Humoral and cellular responses to homologous extracts of Nematospiroides dubius and Nippostrongylus brasiliensis

1986 ◽  
Vol 16 (6) ◽  
pp. 601-606 ◽  
Author(s):  
Patricia Price ◽  
Keven J. Turner
Keyword(s):  
Cellular Responses ◽  
Nippostrongylus Brasiliensis ◽  
Nematospiroides Dubius

The relevance of in vitro anthelmintic screening tests employing the free-living stages of trichostrongylid nematodes

1984 ◽  
Vol 58 (2) ◽  
pp. 107-112 ◽  
Author(s):  
O.F. Ibarra ◽  
D.C. Jenkings
Keyword(s):  
Broad Spectrum ◽  
Haemonchus Contortus ◽  
Screening Tests ◽  
Nippostrongylus Brasiliensis ◽  
Good Activity ◽  
Free Living ◽  
Ostertagia Ostertagi ◽  
Nematospiroides Dubius ◽  
Antiparasitic Agents

AbstractThe response of the free-living stages of Nippostrongylus brasiliensis, Nematospiroides dubius, Haemonchus contortus, Trichostrongylus colubriformis and Ostertagia ostertagi to a wide variety of antiparasitic agents in vitro was investigated.All the major broad spectrum veterinary anthelmintics showed good activity against each of these worms with EC30 values varying from about 00002mg/1 for certain benzimidazoles and ivermectin to about 6–5 mg/1 for febantel. Of 22 known narrow spectrum anthelmintics useful only against H. contortus and/or helminths other than trichostrongyles, only 10% showed good activity at concentrations equal to or less than 100mg/1. Further, only one of 15 antiprotozoal agents showed good activity in these tests at the 100mg/1 level.

The influence of Nematospiroides dubius on subsequent Nippostrongylus brasiliensis infections in mice

Parasitology ◽  
1975 ◽  
Vol 71 (2) ◽  
pp. 349-355 ◽  
Author(s):  
D. Conwil Jenkins
Keyword(s):  
Larval Stage ◽  
Nippostrongylus Brasiliensis ◽  
The Face ◽  
Nematospiroides Dubius

The fecundity and longevity of Nippostrongylus brasiliensis was prolonged in mice previously infected with Nematospiroides dubius only when the former developed from the larval stage in those mice. Such worms appeared to be less immunogenic than worms which developed in mice never exposed to N. dubius.It is proposed that prolonged fecundity and longevity resulted from an adaptation undertaken by the worms in the face of host antibodies which had been developed against the pre-existing N. dubius infection.

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