In cooperation with the Association for the Advancement of Artificial Intelligence (AAAI), the Twenty-Second International Conference on Case-Based Reasoning (ICCBR), the premier international meeting on research and applications in case-based reasoning (CBR), was held from Monday September 29 to Wednesday October 1, 2014, in Cork, Ireland. ICCBR is the annual meeting of the CBR community and the leading conference on this topic. Started in 1993 as the European Conference on CBR and 1995 as ICCBR, the two conferences alternated biennially until their merger in 2010.