In vivo quantification of dopamine D2 receptor parameters in nonhuman primates with [123I]iodobenzofuran and single photon emission computerized tomography

1994 ◽  
Vol 263 (1-2) ◽  
pp. 39-51 ◽  
Author(s):  
Marc Laruelle ◽  
Mohammed S Al-Tikriti ◽  
Yolanda Zea-Ponce ◽  
Sami S Zoghbi ◽  
Ronald M Baldwin ◽  
...  
Keyword(s):  
Computerized Tomography ◽  
Nonhuman Primates ◽  
Single Photon ◽  
Dopamine D2 Receptor ◽  
Photon Emission ◽  
D2 Receptor ◽  
Single Photon Emission ◽  
Dopamine D2

Dopamine D2 Receptor Blockade and Antimigraine Action of Flunarizine

Cephalalgia ◽  
1994 ◽  
Vol 14 (3) ◽  
pp. 235-240 ◽  
Author(s):  
C Wöber ◽  
T Brücke ◽  
C Wöber-Bingöl ◽  
S Asenbaum ◽  
P Wessely ◽  
...  
Keyword(s):  
Single Photon ◽  
Dopamine D2 Receptor ◽  
Photon Emission ◽  
D2 Receptor ◽  
High Specificity ◽  
D2 Receptors ◽  
Binding Potential ◽  
Receptor Blockade ◽  
Dopamine D2

We studied in vivo the influence of flunarizine on dopamine D2 receptors and investigated whether dopamine D2 receptor blockade is involved in its antimigraine action. Eleven migraine patients, treated with flunarizine, 10 mg per day, underwent single photon emission computer tomography (SPECT) using [123I] labeled iodobenzamide, a ligand with high affinity and high specificity for D2 receptors. There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls. The efficacy of flunarizine in migraine prophylaxis failed to correlate with the degree of the dopamine D2 receptor blockade. The antimigraine action of flunarizine may not involve antidopaminergic mechanisms.

In Vivo Quantitative Noninvasive Imaging of Gene Transfer by Single-Photon Emission Computerized Tomography

2003 ◽  
Vol 14 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Alberto Auricchio ◽  
Paul D. Acton ◽  
Markus Hildinger ◽  
Jean-Pierre Louboutin ◽  
Karl Plössl ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Computerized Tomography ◽  
Single Photon ◽  
Noninvasive Imaging ◽  
Photon Emission ◽  
Single Photon Emission

scholarly journals Diagnostic imaging of dopamine receptors in pituitary adenomas

2007 ◽  
Vol 156 (suppl_1) ◽  
pp. S53-S56 ◽  
Author(s):  
Wouter W de Herder ◽  
Ambroos E M Reijs ◽  
Richard A Feelders ◽  
Maarten O van Aken ◽  
Eric P Krenning ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Single Photon ◽  
Dopamine D2 Receptor ◽  
Photon Emission ◽  
D2 Receptor ◽  
Pituitary Tumour ◽  
D2 Receptors ◽  
Emission Computed Tomography ◽  
Dopamine D2 ◽  
Pituitary Macroadenomas

Dopamine D2 receptor scintigraphy of pituitary adenomas is feasible by single-photon emission computed tomography using 123I-S-(−)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-iodo-6-methoxybenzamide (123I-IBZM) and 123I-epidepride. 123I-epidepride is generally superior to 123I-IBZM for the visualization of D2 receptors on pituitary macroadenomas. However, 123I-IBZM and 123I-epidepride scintigraphy are generally not useful to predict the response to dopaminergic treatment in pituitary tumour patients. These techniques might allow discrimination of non-functioning pituitary macroadenomas from other non-tumour pathologies in the sellar region. Dopamine D2 receptors on pituitary tumours can also be studied using positron emission tomography with 11C-N-raclopride and 11C-N-methylspiperone.

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