Acetorphan inhibits cholera toxin-induced water and electrolyte secretion in the human jejunum

1995 ◽  
Vol 108 (4) ◽  
pp. A668
Keyword(s):  
Cholera Toxin ◽  
Electrolyte Secretion ◽  
Water And Electrolyte Secretion

Acetorphan prevents cholera-toxin-induced water and electrolyte secretion in the human jejunum

1997 ◽  
Vol 9 (9) ◽  
pp. 887-891 ◽  
Author(s):  
Thomas A. Hinterleitner ◽  
Wolfgang Petritsch ◽  
Gudrun Dimsity ◽  
Hugues Berard ◽  
J.-M. Lecomte ◽  
...  
Keyword(s):  
Cholera Toxin ◽  
Electrolyte Secretion ◽  
Water And Electrolyte Secretion

scholarly journals Prostaglandin E2 is a mediator of 5-hydroxytryptamine induced water and electrolyte secretion in the human jejunum.

Gut ◽  
1988 ◽  
Vol 29 (10) ◽  
pp. 1337-1341 ◽  
Author(s):  
L K Munck ◽  
A Mertz-Nielsen ◽  
H Westh ◽  
K Bukhave ◽  
E Beubler ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Electrolyte Secretion ◽  
Water And Electrolyte Secretion

Reversal of cholera toxin-induced secretion in rat ileum by luminal berberine

1981 ◽  
Vol 241 (3) ◽  
pp. G248-G252 ◽  
Author(s):  
E. A. Swabb ◽  
Y. H. Tai ◽  
L. Jordan
Keyword(s):  
Polyethylene Glycol ◽  
Cholera Toxin ◽  
Electrolyte Transport ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Berberine Hydrochloride ◽  
Rat Ileum ◽  
Normal Water ◽  
Electrolyte Secretion

The effect of luminal berberine hydrochloride concentration on cholera toxin-induced water and electrolyte secretion and on normal water and electrolyte transport was determined in vivo in the cannulated, perfused rat ileum using [14C]polyethylene glycol as a nonabsorbable marker. Berberine reduced the cholera toxin-induced secretion of water, Na, Cl, and calculated residual ion (primarily HCO3) in a concentration-dependent manner. The effect of berberine on cholera toxin-induced ileal secretion was evident 60-80 min after exposure and was reversed 60–80 min after removal of berberine from the perfusate. Mild changes in mucosal histology (villous tip edema) due to cholera toxin were also reversed by berberine. Berberine did not significantly alter normal ileal water and electrolyte transport.

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