kata Kunci : Hipertensi, Pengontrolan Tekanan Darah, Sikap, Pengetahuan