Amastatin interferes with the antagonist properties of MEN 10,208 in the rabbit pulmonary artery but not in the hamster trachea

1993 ◽  
Vol 236 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Riccardo Patacchini ◽  
Carlo Alberto Maggi
Keyword(s):  
Pulmonary Artery ◽  
Rabbit Pulmonary Artery ◽  
Hamster Trachea

Responses of isolated pulmonary arteries to synthetic peptide F-Met-Leu-Phe

1989 ◽  
Vol 257 (1) ◽  
pp. H107-H112
Author(s):  
R. E. Crowell ◽  
D. E. Van Epps ◽  
W. P. Reed
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Receptor Antagonist ◽  
Synthetic Peptide ◽  
Pulmonary Arteries ◽  
Histamine Receptor ◽  
Relaxation Response ◽  
Rabbit Pulmonary Artery ◽  
Resting Tension ◽  
Thromboxane Synthetase

The chemoattractant formyl-methionine-leucine-phenylalanine (FMLP) has recently been shown to possess spasmogenic properties in smooth muscle preparations from various organs. In this study we have investigated the actions of this peptide on isolated rabbit pulmonary artery (PA) ring segments. FMLP stimulated concentration-dependent constriction of PA at resting tension. However, in PA that had been preconstricted by norepinephrine, FMLP stimulated concentration-dependent relaxation. FMLP-stimulated PA constriction was inhibited by earlier exposure to indomethacin or to furegrelate, a thromboxane synthetase inhibitor, but not by earlier exposure to the H1 histamine receptor antagonist pyrilamine. FMLP-stimulated relaxation of PA was totally abolished by indomethacin but not by furegrelate or pyrilamine. Disruption of the endothelium in PA preparations decreased both the constriction and relaxation response to the peptide, suggesting that these cells were involved in these responses. These results indicate that the chemotactic factor FMLP can elicit constriction or relaxation of isolated PA, depending on the underlying active PA tension. In addition, both constriction and relaxation are dependent on cyclooxygenase products and intact endothelium.

High potassium-evoked release of ATP from rabbit pulmonary artery via endogenous noradrenaline

1995 ◽  
Vol 26 (6) ◽  
pp. 1385-1390 ◽  
Author(s):  
Koichi Takeuchi ◽  
Reiko Ishii ◽  
Kazumasa Shinozuka ◽  
Takao Hashimoto
Keyword(s):  
Pulmonary Artery ◽  
High Potassium ◽  
Rabbit Pulmonary Artery ◽  
Endogenous Noradrenaline

Endothelin-1-induced potentiation of adrenergic responses in the rabbit pulmonary artery: role of thromboxane A2

2001 ◽  
Vol 413 (2-3) ◽  
pp. 247-254 ◽  
Author(s):  
José M. Vila ◽  
Pascual Medina ◽  
Gloria Segarra ◽  
Martı́n Aldasoro ◽  
Inmaculada Noguera ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Thromboxane A2 ◽  
Rabbit Pulmonary Artery ◽  
Endothelin 1

Characterization of the tachykinin NK2 receptor subtype in the rabbit pulmonary artery

Peptides ◽  
1992 ◽  
Vol 13 (2) ◽  
pp. 281-285 ◽  
Author(s):  
Xiao-Hui Xiao ◽  
Christian J. Mussap ◽  
Elizabeth Burcher
Keyword(s):  
Pulmonary Artery ◽  
Receptor Subtype ◽  
Rabbit Pulmonary Artery ◽  
Nk2 Receptor ◽  
Tachykinin Nk2 Receptor
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