Involvement of the myenteric plexus in the cholera toxin-induced net fluid secretion in the rat small intestine

1993 ◽  
Vol 105 (5) ◽  
pp. 1286-1293 ◽  
Author(s):  
Mats Jodal ◽  
Susanne Holmgren ◽  
Ove Lundgren ◽  
Anders Sjöqvist
Keyword(s):  
Small Intestine ◽  
Cholera Toxin ◽  
Myenteric Plexus ◽  
Fluid Secretion ◽  
Rat Small Intestine

Effect of Bicarbonate, Acetate, and Citrate on Water and Sodium Movement in Normal and Cholera Toxin-Treated Rat Small Intestine

1989 ◽  
Vol 24 (1) ◽  
pp. 1-8 ◽  
Author(s):  
D. D. K. Rolston ◽  
M. J. Kelly ◽  
M. M. Borodo ◽  
A. M. Dawson ◽  
M. J. G. Farthing
Keyword(s):  
Small Intestine ◽  
Cholera Toxin ◽  
Rat Small Intestine

scholarly journals Cholera toxin effects on fluid secretion, adenylate cyclase, and cyclic AMP in porcine small intestine.

1978 ◽  
Vol 21 (2) ◽  
pp. 373-380 ◽  
Author(s):  
G W Forsyth ◽  
D L Hamilton ◽  
K E Goertz ◽  
M R Johnson
Keyword(s):  
Small Intestine ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Cholera Toxin ◽  
Fluid Secretion

Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine

1996 ◽  
Vol 270 (6) ◽  
pp. G1001-G1009 ◽  
Author(s):  
B. A. Moore ◽  
K. A. Sharkey ◽  
M. Mantle
Keyword(s):  
Small Intestine ◽  
Receptor Antagonist ◽  
Cholera Toxin ◽  
Receptor Subtypes ◽  
Rat Small Intestine ◽  
Mucin Secretion ◽  
Common Pathway ◽  
Distal Small Intestine ◽  
Intestinal Segments

We examined the role of 5-hydroxytryptamine (5-HT) in cholera toxin (CT)-induced mucin secretion in the proximal and distal regions of the rat small intestine. Neither the 5-HT2 receptor antagonist ketanserin nor the cyclooxygenase inhibitor indomethacin was capable of inhibiting choleraic mucin secretion. However, in the presence of the mixed 5-HT3/4 receptor antagonist tropisetron at doses that block both receptor subtypes, the secretory response was reduced to baseline levels in the proximal and distal small intestine. The selective 5-HT3 receptor antagonist ondansetron had no significant effect. These findings suggest that choleraic mucin secretion is mediated primarily through the activation of a 5-HT4-like receptor. Mucin secretion in response to the exogenous application of 5-HT occurs via two pathways: one is mediated by a 5-HT4-like receptor and is capsaicin sensitive but tetrodotoxin (TTX) insensitive, and one lacks the capsaicin-sensitive 5-HT4-mediated response but is TTX sensitive. Both converge on a common pathway that is cholinergic. No significant differences were observed between proximal and distal intestinal segments.

scholarly journals Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine.

Gut ◽  
1996 ◽  
Vol 38 (6) ◽  
pp. 853-858 ◽  
Author(s):  
I R Sanderson ◽  
Z Xu ◽  
S W Chu ◽  
Q Y Xie ◽  
L J Levine ◽  
...  
Keyword(s):  
Small Intestine ◽  
Adenylate Cyclase ◽  
Cholera Toxin ◽  
Developmental Differences ◽  
Rat Small Intestine ◽  
Gs Alpha
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